Leukocyte Membrane Determinants Regulating Immune Reactivity

Leukocyte Membrane Determinants Regulating Immune Reactivity

1st Edition - January 1, 1976

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  • Editor: Vincent P. Eijsvoogel
  • eBook ISBN: 9780323142472

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Leukocyte Membrane Determinants Regulating Immune Reactivity is a result of the Leukocyte Culture Conference meeting held at Amsterdam in 1975. Abstracts presented in the meeting are compiled in this book. The topics of these abstracts are all under leukocyte biology and include not just lymphocytes but also monocytes, macrophages, and granulocytes. The text is composed of six major sections. The first section features abstracts that deal with ligand binding and subsequent changes in membrane. Section II focuses on the receptors on lymphocytes in the context of various subpopulations. Immune reactivity, specifically its augmentation or suppression, is the main topic of Section III. Gene products are emphasized in Section IV, while effector functions of membrane determinants are tackled in Section V. Finally, Section VI features leukocyte membrane determinants in differentiation and maturation. The book presents much detailed information that will be of great help to students or professionals in the study of biology, specifically leukocyte biology.

Table of Contents

  • Preface


    Section I. Ligand Binding and Subsequent Changes in Membrane Properties

    Control of the Lateral Mobility of Membrane Proteins

    Modulation of Lymphocyte Mitogenesis

    Reversible Modifications of Cell Membrane Structures Induced by Antibodies against Transplantation Antigens of Man

    Interaction of Non-Mitogenic and Mitogenic Lectins with T Lymphocytes. Association of Cellular Receptor Sites

    Dynamic Behaviour of Concanavalin Receptor Sites on Rat Lymphocytes

    Mechanisms of Lymphocyte Activation. II. Negative Cooperativity in the Binding of Phytohemagglutinin (PHA) to Its Lymphocyte Receptors

    The Role of Some Membrane-Related Events in B Lymphocyte Activation by Antigen

    Dissociation of Mitogenic and Immunogenic Activities of DNP-Levan Conjugates for B Cells in Mice

    Lymphocyte Triggering by Bacterial LPS. Dissociation between Immunogenicity of TNP-LPS and Mitogenic and Complement Activating Properties

    Inhibition of LPS Mitogenicity by Polymyxin B Results in Loss of Immunogenicity of Hapten-LPS Conjugates

    Differential Inhibitory Effects of Chlorpromazine on the Responses of Lymphocytes to Mitogens and Allogeneic Cells

    Properties of Thymocyte Membrane Areas Bearing Concanavalin A Receptors of High Affinity

    Interaction of Lectins with Human Lymphocytes Studied by a Surface-Labeling Technique

    The Fate of IgM and of Anti IgM on Antibody-Coated Daudi Cells

    Antibody Induced Changes in the Expression of Membranal Receptors and Antigen Receptors in Lymphocytes

    Differential Effects of a Mushroom Lectin (AbL) on Parameters of Lymphocyte Activation

    Differential Agglutination of Murine Lymphoid Cells by an Invertebrate Lectin (LAgl)

    Modulation of Interaction of WGA with Membrane Receptor Sites by a Membrane Mobility Agent and by Trypsin

    Inhibition of Lymphocyte Mitogenesis by Immobilized Antigen-Antibody Complexes

    Prolongation of Mitogenic Capacity of Periodate Treated Lymphocytes by Exposure to Glutaraldehyde

    Cytoplasmic Cooperation Induced between Mitogen Stimulated Immune Cells

    Potentiation of Cyclic AMP (cAMP) Generation in Leukocytes by Combination of Concanavalin A (Con A) with Prostaglandins (PG)

    Ion Distribution Patterns in Human Lymphocytes: The Effects of Concanavalin A and Ouabain

    Calcium Ionophore A23187 and Lymphocyte Activation

    The Role of Divalent Cations in the Initiation of Lymphocyte Activation

    Section II. (Antigen) Receptors on Lymphocytes of Different Subpopulations

    Characteristics of Idiotype-Positive T Lymphocytes and the Use of Anti-Idiotypic Antibodies to Selectively Inhibit T Cell Function

    Idiotypic Identity of Strep. A. Specific Antigen Recognition Sites on Mouse T and B-Lymphocytes

    Shedding of T Lymphocyte Receptors for Alloantigens

    Functional Studies of Lymphoid Cells Defined and Isolated by a Fluorescence Activated Cell Sorter (FACS) from Normal and Athymic Mice

    Density of Surface Ig on B-Cells: Ontogenic Studies of a Population of Splenic B-Cells in Normal Mice and Mice with an X-Linked B-Lymphocyte Immune Defect

    Selective Recruitment In Vivo of Subsets of Recirculating Lymphocytes Reactive to H2 Determinants

    Cell Surface Immunoglobulin of Mouse T Lymphoma Cells and Cultured Fetal Thymocytes

    Studies on the Expression of Cell Surface Determinants on Activated Mouse Lymphocytes

    Origin and Specificity of Surface Immunoglobulin on MLR Activated Mouse T Cells

    Active and Passive Thyroglobulin-Rosette Forming Cells in Obese Strain (OS) Chickens with Spontaneous Autoimmune Thyroiditis

    Antigen-Binding Lymphocytes in Mice with an X-Linked B-Lymphocyte Defect

    Evaluation of Polyclonal B Cell Activators (PBA) with Chromosomally Marked Cell Populations

    Quantitative Analysis of Cellular and Humoral Immunoglobulin in Bursectomized Chickens

    The Presence of IgG Affinity on Human Lymphocytes Bearing Both Complement and SRBC Receptors

    Studies on the Fc Receptor of Human Peripheral Blood Monocytes and Peritoneal Macrophages: Possible Evidence for Inducibility

    Behavior and Fine Structure of Human Fc Receptor-Bearing Lymphocytes Adherent to Immobilized Antigen-Antibody Complexes

    Regeneration of Antigen-Binding Receptors on B Lymphocytes

    Kinetic Studies of T and B Lymphocyte Membrane Markers in Mitogen Induced Proliferation

    Isolation and Characterization of Phytohemagglutinin-Responsive, Concanavalin A-Nonresponsive Human T Lymphocytes

    Murine T-Cell Lymphomas, a Model System for Mouse T Cells

    Human Lymphocyte Subpopulations

    Section III. Augmentation versus Suppression of Immune Reactivity Controlled by Leukocyte Membrane Determinants

    Cell Cooperation Mediated by Products of Genes in the Major Histocompatibility Complex

    Control of Immunocompetent Cell Differentiation and Function by Products of the Major Histocompatibility Gene Complex

    A Soluble Suppressor of T Cell Response In Vitro: Characterization and Genetic Restriction of Activity

    Suppression of Immunoglobulin Synthesis in Vitro by Purified Antibody to IgD

    No Histocompatibility Requirements for Macrophage-Lymphocyte Interactions in the Primary Immune Antibody Response to Sheep Erythrocytes In Vitro

    Characterization of Macrophage Derived Factors Effective in T-Helper Cell Induction

    Dissection of the Role of Accessory Cells in Phytohemagglutinin-Induced T Lymphocyte Proliferation

    Suppression of In Vitro Antibody Synthesis by a T Cell Product. Its Relation with the Fc Receptor of Activated T Cells

    Amplification or Controlling Genes in Cell Mediated Lympholysis

    Interaction of C-Reactive Protein (CRP) with Lymphocytes and Monocytes: Complement Dependent Opsonic Adherence and Phagocytosis

    Cell Activation Due to an 'M' Locus Product on Murine B Cells in a GVH Model without Killer Cell Generation

    Tropism of Surface Immunoglobulins May Help Determine Isogeneic and Allogeneic Lymphocyte Interactions

    In Vitro Generation of Suppressor Cell Activity Suppression of in Vitro CML Induction

    Demonstration of Human Culture PFC (HcPFC) and Suppressor Lymphocytes in Congenital Agammaglobulinemia (Aγ) and Common Variable Dysgammaglobulinemia (DYSγ)

    In Vitro Studies on the Cellular Basis of the Unresponsiveness in Mice to (TG)AL

    Macrophage Mediated Inhibition of Lymphocyte Blastogenesis

    Absolute Macrophage Requirement for T-Lymphocyte Activation by Mitogens

    Section IV. Gene Products of the Major Histocompatibility Complex in the Immune Response

    Cellular Expression of Ia Antigens and Their Possible Role in Immune Reactions

    Murine Ia Antigens. Expression on T and B Cells and Their Role in Immune Response

    Structural Characteristics of Guinea Pig Major Histocompatibility Complex Alloantigens

    Inhibition of Rat Lymphocyte Function In Vitro by Alloantisera

    Differential Function of MHC LD and SD Determinants

    H-2 Linked Bifunctional Genetic Control of Cell-Mediated Lympholysis to TNP-Modified Autologous Cell Surfaces

    What Can One Learn about Lymphocytes by Studying H-2 Mutations

    Analysis of H-2 Mutants. Cell Mediated Reactivity of the H-2BE Variant and Four Z-1 Locus Mutants

    Tissue-Specific Expression of H-2 Immunogenicity

    Functionally Different T Lymphocyte Subclasses Share an Identical Constant Receptor Part

    The Production of Anti-T Cell Receptor Sera in the Guinea Pig

    Recognition by Pregnancy Serums of Several Distinct Non-HL-A Alloantigens Expressed on B Cells and Their Relationship to LD Determinants

    The Effect of Prolonged Ouabain Treatment and of Protease Inhibitors on the Mixed Lymphocyte Reaction (MLR)

    B Lymphocyte Alloantigens in Man: Evidence for Linkage to HL-A

    Serotyping for LD: Evidence for a "New" Locus in HLA

    Inconsistencies between LD Phenotypes and the Predicted Mixed Lymphocyte Reaction (MLR)

    Are MLR-R and MLR-S Gene Products Expressed on Two Different Cell Types?

    The Nature of MLC Blocking Antibodies in Man

    Inhibition of Fc Receptors, MLC, and Rat Renal Allograft Rejection by Allo-Antisera Lacking Anti-Ag-B Serological Specificity

    The Mixed Kidney Cell-Lymphocyte Culture Reaction in Rats

    Use of Immune Precipitation to Identify and Suggest Mapping Position for New la Specificities

    Genetic Control of Host versus Graft and Graft versus Host Reactions in Dogs Bone Marrow Transplantation

    The Major Histocompatibility Complex of the Rat

    Histocompatibility Antigens of the Guinea-Pig

    Further Evidence for Clonal Deletion of Host Reactive T Cells in X-Irradiation Chimeras

    Dissociation of Functional Responses of Lymphocyte Subpopulations

    Secondary T-Cell Cytotoxicity: Role of LD and SD Antigens

    H-2 Restricted T-Cell Cytotoxic Responses to H-Y Antigen

    Cell-Mediated Lympholysis in Canine Littermates

    Further Studies on T-Memory Cells Primed to Histoincompatible Cells

    A New CML Antigen Linked to the MHC of Man

    Relationships of Secondary In Vitro CML to Short-Term Memory to Human Allo-Antigens

    Cluster Forming Cells (CFC) Can Measure Stimulation in MLR

    Quantitation of Lymphocyte Blast Transformation by Flow Cytofluorometry

    Tyrosine Peptide Homologies in the HLA Antigen System

    Cell-Cell Interaction in Calf and Human Lymphocytes Transformed by Sodium Periodate

    Section V. Mediation of Effector Functions by Membrane Determinants in Different Leukocyte (SUB)Populations

    Cell Surface Stimulation and Ligand Binding Determine Polymorphonuclear Leukocyte Function

    Two Independent Recognition Sites for the Initiation of Histamine Release from Mast Cells

    Activators of Neutrophils and K Cells

    Analysis of Antibody Dependent Lymphocytic Effector Cells (K-Cells) in Human Blood by a Plaque Assay

    Interactions of Initiator and Recruited T Lymphocytes in Cell-Mediated Immunity

    T-T Cell Interactions during in Vitro Cytotoxic Allograft Responses

    Specific Gel Precipitation of a T Cell Membrane Component Involved in T Cell-Mediated Killing

    Heterogeneity of Human Lymphoid Cells Binding the Fc Region of IgG

    Origin of Effector Cells and Mechanism of Lymphocyte-Dependent Antibody Cytotoxicity in Rabbit

