Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy

Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy

1st Edition - June 26, 2017

Write a review

  • Editor: Raouf Khalil
  • Hardcover ISBN: 9780128127766
  • eBook ISBN: 9780128128312

Purchase options

Purchase options
Available
DRM-free (Mobi, PDF, EPub)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy, Volume, Volume 148, the latest volume in the Progress in Molecular Biology and Translational Science series covers a variety of timely topics, with chapters focusing on The Role of Matrix Metalloproteinases in Development, Repair, and Destruction of the Lungs, Matrix Metalloproteinases in Kidney Disease: Role in Pathogenesis and Potential as a Therapeutic Target, Regulation of Matrix Metalloproteinase in the Pathogenesis of Diabetic Retinopathy, Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia, and Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology. This volume is the second part of a thematic on matrix metalloproteinases and tissue remodeling in health and disease. It focuses on the role of MMPs in other systems, target tissues, and pathological disorders and the potential benefits of MMP inhibitors in various disorders.

Key Features

  • Serves as the second part of a thematic on matrix metalloproteinases and tissue remodeling in health and disease
  • Focuses on cardiovascular remodeling
  • Contains contributions from leading authorities on the topics
  • Publishes cutting-edge reviews in molecular biology

Readership

Undergraduate and graduate students, postgraduate trainees as well as established scientists, physicians and medical professionals with interest in the field of matrix metalloproteinases and tissue remodeling.

Table of Contents

  • 1. The Role of Matrix Metalloproteinases in Development, Repair, and Destruction of the Lungs
    Amanda Y. Hendrix and Farrah Kheradmand
    2. Matrix Metalloproteinases in Kidney Disease: Role in Pathogenesis and Potential as a Therapeutic Target
    Alan R. Parrish
    3. Regulation of Matrix Metalloproteinase in the Pathogenesis of Diabetic Retinopathy
    Renu A. Kowluru and Manish Mishra
    4. Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia
    Juanjuan Chen and Raouf A. Khalil
    5. Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology
    Ciro De Luca and Michele Papa
    6. Matrix Metalloproteinases in Bone Resorption, Remodeling, and Repair
    Katiucia B.S. Paiva and José M. Granjeiro
    7. Matrix Metalloproteinases and Synovial Joint Pathology
    Charles J. Malemud
    9. Metalloproteinases in Rheumatoid Arthritis: Potential Therapeutic Targets to Improve Current Therapies
    Yoshifumi Itoh
    9. The Roles of Matrix Metalloproteinases in Pancreatic Cancer
    Anna M. Knapinska, Christie-Anne Estrada and Gregg B. Fields
    10. Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders
    Jie Liu and Raouf A. Khalil

Product details

  • No. of pages: 446
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: June 26, 2017
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128127766
  • eBook ISBN: 9780128128312

About the Serial Volume Editor

Raouf Khalil

Raouf Khalil
Dr. Raouf Khalil is an MD PhD who is very interested in scientific research. After receiving his MD, he joined the graduate school and received his PhD in Pharmacology from the University of Miami, Florida. After doing postdoctoral training at Harvard University, he joined the faculty at University of Mississippi Medical Center. He then moved back to Harvard where he is now Associate Professor at Harvard Medical School and the Brigham and Women's Hospital, Boston, Massachusetts, USA. Dr. Khalil has long been interested in vascular physiology and cell biology. The main focus of his research laboratory is to study the cellular mechanisms of vascular tone under physiological conditions and the changes in these mechanisms in pathological conditions such as coronary artery disease, salt-sensitive hypertension, hypertension in pregnancy, preeclampsia, pulmonary hypertension, and chronic venous disease. State-of-the-art equipment to study various aspects of the vascular system at the whole animal, tissue, cellular, and molecular level are available in his laboratory. Powerful techniques such as physiological bioassays, radioimmunoassays, mRNA and protein analysis, cell and organ culture, immunofluorescence, digital imaging and confocal microscopy are also available. Dr. Khalil's research projects include investigation of endothelium-dependent mechanisms of vascular relaxation, calcium-dependent and calcium-independent mechanisms of vascular and uterine contraction, role of protein kinases and phosphatases in vascular and uterine smooth muscle contraction, mechanisms of sex differences in vascular tone, the role of endothelin in salt-sensitive hypertension, and the role of matrix metalloproteinases in hypertension in pregnancy, preeclampsia, pulmonary hypertension, and chronic venous disease.

Affiliations and Expertise

Division of Vascular Surgery, Brigham and Women's Hospital, Boston, MA, USA

Ratings and Reviews

Write a review

There are currently no reviews for "Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy"