Description

Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications is the first comprehensive book for non-physicists that addresses the emerging and exciting technique of magnetic resonance spectroscopy. Divided into three sections, this book provides coverage of the key areas of concern for researchers. The first, on how MRS is acquired, provides a comprehensive overview of the techniques, analysis, and pitfalls encountered in MRS; the second, on what can be seen by MRS, provides essential background physiology and biochemistry on the major metabolites studied; the final sections, on why MRS is used, constitutes a detailed guide to the major clinical and scientific uses of MRS, the current state of teh art, and recent innovations.

Magnetic Resonance Spectroscopy will become the essential guide for people new to the technique and give those more familiar with MRS a new perspective.

Key Features

  • Chapters written by world-leading experts in the field
  • Fully illustrated
  • Covers both proton and non-proton MRS
  • Includes the background to novel MRS imaging approaches

Readership

Neuroscience researchers and clinicians (neurologists, radiologists, psychiatrists) using MR imaging

Table of Contents

Acknowledgements

Contributors

Introduction

Section 1: How MRS is Acquired

Section 2: Biochemistry—What Underlies the Signal?

Section 3: Applications of Proton MRS

Section 4: Applications of Non-Proton MRS

References

Section 1: Technical Aspects—How MRS is Acquired

Chapter 1.1. Basis of Magnetic Resonance

Introduction

MRS Methods

Conclusions

References

Chapter 1.2. Localized Single-Voxel Magnetic Resonance Spectroscopy, Water Suppression, and Novel Approaches for Ultrashort Echo-Time Measurements

Introduction

Instrumental Impacts on Volume Definition

Factors Affecting Spectral Quality

Basic Localization 1H Mrs Methods

Acknowledgments

References

Chapter 1.3. Technical Considerations for Multivoxel Approaches and Magnetic Resonance Spectroscopic Imaging

Introduction

Multivolume Selection

Spatial Encoding

Fast Gradient-Encoding Methods

Encoding Based on Prior Knowledge

Water Suppression

Lipid Suppression

B0 Shimming

Conclusions

References

Chapter 1.4. Spectral Editing and 2D NMR

Introduction

Scalar Coupling

In Vivo GABA Editing

2D NMR Spectroscopy

References

Chapter 1.5. Spectral Quantification and Pitfalls in Interpreting Magnetic Resonance Spectroscopic Data: What To Look Out For

Introduction: A Simple Example of Spectral Quantitation

Measuring Peak Intensity

Nuisance Signals

Software Packages for Spectral Quantification

Signal Referencing and Absolute Quantification

Quality Control

Conclusions

References

Section 2: Biochemistry — What Underlies the Signal?

Chapter 2.1. N-Acetylaspartate and N-Acetylaspartylglutamate in Ce

Details

No. of pages:
398
Language:
English
Copyright:
© 2014
Published:
Imprint:
Academic Press
eBook ISBN:
9780124016972
Print ISBN:
9780124016880

About the editors

Charlotte Stagg

Affiliations and Expertise

St Edmund Hall, University of Oxford, Oxford, United Kingdom

Douglas Rothman

Affiliations and Expertise

Yale University School of Medicine, New Haven, CT, United States

Reviews

"Specialists in the neurosciences and in Magnetic Resonance Specctroscopy technology present a reference of the imaging technology for neurologists, psychiatrists, radiologists, and neuroscientists…The areas covered are technical aspects - how MRS is acquired, biochemistry - what underlies the signal, and applications of proton and non-proton MRS."--ProtoView.com, April 2014