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Leukocyte Membrane Determinants Regulating Immune Reactivity - 1st Edition - ISBN: 9780122337505, 9780323142472

Leukocyte Membrane Determinants Regulating Immune Reactivity

1st Edition

Editor: Vincent P. Eijsvoogel
eBook ISBN: 9780323142472
Imprint: Academic Press
Published Date: 1st January 1976
Page Count: 798
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Leukocyte Membrane Determinants Regulating Immune Reactivity is a result of the Leukocyte Culture Conference meeting held at Amsterdam in 1975. Abstracts presented in the meeting are compiled in this book. The topics of these abstracts are all under leukocyte biology and include not just lymphocytes but also monocytes, macrophages, and granulocytes. The text is composed of six major sections. The first section features abstracts that deal with ligand binding and subsequent changes in membrane. Section II focuses on the receptors on lymphocytes in the context of various subpopulations. Immune reactivity, specifically its augmentation or suppression, is the main topic of Section III. Gene products are emphasized in Section IV, while effector functions of membrane determinants are tackled in Section V. Finally, Section VI features leukocyte membrane determinants in differentiation and maturation. The book presents much detailed information that will be of great help to students or professionals in the study of biology, specifically leukocyte biology.

Table of Contents



Section I. Ligand Binding and Subsequent Changes in Membrane Properties

Control of the Lateral Mobility of Membrane Proteins

Modulation of Lymphocyte Mitogenesis

Reversible Modifications of Cell Membrane Structures Induced by Antibodies against Transplantation Antigens of Man

Interaction of Non-Mitogenic and Mitogenic Lectins with T Lymphocytes. Association of Cellular Receptor Sites

Dynamic Behaviour of Concanavalin Receptor Sites on Rat Lymphocytes

Mechanisms of Lymphocyte Activation. II. Negative Cooperativity in the Binding of Phytohemagglutinin (PHA) to Its Lymphocyte Receptors

The Role of Some Membrane-Related Events in B Lymphocyte Activation by Antigen

Dissociation of Mitogenic and Immunogenic Activities of DNP-Levan Conjugates for B Cells in Mice

Lymphocyte Triggering by Bacterial LPS. Dissociation between Immunogenicity of TNP-LPS and Mitogenic and Complement Activating Properties

Inhibition of LPS Mitogenicity by Polymyxin B Results in Loss of Immunogenicity of Hapten-LPS Conjugates

Differential Inhibitory Effects of Chlorpromazine on the Responses of Lymphocytes to Mitogens and Allogeneic Cells

Properties of Thymocyte Membrane Areas Bearing Concanavalin A Receptors of High Affinity

Interaction of Lectins with Human Lymphocytes Studied by a Surface-Labeling Technique

The Fate of IgM and of Anti IgM on Antibody-Coated Daudi Cells

Antibody Induced Changes in the Expression of Membranal Receptors and Antigen Receptors in Lymphocytes

Differential Effects of a Mushroom Lectin (AbL) on Parameters of Lymphocyte Activation

Differential Agglutination of Murine Lymphoid Cells by an Invertebrate Lectin (LAgl)

Modulation of Interaction of WGA with Membrane Receptor Sites by a Membrane Mobility Agent and by Trypsin

Inhibition of Lymphocyte Mitogenesis by Immobilized Antigen-Antibody Complexes

Prolongation of Mitogenic Capacity of Periodate Treated Lymphocytes by Exposure to Glutaraldehyde

Cytoplasmic Cooperation Induced between Mitogen Stimulated Immune Cells

Potentiation of Cyclic AMP (cAMP) Generation in Leukocytes by Combination of Concanavalin A (Con A) with Prostaglandins (PG)

Ion Distribution Patterns in Human Lymphocytes: The Effects of Concanavalin A and Ouabain

Calcium Ionophore A23187 and Lymphocyte Activation

The Role of Divalent Cations in the Initiation of Lymphocyte Activation

Section II. (Antigen) Receptors on Lymphocytes of Different Subpopulations

Characteristics of Idiotype-Positive T Lymphocytes and the Use of Anti-Idiotypic Antibodies to Selectively Inhibit T Cell Function

Idiotypic Identity of Strep. A. Specific Antigen Recognition Sites on Mouse T and B-Lymphocytes

Shedding of T Lymphocyte Receptors for Alloantigens

Functional Studies of Lymphoid Cells Defined and Isolated by a Fluorescence Activated Cell Sorter (FACS) from Normal and Athymic Mice

Density of Surface Ig on B-Cells: Ontogenic Studies of a Population of Splenic B-Cells in Normal Mice and Mice with an X-Linked B-Lymphocyte Immune Defect

Selective Recruitment In Vivo of Subsets of Recirculating Lymphocytes Reactive to H2 Determinants

Cell Surface Immunoglobulin of Mouse T Lymphoma Cells and Cultured Fetal Thymocytes

Studies on the Expression of Cell Surface Determinants on Activated Mouse Lymphocytes

Origin and Specificity of Surface Immunoglobulin on MLR Activated Mouse T Cells

Active and Passive Thyroglobulin-Rosette Forming Cells in Obese Strain (OS) Chickens with Spontaneous Autoimmune Thyroiditis

Antigen-Binding Lymphocytes in Mice with an X-Linked B-Lymphocyte Defect

Evaluation of Polyclonal B Cell Activators (PBA) with Chromosomally Marked Cell Populations

Quantitative Analysis of Cellular and Humoral Immunoglobulin in Bursectomized Chickens

The Presence of IgG Affinity on Human Lymphocytes Bearing Both Complement and SRBC Receptors

Studies on the Fc Receptor of Human Peripheral Blood Monocytes and Peritoneal Macrophages: Possible Evidence for Inducibility

Behavior and Fine Structure of Human Fc Receptor-Bearing Lymphocytes Adherent to Immobilized Antigen-Antibody Complexes

Regeneration of Antigen-Binding Receptors on B Lymphocytes

Kinetic Studies of T and B Lymphocyte Membrane Markers in Mitogen Induced Proliferation

Isolation and Characterization of Phytohemagglutinin-Responsive, Concanavalin A-Nonresponsive Human T Lymphocytes

Murine T-Cell Lymphomas, a Model System for Mouse T Cells

Human Lymphocyte Subpopulations

Section III. Augmentation versus Suppression of Immune Reactivity Controlled by Leukocyte Membrane Determinants

Cell Cooperation Mediated by Products of Genes in the Major Histocompatibility Complex

Control of Immunocompetent Cell Differentiation and Function by Products of the Major Histocompatibility Gene Complex

A Soluble Suppressor of T Cell Response In Vitro: Characterization and Genetic Restriction of Activity

Suppression of Immunoglobulin Synthesis in Vitro by Purified Antibody to IgD

No Histocompatibility Requirements for Macrophage-Lymphocyte Interactions in the Primary Immune Antibody Response to Sheep Erythrocytes In Vitro

Characterization of Macrophage Derived Factors Effective in T-Helper Cell Induction

Dissection of the Role of Accessory Cells in Phytohemagglutinin-Induced T Lymphocyte Proliferation

Suppression of In Vitro Antibody Synthesis by a T Cell Product. Its Relation with the Fc Receptor of Activated T Cells

Amplification or Controlling Genes in Cell Mediated Lympholysis

Interaction of C-Reactive Protein (CRP) with Lymphocytes and Monocytes: Complement Dependent Opsonic Adherence and Phagocytosis

Cell Activation Due to an 'M' Locus Product on Murine B Cells in a GVH Model without Killer Cell Generation

Tropism of Surface Immunoglobulins May Help Determine Isogeneic and Allogeneic Lymphocyte Interactions

In Vitro Generation of Suppressor Cell Activity Suppression of in Vitro CML Induction

Demonstration of Human Culture PFC (HcPFC) and Suppressor Lymphocytes in Congenital Agammaglobulinemia (Aγ) and Common Variable Dysgammaglobulinemia (DYSγ)

