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Life-Threatening Effects of Antipsychotic Drugs
1st Edition - August 12, 2016
Editors: Peter Manu, Robert J. Flanagan, Kathlyn J. Ronaldson
Language: English
Hardback ISBN:9780128033760
9 7 8 - 0 - 1 2 - 8 0 3 3 7 6 - 0
eBook ISBN:9780128033906
9 7 8 - 0 - 1 2 - 8 0 3 3 9 0 - 6
Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their…Read more
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Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their incidence and case fatality, and gives comprehensive advice on diagnosis, management and preventive strategies. In addition, the book discusses the benefit of antipsychotic medication in a range of therapeutic indications, and demonstrates the gain in life-expectancy associated with clozapine use in severe mental illness despite its serious, potentially life-threatening adverse effects.
Covers cardiovascular, neurological, muscular, hematological, gastrointestinal, autonomic and metabolic effects
Gives advice on risk factors, confounding diagnoses and measures to minimise seriousness
Discusses clozapine rechallenge after each of its serious adverse reactions
Makes suggestions for optimum management of somatic disease in those with severe mental illness, to improve life-expectancy
Includes data on post-mortem considerations
Psychiatrists, general and emergency physicians, pathologists, and mental health pharmacists
List of Contributors
Foreword
The Art and Science of Balance: Managing the Efficacy and Safety of Antipsychotic Drugs
Preface
Acknowledgments
Symbols and Conventions
Part I: Cardiovascular Adverse Effects of Antipsychotic Drugs
Chapter 1. Sudden Cardiac Death and Ventricular Arrhythmias
Abstract
1.1 Epidemiology
1.2 Pathobiology
1.3 Clinical and Laboratory Features
1.4 Prevention and Management
References
Chapter 2. Myocarditis and Cardiomyopathy
Abstract
2.1 Definitions
2.2 Epidemiology
2.3 Genetic Vulnerability
2.4 Pathobiology
2.5 Clinical and Laboratory Features
2.6 Differential Diagnosis
2.7 Complications and Significant Sequelae
2.8 Risk Stratification for Death or Permanent Disability
2.9 Management
2.10 Prevention
Acknowledgment
References
Chapter 3. Pulmonary Embolism
Abstract
3.1 Epidemiology
3.2 Pathobiology
3.3 Clinical and Laboratory Features
3.4 Prevention and Management
References
Chapter 4. Orthostatic Hypotension
Abstract
4.1 Epidemiology
4.2 Pathobiology
4.3 Clinical and Laboratory Features
4.4 Prevention and Management
References
Part II: Hematological Complications of Treatment With Antipsychotic Drugs
Chapter 5. Severe Neutropenia and Agranulocytosis
Abstract
5.1 Epidemiology
5.2 Pathobiology
5.3 Clinical and Laboratory Features
5.4 Prevention and Management
References
Part III: Antipsychotic-Related Pathology of the Digestive System
Chapter 6. Gastrointestinal Hypomotility and Dysphagia
Abstract
6.1 Gastrointestinal Hypomotility
6.2 Dysphagia and Sialorrhea
Acknowledgment
References
Chapter 7. Liver Failure
Abstract
7.1 Definition
7.2 Search Strategy
7.3 Epidemiology
7.4 Pathobiology
7.5 Clinical and Laboratory Features
7.6 Management
7.7 Prevention
7.8 Conclusion
References
Chapter 8. Pancreatitis
Abstract
8.1 Epidemiology
8.2 Pathobiology
8.3 Clinical and Laboratory Features
8.4 Management
References
Part IV: Major Neurological and Neuromuscular Adverse Effects of Antipsychotic Drugs
Chapter 9. Seizures
Abstract
9.1 Epidemiology
9.2 Pathobiology
9.3 Clinical and Laboratory Features
9.4 Prevention and Management
Acknowledgment
References
Chapter 10. Neuroleptic Malignant Syndrome
Abstract
10.1 Epidemiology
10.2 Pathobiology
10.3 Clinical and Laboratory Features
10.4 Prevention and Management
References
Chapter 11. Heat Stroke and Rhabdomyolysis
Abstract
11.1 Heat Stroke
11.2 Rhabdomyolysis
References
Part V: Metabolic Complications of Antipsychotic Drug Treatment
Chapter 12. Type 2 Diabetes Mellitus
Abstract
12.1 Epidemiology
12.2 Pathobiology
12.3 Clinical and Laboratory Features
