Laboratory Investigation of Endocrine Disorders

Laboratory Investigation of Endocrine Disorders

2nd Edition - May 17, 1983

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  • Authors: Michael R. Wills, Bill Havard
  • eBook ISBN: 9781483182605

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Description

Laboratory Investigation of Endocrine Disorders, Second Edition serves as a basic guide to the available endocrine laboratory tests. This book discusses the developments in the understanding of the mechanisms involved in the pathogenesis of endocrine disorders. Organized into 9 chapters, this edition begins with an overview of the control of thyroid hormone secretion. This text then explains the role of hypothalamus in the control of the activities of the functionally distinct anterior and posterior lobes of the pituitary gland. Other chapters consider the disorders of calcium homeostasis and their investigation with specific reference to hypocalcemia and hypercalcemia. This book discusses as well the adrenal cortical function. The final chapter deals with the normal steady-state regulation of calcium, which includes diet, physiological mechanisms, and hormones. This book is a valuable resource for laboratory-based scientists, both the medical and the non-medical. Senior clinical students and medical practitioners will also find this book useful.

Table of Contents


  • 1. Thyroid Disorders

    Physiology

    Specimens and Normal Range Values

    Total Serum Thyroxine (T4)

    Total Serum Tri-Iodothyronine (T3)

    Free Binding Capacity (FBC)

    Free Thyroxine Index (FTI)

    Thyrotrophin (TSH)

    In Vivo Tests

    99mTc Uptake

    Thyroid Scan

    Thyrotrophin-Releasing Hormone (TRH) Test

    Other Tests

    Thyroid Antibodies in Thyroiditis

    Thyroid-Stimulating Antibodies (TSAB)

    Cholesterol

    Diagnostic Considerations

    Hypothyroidism

    Hyperthyroidism

    Investigation of Thyroid Status in Patients after Treatment of Hyperthyroidism

    Investigation of Thyroid Status in Patients after Treatment of Hypothyroidism

    2. Hypothalamic-Anterior Pituitary Disorders

    Physiology

    Specimens and Normal Range Values

    Growth Hormone

    Follicle-Stimulating and Luteinizing Hormones

    Prolactin

    Adrenocorticotrophin

    Dynamic Tests

    LH-RH Test

    Combined Test

    Diagnostic Considerations

    Hypopituitarism

    Growth Hormone Excess

    Galactorrhoea

    Precocious Puberty

    3. Hypothalamic-Pituitary-Adrenocortical Axis

    Physiology

    Specimens and Normal Range Values

    Plasma Cortisol

    Urine for Steroids

    Normal Range Values

    Dynamic Tests

    Tetracosactrin

    Dexamethasone Suppression Tests

    Metyrapone Test

    Diagnostic Considerations

    Adrenocortical Hyperplasia (Cushing's Syndrome)

    Adrenocortical Hypofunction

    4. Hypothalamic-Posterior Pituitary Disorders

    Physiology

    Specimens and Normal Range Values

    Diagnostic Considerations

    Diabetes Insipidus

    Inappropriate ADH Syndrome

    5. Adrenal Cortical Disorders

    Physiology

    Specimens and Normal Range Values

    Plasma Cortisol

    Plasma Renin and Aldosterone

    Plasma 17-α-Hydroxyprogesterone

    Urine Pregnanetriol

    Urine 11-Oxygénation Index

    Diagnostic Considerations

    Primary Adrenocortical Hypofunction (Addison's Disease)

    Secondary Adrenocortical Hypofunction

    Congenital Adrenal Hyperplasia

    Primary Hyperaldosteronism (Conn's Syndrome)

    Secondary Hyperaldosteronism

    Hypoaldosteronism

    6. Disorders of the Adrenal Medulla

    Physiology

    Specimens and Normal Range Values

    Plasma

    Urine

    Diagnostic Considerations

    Phaeochromocytoma

    7. Ovarian Disorders

    Physiology

    Gametogenesis

    Secretion of Oestrogens

    Specimens and Normal Range Values

    Oestradiol-17-ß

    Progesterone

    Pregnanediol

    Urine Total Oestrogens in the Non-Pregnant

    Urine Total Oestrogens in Pregnancy

    Dynamic Tests

    Clomiphene Stimulation Test

    LH-RH Test

    Human Menopausal Gonadotrophin Stimulation

    Clinical Considerations

    Amenorrhoea

    Infertility

    Hyperprolactinaemic Hypogonadism

    Precocious Puberty

    Hirsuties and Virilism

    8. Testicular Disorders

    Physiology

    Specimens and Normal Range Values

    Plasma LH and FSH

    Plasma Testosterone

    Urine 17-Oxosteroids

    Dynamic Tests

    Clomiphene Stimulation Test

    HCG Stimulation Test

    Diagnostic Considerations

    Infertility

    Hypogonadism

    Precocious Puberty

    9. Disorders of Calcium Homeostasis

    Physiology

    Specimens and Normal Range Values

    Calcium (Total)

    Calcium (Ionized)

    Plasma Phosphorus

    Phosphate Excretion Tests

    Magnesium

    Serum Proteins and Albumin

    Alkaline Phosphatase

    Parathyroid Hormone

    25-Hydroxyvitamin D and 1,25 Dihydroxycholecalciferol

    Calcitonin

    Urine Calcium

    Urine Hydroxyproline

    Urine Cyclic AMP

    Dynamic Tests

    Cortisone Suppression Test

    Diagnostic Considerations

    Hypercalcaemia

    Hypocalcaemia

    Appendix Normal Reference Values and Factors for the Conversion of Conventional to Si Units

Product details

  • No. of pages: 126
  • Language: English
  • Copyright: © Butterworth-Heinemann 1983
  • Published: May 17, 1983
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483182605

About the Authors

Michael R. Wills

Bill Havard

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