In Vitro Studies on the Cellular Basis of the Unresponsiveness in Mice to (TG)AL

Macrophage Mediated Inhibition of Lymphocyte Blastogenesis

Absolute Macrophage Requirement for T-Lymphocyte Activation by Mitogens

Section IV. Gene Products of the Major Histocompatibility Complex in the Immune Response

Cellular Expression of Ia Antigens and Their Possible Role in Immune Reactions

Murine Ia Antigens. Expression on T and B Cells and Their Role in Immune Response

Structural Characteristics of Guinea Pig Major Histocompatibility Complex Alloantigens

Inhibition of Rat Lymphocyte Function In Vitro by Alloantisera

Differential Function of MHC LD and SD Determinants

H-2 Linked Bifunctional Genetic Control of Cell-Mediated Lympholysis to TNP-Modified Autologous Cell Surfaces

What Can One Learn about Lymphocytes by Studying H-2 Mutations

Analysis of H-2 Mutants. Cell Mediated Reactivity of the H-2BE Variant and Four Z-1 Locus Mutants

Tissue-Specific Expression of H-2 Immunogenicity

Functionally Different T Lymphocyte Subclasses Share an Identical Constant Receptor Part

The Production of Anti-T Cell Receptor Sera in the Guinea Pig

Recognition by Pregnancy Serums of Several Distinct Non-HL-A Alloantigens Expressed on B Cells and Their Relationship to LD Determinants

The Effect of Prolonged Ouabain Treatment and of Protease Inhibitors on the Mixed Lymphocyte Reaction (MLR)

B Lymphocyte Alloantigens in Man: Evidence for Linkage to HL-A

Serotyping for LD: Evidence for a "New" Locus in HLA

Inconsistencies between LD Phenotypes and the Predicted Mixed Lymphocyte Reaction (MLR)

Are MLR-R and MLR-S Gene Products Expressed on Two Different Cell Types?

The Nature of MLC Blocking Antibodies in Man

Inhibition of Fc Receptors, MLC, and Rat Renal Allograft Rejection by Allo-Antisera Lacking Anti-Ag-B Serological Specificity

The Mixed Kidney Cell-Lymphocyte Culture Reaction in Rats

Use of Immune Precipitation to Identify and Suggest Mapping Position for New la Specificities

Genetic Control of Host versus Graft and Graft versus Host Reactions in Dogs Bone Marrow Transplantation

The Major Histocompatibility Complex of the Rat

Histocompatibility Antigens of the Guinea-Pig

Further Evidence for Clonal Deletion of Host Reactive T Cells in X-Irradiation Chimeras

Dissociation of Functional Responses of Lymphocyte Subpopulations

Secondary T-Cell Cytotoxicity: Role of LD and SD Antigens

H-2 Restricted T-Cell Cytotoxic Responses to H-Y Antigen

Cell-Mediated Lympholysis in Canine Littermates

Further Studies on T-Memory Cells Primed to Histoincompatible Cells

A New CML Antigen Linked to the MHC of Man

Relationships of Secondary In Vitro CML to Short-Term Memory to Human Allo-Antigens

Cluster Forming Cells (CFC) Can Measure Stimulation in MLR

Quantitation of Lymphocyte Blast Transformation by Flow Cytofluorometry

Tyrosine Peptide Homologies in the HLA Antigen System

Cell-Cell Interaction in Calf and Human Lymphocytes Transformed by Sodium Periodate

Section V. Mediation of Effector Functions by Membrane Determinants in Different Leukocyte (SUB)Populations

Cell Surface Stimulation and Ligand Binding Determine Polymorphonuclear Leukocyte Function

Two Independent Recognition Sites for the Initiation of Histamine Release from Mast Cells

Activators of Neutrophils and K Cells

Analysis of Antibody Dependent Lymphocytic Effector Cells (K-Cells) in Human Blood by a Plaque Assay

Interactions of Initiator and Recruited T Lymphocytes in Cell-Mediated Immunity

T-T Cell Interactions during in Vitro Cytotoxic Allograft Responses

Specific Gel Precipitation of a T Cell Membrane Component Involved in T Cell-Mediated Killing