12.4 Prevention and Management
12.5 Conclusion
References
Part VI: Other Life-Threatening Effects of Antipsychotic Drugs
Chapter 13. Interstitial Nephritis and Interstitial Lung Disease
Abstract
13.1 Interstitial Nephritis
13.2 Interstitial Lung Disease
References
Part VII: Clinical and Forensic Challenges in the Use of Antipsychotic Drugs
Chapter 14. The Benefits of Antipsychotic Drugs: Symptom Control and Improved Quality of Life
Abstract
14.1 Therapeutic Objectives in Schizophrenia
14.2 Pharmacology of Antipsychotic Drugs
14.3 Symptom Reduction in Schizophrenia
14.4 Relapse Prevention and Antipsychotic Maintenance Treatment
14.5 Improving Quality of Life in Patients With Schizophrenia
14.6 Antipsychotic Drugs in Treating Other Psychiatric Disorders
References
Chapter 15. Antipsychotic-Related Mortality: Risk and Strategy for Improved Clinical Management
Abstract
15.1 Reduced Life-Expectancy with Severe Mental Illness (SMI)
15.2 Suicide Reduced with Clozapine
15.3 An Obstacle to Clozapine Prescribing: Agranulocytosis
15.4 Diabetic Ketoacidosis: Poor Outcomes with Severe Mental Illness (SMI)
15.5 Strategy for Improved Outcomes
References
Further Reading
Chapter 16. Forensic Investigation of Antipsychotic-Related Deaths
Abstract
16.1 Introduction
16.2 Clinical and Pathological Correlations
16.3 Toxicological Assessments
16.4 System-Specific Forensic Considerations
16.5 Conclusions
References
Guide to the Interpretation of the Results of Some Chemical Pathology Tests
Index
No. of pages: 394
Language: English
Edition: 1
Published: August 12, 2016
Imprint: Academic Press
Hardback ISBN: 9780128033760
eBook ISBN: 9780128033906
PM
Peter Manu
Peter Manu, MD is Professor of Medicine and Psychiatry at Hofstra University School of Medicine and Adjunct Professor of Clinical Medicine, Psychiatry and Behavioral Sciences at Albert Einstein College of Medicine in New York. He aditionally serves as Director of Medical Services, Hillside Hospital, Long Island Jewish Medical Center. Prior to this, he served as the Medical Director, Alcohol and Drug Abuse Treatment Center at the University of Connecticut Health Center. In 2012 he received the Fulbright Specialist in Public/Global Health award from the U.S. Department of State. He is the author of 5 books, 68 journal articles, and 30 book chapters in psychiatry. He serves as an ad hoc reviewer for 38 journals in the areas of psychology, psychiatry, medicine, and pharmacology.
Affiliations and expertise
Hofstra Northwell School of Medicine and Albert Einstein College of Medicine, New York, NY, USA
RF
Robert J. Flanagan
Professor Bob Flanagan is Consultant Clinical Scientist and Director, Toxicology Unit, King’s College Hospital NHS Foundation Trust and Clinical Lead for Toxicology, Sheffield Teaching Hospital NHS Foundation Trust. He has published over 200 scientific papers and four books. Particular interests have been treatment of mental illness especially as regards use of antipsychotics, notably clozapine, treatment of cancer, especially in respect of the use of tyrosine kinase inhibitors such as imatinib, and the diagnosis of substance abuse, especially misuse of volatiles such as butane. He led on toxicology training for the Association for Clinical Biochemistry for many years, and regularly advises medical professionals, police, coroners, and prosecution and defence lawyers on toxicological issues. He has also acted as a consultant to the United Nations Office for Drugs and Crime, most recently as regards advising on methodology for the detection of drug-facilitated crime, and to the World Health Organization, notably in Serbia/Kosovo in 2007, and also in the Middle East and in India. He is immediate past-President of the British Academy of Forensic Sciences.
Affiliations and expertise
King's College Hospital, London, UK
KR
Kathlyn J. Ronaldson
Affiliations and expertise
Monash University, Melbourne, Australia
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