Malaria

Malaria

Immunology and Immunization

1st Edition - January 28, 1980

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  • Editor: Julius P. Kreier
  • eBook ISBN: 9781483257471

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Description

Malaria: Volume 3, Immunology and Immunization is a collection of papers dealing with malaria parasites, the methods for measuring the immunological response to plasmodia, and the vertebrates host's immune response to plasmodia. Some papers discuss immunization against sporozoites, against the exoerythrocytic stages of malaria parasites, against asexual blood-inhabiting stages of plasmodia, as well as gamete immunization in malaria. One paper describes various separation methods to isolate malaria parasites and their constituents. Another paper discusses in detail the theory and practice of methods used in measuring antibody responses which occur during plasmodial infections, including the antibody response against sporozoites, exoerythrocytic forms, and in the different blood stages. Another paper explains the vertebrate host's immune response to plasmodial infection as a homeostatic physiological response changing along with the progression of the disease. The changes in the dynamic cellular cascade are different as the disease progresses causing death, than when these lead to recovery. Another paper enumerates the parameters which determine malarial infectiousness from one individual to another such as the time of onset, duration, intensity of the blood infections, as well as the maturity, longevity, and rate of production of gametocytes. Pharmacologists, general medical practitioners, investigators, and laboratory technicians involved in malarial research will find the collection very useful.

Table of Contents


  • List of Contributors

    Preface

    Contents of Volumes 1 and 2

    Contents of Babesiosis

    1 The Isolation of Malaria Parasites and Their Constituents

    I. Introduction

    II. Isolation of Plasmodia and Their Constituents

    III. Conclusions

    References

    2 Methods for Measuring the Immunological Response to Plasmodia

    I. Introduction

    II. The Antibody Response against Sporozoites

    III. The Antibody Response against Exoerythrocytic Forms

    IV. The Antibody Response to Blood Stages

    Reference

    3 The Vertebrate Host’s Immune Response to Plasmodia

    I. Introduction

    II. The Immune Response against Plasmodia

    III. Summary and Hypothesis: Probable Mechanisms of Immunity to Plasmodia

    References

    4 Immunization against Sporozoites

    I. Introduction

    II. Immunization of Rodents against Sporozoite-Induced Malaria

    III. Immunization of Simian Hosts against Sporozoite-Induced Malaria

    IV. Immunization of Humans against Sporozoite-Induced Malaria

    V. Conclusions

    VI. Perspectives

    References

    5 Immunization against Exoerythrocytic Stages of Malaria Parasites

    I. Introduction

    II. Immune Responsiveness to Exoerythrocytic Stages

    III. Discussion

    References

    6 Immunization against Asexual Blood-Inhabiting Stages of Plasmodia

    I. Introduction

    II. Immunization against Bird Malaria Parasites

    III. Immunization against Rodent Malaria Parasites

    IV. Immunization against Simian Malaria Parasites

    V. Immunization against Human Malaria Parasites

    VI. Summary and Conclusion

    References

    7 Infectiousness and Gamete Immunization in Malaria

    I. Introduction

    II. Avian Malaria (Plasmodium gallinaceum)

    III. Rodent Malaria(Plasmodium yoelii)

    IV. Simian Malaria

    V. Human Malaria

    VI. Conclusions

    References

    Appendix 1 Prospects for Development of Vaccines against Plasmodium falciparum Infection

    I. Introduction

    II. Experimental Immunization against Plasmodium falciparum Blood Stages

    III. Immunization of Humans against Sporozoite-Induced Malaria

    IV. Prerequisites for Vaccines for Human Use

    V. Conclusions

    References

    Appendix 2 The Role of Vaccination in the Strategy of Malaria Control

    Text

    References

    Appendix 3 Prospects for Malaria Blood Stage Vaccine

    Text

    References

    Appendix 4 Manufacturing Aspects of Antiplasmodial Vaccine Production

    Text

    References

    Appendix 5 The Agency of International Development Program for Malaria Vaccine Research and Development

    Text

    Appendix 6 The Great Neglected Diseases of Mankind

    Text

    References

    Index

Product details

  • No. of pages: 364
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 28, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9781483257471

About the Editor

Julius P. Kreier

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