Management of Periprosthetic Joint Infections (PJIs)
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Management of Periprosthetic Joint Infections (PJIs)

1st Edition - October 25, 2016

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  • Editors: J.J. Chris Arts, Jan Geurts
  • Hardcover ISBN: 9780081002056
  • eBook ISBN: 9780081002421

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Description

Management of Periprosthetic Joint Infections (PJIs): Management of PJIs discusses periprosthetic joint infection (PJI), a fairly rare occurrence that is nonetheless one of the most serious complications in joint replacement surgery. Intricate interactions between the pathogen, the host, and the implant can result in PJIs which are not only physically devastating for the patient, but also financially crippling for health authorities and insurance companies. Actions taken to minimize the risk of PJIs can be extremely challenging for the orthopaedic community. Consequently, new research, which is detailed in this comprehensive book, is being undertaken to minimize and manage these challenging infections.

Key Features

  • Provides essential background knowledge on the mechanisms and identification of PJIs
  • Dedicated chapters focus on the complex, but vital eccentricities between PJIs in different areas of the body
  • Contains contributions from a mixture of clinical and academic experts in the field, thus ensuring balanced coverage

Readership

Clinicians involved in the treatment of PJIs, Biomaterials scientists in academia and industry with an interest in anti-bacterial materials, Orthopaedic surgeons, Pathologists

Table of Contents

    • List of contributors
    • Preface
    • Part One: Fundamentals of periprosthetic joint infections
      • 1: Prevention of joint infections
        • Abstract
        • 1.1 Introduction
        • 1.2 Preoperative considerations
        • 1.3 Prevention of infection in the perioperative period
        • 1.4 Prevention of infection after arthroplasty
        • 1.5 Conclusions and future trends
      • 2: Biofilm formation and the biological response
        • Abstract
        • 2.1 Introduction
        • 2.2 Biofilm formation
        • 2.3 Resistance to antimicrobial agents
        • 2.4 Host response against biofilm
        • 2.5 Clinical significance of biofilm
        • 2.6 Therapeutic strategies against biofilm
        • 2.7 Future trends
      • 3: Biomaterials in treatment of orthopedic infections
        • Abstract
        • 3.1 Orthopedic implant-related infections
        • 3.2 Biomaterials
        • 3.3 Latest clinical evidence treatment osteomyelitis
        • 3.4 Summary
      • 4: S53P4 bioactive glass
        • Abstract
        • 4.1 Introduction
        • 4.2 Working mechanism
        • 4.3 Antibacterial effects
        • 4.4 Effect on angiogenesis
        • 4.5 Current clinical applications
      • 5: Experimental models in orthopedic infection research
        • Abstract
        • 5.1 Osteomyelitis
        • 5.2 Prostheses, osteosynthesis, and infection
        • 5.3 Treatment
        • 5.4 Infection development and prevention
        • 5.5 Experimental models for orthopedic infections
        • 5.6 Scoring of orthopedic infections in experimental models—(semi) systemic parameters
        • 5.7 Scoring of orthopedic infections in experimental models—imaging and histology
        • 5.8 Concluding remarks
    • Part Two: Types of periprosthetic joint infections
      • 6: Periprosthetic infection in the hip joint
        • Abstract
        • 6.1 Introduction
        • 6.2 Definition
        • 6.3 Classification
        • 6.4 Causative organisms
        • 6.5 Diagnosis
        • 6.6 Other new diagnostic tools
        • 6.7 Management
        • 6.8 Management of periprosthetic fracture in the presence of chronic PJI
        • 6.9 The eradication of biofilm: Goals for the future
        • 6.10 Conclusion
      • 7: Infection in total knee arthroplasty
        • Abstract
        • 7.1 Total knee arthroplasty today
        • 7.2 Infection risks and prevention
        • 7.3 Diagnosis
        • 7.4 Chronic TKA infection
        • 7.5 Management of the infected TKA
        • 7.6 One-stage revision
        • 7.7 Two-stage revision
        • 7.8 Outcomes
        • 7.9 Knee arthrodesis
        • 7.10 Complications
      • 8: Periprosthetic infection in shoulder and elbow joints
        • Abstract
        • 8.1 Introduction
        • 8.2 Clinical presentation
        • 8.3 Diagnostic testing
        • 8.4 Treatment and outcomes—Shoulder
        • 8.5 Treatment and outcomes—Elbow
        • 8.6 Conclusion and future directions
    • Part Three: Managing and treating periprosthetic joint infections
      • 9: Practice and guidelines for treating periprosthetic joint infections: Single- and two-stage revision
        • Abstract
        • 9.1 Introduction
        • 9.2 Patient preparation, implant removal, and surgical debridement
        • 9.3 Analysis of results
        • 9.4 Conclusions and future trends
      • 10: PMMA beads and spacers for local antibiotic administration
        • Abstract
        • 10.1 History
        • 10.2 Rationale and pharmacokinetics of antibiotic-loaded PMMA
        • 10.3 Beads
        • 10.4 Spacers
      • 11: Pathogen-directed antibiotic therapy
        • Abstract
        • 11.1 Introduction
        • 11.2 Cultures and diagnosis
        • 11.3 Prophylaxis and empirical therapy
        • 11.4 The pathogens in PJI
        • 11.5 The antibiotics
        • 11.6 Pathogen-directed choice
        • 11.7 Conclusion and areas for further research
    • Part Four: Case studies
      • 12: Imaging of prosthetic joint infections
        • Abstract
        • 12.1 Introduction
        • 12.2 Conventional imaging
        • 12.3 Nuclear imaging
        • 12.4 Imaging in the assessment of PJI
    • Index

Product details

  • No. of pages: 304
  • Language: English
  • Copyright: © Woodhead Publishing 2016
  • Published: October 25, 2016
  • Imprint: Woodhead Publishing
  • Hardcover ISBN: 9780081002056
  • eBook ISBN: 9780081002421

About the Editors

J.J. Chris Arts

Dr. J.J. Chris Arts is Associate Professor Translational Biomaterials Research Maastricht University Medical Center, the Netherlands and Lecturer and Scientist at Eindhoven University of Technology, the Netherlands. He is also Cofounder of European Society of Tissue Regeneration in Orthopaedics and Trauma, board member of Dutch Society for Biomaterials and Tissue Engineering, Dutch orthopedic Society Biotechnology workgroup and a reviewer for several orthopedic and biomaterials orientated peer-review journals.

Affiliations and Expertise

Maastricht University, Eindhoven University and Twente University, The Netherlands

Jan Geurts

Dr. J. A. P. Geurts is an Attending Orthopedic Surgeon, Adult Reconstruction Hip and Infection Unit, Maastricht University Medical Center, the Netherlands. He is also a Board Member of the Dutch Orthopaedic Society, Infection workgroup and a Reviewer for the Dutch Journal of Orthopaedics.

Affiliations and Expertise

Maastricht University Medical Center, The Netherlands

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