    Relation between Receptor Binding, Phagocytosis and Effector Function of Human Polymorphonuclear Leukocytes

    The Effect of Factors Influencing Cellular cAMP on Phagocytosis and Lysosomal Enzyme Release by Mouse Macrophages

    Effect of Corticosteroids on Macrophage Arming

    K Cell Cytotoxicity: Studies into Nature of Kill Phase

    Cytotoxic Effector Cells in the Bone Marrow of Normal Humans

    Initiation of Suppression of the Cytotoxic Lymphocyte Response

    Species-Specific Lymphocyte-Target Cell Interaction In Vitro

    Intrinsic and Acquired Cytotoxic Specificity of Activated Human Lymphocytes

    The Cytotoxic Activity of Different Rat Lymphocyte Subpopulations Sensitized In Vitro

    Strong Proliferative Response, but Lack of Cytotoxic Effector Cell Generation to Syngeneic RCS Tumor in Lymphoid Cells from Normal and Immune SJL/J Mice

    Characterization of Anti-MSV Cytotoxic Lymphocytes Generated in Secondary Mixed Leukocyte-Tumor Cell Cultures

    Changes in Murine Lymphocyte Surface Topography Induced by Friend Virus Infection

    Sequential Changes in Lymphocyte Responses to Herpes Simplex Virus in Patients with Recurrent Herpetic Infection

    Localization of the IgG Effector Site for Monocyte Receptors

    Monocyte-Mediated Lysis of Human Erythrocytes

    In Vitro Studies on Endocytosis and Lysosomal Function on Rat Kupffer Cells

    Phagocytosis of DNA-Anti-DNA Complexes by Human PMN via Fc and C3 Receptor

    Sponge Matrix Allografts: Isolation and Preliminary In Vitro Characterization of Killer Cells Infiltrating Mouse Allografts

    Separate Membrane Receptors on Activated T Cells Determine the Specificity of Cell-Mediated Cytolysis

    Fc-Receptor Negative Lymphocyte Populations as Effector Cells in Human Antibody-Dependent Cell-Mediated Cytotoxicity (ADCMC)

    Section VI. Leukocyte Membrane Determinants in Differentiation and Maturation

    B-Lymphocyte Colony Formation In Vitro

    Membrane Receptors on Mouse Bone Marrow Colony Cells Grown In Vitro

    Functional Studies of the Ontogeny of the M-Locus Product: A Surface Antigen of Murine B Lymphocytes

    Induction of Human T-Lymphocyte Differentiation Antigens

    Induction of Surface Receptors on Granulocyte, T, and B Cell Precursors in Human Bone Marrow by Thymic and Non-Thymic Agents

    Tissue Factors Stimulating or Inhibiting Growth of Human T Lymphocyte Colonies

    Isolation and Maturation-Sequence of Two Populations of Rabbit B Cells

    Binding of Autologous Erythrocytes to Immature T-Cells

    Development of a Specific Antibody Marker for Circulating Human Monocytes and Tissue Macrophages

    Workshop Reports

    Cell Separation on the Basis of Receptor Affinity. I. The Chemistry of Solid Support Derivatisation for Immunoadsorption

    Typing of Human MLC Determinants

    Recognition of Leukocyte Subpopulations by Cell Specific Membrane Antigens

    Differentiation of T-Cells and Their Membrane Determinants

    Regulation of Lymphocyte Metabolism

    Antibody-Dependent Cytotoxic Activity as a Property of Fc Receptor Cells

    Primary and Secondary Stimulation in MLR and CML

    Human Leukocyte Subpopulation Markers

    Macrophage-Lymphocyte Interaction

    Isolation and Identification of Leukocyte Membrane Determinants

    Interaction between Viruses and Lymphocytes

    Cell Separation on the Basis of Receptor Affinity. II. The Recognition and Isolation of Lymphocyte Subsets

Product details

  • No. of pages: 798
  • Language: English
  • Copyright: © Academic Press 1976
  • Published: January 1, 1976
  • Imprint: Academic Press
  • eBook ISBN: 9780323142472

About the Editor

Vincent P. Eijsvoogel

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