Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement.
In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney.
- Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair
- Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation
- Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research
- Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function
Clinicians and clinical researchers in renal transplant, organ transplant, nephrology, and biomedical engineering
PART I: Kidney Transplantation
Section I: Epidemiology of kidney disease and transplantation
Section II: Donor selection and allocation
Section III: Kidney preservation and transplant procedures
Section IV: Kidney recipients and transplant
Section V: Transplantation immunology and immunomodulation
Section VI: Graft monitoring tools
Section VII: Post-transplant immune events
Section VIII: Early and late complications
Section IX: Long-term outcomes
Section X: Transplant issues and specific patients
Section XI: Ethics and costs
Section XII: Unmet needs
PART II: Kidney Bioengineering and Repair
Section I: Introduction
Section II: Bioengineering
Section III: Bioreactors and biomaterials
Section IV: Regeneration
Section V: Adult cells for regeneration
Section VI: Cell therapy for renal tissue repair
Section VII: Future Perspectives
- No. of pages:
- © Academic Press 2017
- 6th July 2017
- Academic Press
- eBook ISBN:
- Hardcover ISBN:
Transplant surgeon scientist, specializing in kidney and pancreas transplantation, as well as in abdominal organ bioengineering and regeneration. My main achievements have been in the field of steroid-free immunosuppression (IS), IS minimization and clinical tolerance after liver transplantation, as well as in the development of platforms for renal, small bowel and endocrine pancreas bioengineering and regeneration research. The main goal of my investigations is to bio-engineer and implant in humans renal organoids, insulin-producing cells and segments of small bowel. The ability to produce kidneys, insulin-producing cells and small bowel from patient’s own cells will revolutionize transplant medicine. The main goal of my scientific production is to orchestrate the transition of organ transplantation towards a regenerative medicine-focused type of research.
I originally hail from Rome, Italy, where I grew up, matriculated, attended medical school, and received training in general and transplant surgery. I also participated in fellowships in Paris (Liver Unit, Paul Brousse Hospital, Dir: Henri Bismuth, 6 months) and Brussels (General and Transplant Surgery, Catholic University of Leuven, Dir: Jan Lerut, Jean Bernard Otte, Jean De Ville De Goyet, 31 months). 2006-2008, I was a practicing transplant surgeon at the University of L'Aquila, Italy. 2008-2011, I received and implemented the distinguished Marie Curie International Outgoing Fellowship, for which I spent 2 years at the Wake Forest Institute of Regenerative Medicine (Winston Salem, USA) and 1 year at the Transplant Research Immunology Group (Oxford, UK), specializing in organ bioengineering and regeneration and transplant immunology.
I have authored more than 135 research papers, review articles, and book chapters. I have just published – as editor in chief – a book on organ transplantation and regenerative medicine which is destined to set a new standard in transplant and regenerative medicine literature and to become a referral work for the future generations of specialists of both fields. I am a member of numerous transplant societies and am on the board and act as a regular reviewer for a number of relevant journals.
Marie Curie Fellow, Assistant Professor of Surgery, Department of General Surgery, Section of Transplantation, Wake Forest Baptist Health Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA
Professor of Nephrology, Director of the Department of Medicine of the Ospedali Riuniti di Bergamo (Papa Giovanni XXIII Hospital), Italy and Director of the Division of Nephrology and Dialysis of the same hospital. He also directs the Negri Bergamo Laboratories of the “Mario Negri” Institute for Pharmacological Research, a group of basic scientists and clinicians devoted to the study of human renal diseases and their corresponding animal models from the perspective of pathophysiology and therapeutic intervention. He touched major advances in many areas of nephrology. For example, his studies have led to new insights into many disorders, including the interactions between platelets and endothelium, pathophysiology of glomerular diseases and the factors that influence the progressive loss of kidney function. Work focused on improving the outlook for patients with end stage renal disease. Giuseppe Remuzzi pays tribute to the work of pioneers such as Barry Brenner, who delved deep into the processes behind glomerular function and their possible reversibility. Early work on the use of angiotensin-converting enzyme inhibitors to slow the decline of glomerular filtration rates proved dialysis was avoidable, not inevitable. Studies on immunologic mechanisms that influence the survival of transplanted organs, understanding of immunologic tolerance in the disorders that are linked to autoimmunity and finally, genetic diseases of the kidney have also been areas of investigation. Concerned by kidney donation shortages and deploring the current practice of discarding suboptimal donor kidneys, his team has shown that transplanting such kidneys in pairs is feasible and have set up an international effort to validate this approach. Giuseppe Remuzzi is investigating the kidney's ability to regenerate itself.