Heterogeneity of Human Lymphoid Cells Binding the Fc Region of IgG

Origin of Effector Cells and Mechanism of Lymphocyte-Dependent Antibody Cytotoxicity in Rabbit

Relation between Receptor Binding, Phagocytosis and Effector Function of Human Polymorphonuclear Leukocytes

The Effect of Factors Influencing Cellular cAMP on Phagocytosis and Lysosomal Enzyme Release by Mouse Macrophages

Effect of Corticosteroids on Macrophage Arming

K Cell Cytotoxicity: Studies into Nature of Kill Phase

Cytotoxic Effector Cells in the Bone Marrow of Normal Humans

Initiation of Suppression of the Cytotoxic Lymphocyte Response

Species-Specific Lymphocyte-Target Cell Interaction In Vitro

Intrinsic and Acquired Cytotoxic Specificity of Activated Human Lymphocytes

The Cytotoxic Activity of Different Rat Lymphocyte Subpopulations Sensitized In Vitro

Strong Proliferative Response, but Lack of Cytotoxic Effector Cell Generation to Syngeneic RCS Tumor in Lymphoid Cells from Normal and Immune SJL/J Mice

Characterization of Anti-MSV Cytotoxic Lymphocytes Generated in Secondary Mixed Leukocyte-Tumor Cell Cultures

Changes in Murine Lymphocyte Surface Topography Induced by Friend Virus Infection

Sequential Changes in Lymphocyte Responses to Herpes Simplex Virus in Patients with Recurrent Herpetic Infection

Localization of the IgG Effector Site for Monocyte Receptors

Monocyte-Mediated Lysis of Human Erythrocytes

In Vitro Studies on Endocytosis and Lysosomal Function on Rat Kupffer Cells

Phagocytosis of DNA-Anti-DNA Complexes by Human PMN via Fc and C3 Receptor

Sponge Matrix Allografts: Isolation and Preliminary In Vitro Characterization of Killer Cells Infiltrating Mouse Allografts

Separate Membrane Receptors on Activated T Cells Determine the Specificity of Cell-Mediated Cytolysis

Fc-Receptor Negative Lymphocyte Populations as Effector Cells in Human Antibody-Dependent Cell-Mediated Cytotoxicity (ADCMC)

Section VI. Leukocyte Membrane Determinants in Differentiation and Maturation

B-Lymphocyte Colony Formation In Vitro

Membrane Receptors on Mouse Bone Marrow Colony Cells Grown In Vitro

Functional Studies of the Ontogeny of the M-Locus Product: A Surface Antigen of Murine B Lymphocytes

Induction of Human T-Lymphocyte Differentiation Antigens

Induction of Surface Receptors on Granulocyte, T, and B Cell Precursors in Human Bone Marrow by Thymic and Non-Thymic Agents

Tissue Factors Stimulating or Inhibiting Growth of Human T Lymphocyte Colonies

Isolation and Maturation-Sequence of Two Populations of Rabbit B Cells

Binding of Autologous Erythrocytes to Immature T-Cells

Development of a Specific Antibody Marker for Circulating Human Monocytes and Tissue Macrophages

Workshop Reports

Cell Separation on the Basis of Receptor Affinity. I. The Chemistry of Solid Support Derivatisation for Immunoadsorption

Typing of Human MLC Determinants

Recognition of Leukocyte Subpopulations by Cell Specific Membrane Antigens

Differentiation of T-Cells and Their Membrane Determinants

Regulation of Lymphocyte Metabolism

Antibody-Dependent Cytotoxic Activity as a Property of Fc Receptor Cells

Primary and Secondary Stimulation in MLR and CML

Human Leukocyte Subpopulation Markers

Macrophage-Lymphocyte Interaction

Isolation and Identification of Leukocyte Membrane Determinants

Interaction between Viruses and Lymphocytes

Cell Separation on the Basis of Receptor Affinity. II. The Recognition and Isolation of Lymphocyte Subsets


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© Academic Press 1976
1st January 1976
Academic Press
eBook ISBN:

About the Editor

Vincent P. Eijsvoogel

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