He authored and co-authored more than 1201 scientific articles, reviews and monographs and serves on editorial boards of numerous journals, he is member of the International Advisory Board of The Lancet and is Editorial Board member of the New England Journal of Medicine from 1995-2013. During his professional career he received the International Society of Nephrology (ISN) Jean Hamburger Award (World Congress of Nephrology (WCN) 2005, Singapore), the John P. Peters Award (American Society of Nephrology (ASN) 2007, San Francisco) and the ISN AMGEN Award (WCN 2011, Vancouver). In November 2011, he won the Third Edition of the International Award "Luis Hernando" assigned by the Iñigo Alvarez de Toledo Renal Foundation (FRIAT) in Madrid, Spain. He is, since June 2013, President of the International Society of Nephrology (ISN) for the period 2013-2015.
Professor of Nephrology, Director, Department of Medicine and Director, Division of Nephrology and Dialysis, Ospedali Riuniti di Bergamo (Papa Giovanni XXIII Hospital); Director, Negri Bergamo Laboratories, Mario Negri Institute for Pharmacological Research, Milan, Italy
Professor Williams has had 48 years experience in biomaterials, medical device and tissue engineering, working mostly at the University of Liverpool, UK where he was ultimately Professor of Biomaterials and Biomedical Engineering, Director of the UK Centre for Tissue Engineering and Senior Pro-Vice Chancellor of the University. During his career he has published over 30 books and 400 papers: his latest book, Essential Biomaterials Science, was published by Cambridge University Press in June 2014. He was Editor-in-Chief of Biomaterials, the world’s leading journal in this field between 2000 and 2014. He has received the major awards from the US, European and Indian societies of biomaterials including the Founders Award of the US Society for Biomaterials in 2007, and received the prestigious Acta Biomaterialia Gold Medal in 2012. In 1999 he was elected as a Fellow of the Royal Academy of Engineering and is a Foreign Fellow of the Indian National Academy of Engineering and a Fellow of the American Institute of Medical and Biological Engineering, all in recognition of his contributions to engineering in medicine. He was global President of the Tissue Engineering & Regenerative Medicine International Society from 2013-2015. He was a scientific advisor to several divisions of the European Commission during the 1990s and wrote several opinions on which European actions were taken. He has, over the last 20 years, given evidence in several major product liability and patent legal cases in the USA, Europe and Australia.
Professor Williams left the University of Liverpool in 2007. While retaining the title of Emeritus Professor at Liverpool, he is currently Professor and Director of International Affairs, Wake Forest Institute of Regenerative Medicine, North Carolina, USA. In addition, he is a Visiting Professor in the Christiaan Barnard Department of Cardiothoracic Surgery, Cape Town, South Africa, a Adjunct Professor at the University of Technology, Sydney, Australia, and a Guest Professor, at Tsinghua University, Beijing, and Advisory Professor at Shanghai Jiao Tong University, China. He is Visiting Chair Professor of Biomedical Materials, Taipei Medical University, Taiwan. In Cape Town, along with Professor Peter Zilla, the current Chris Barnard Professor of Surgery, he has formed a company that will produce low cost but high technology medical devices that can be used with minimally invasive procedures to treat young adults in sub-Sarah Africa, who are suffering from rheumatic heart disease but currently have no therapies available to them.
Department of Clinical Engineering, University of Liverpool, UK