Key Heterocycle Cores for Designing Multitargeting Molecules

Key Heterocycle Cores for Designing Multitargeting Molecules

1st Edition - June 11, 2018

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  • Author: Om Silakari
  • Paperback ISBN: 9780081020838
  • eBook ISBN: 9780081021057

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Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research.

Key Features

  • Emphasizes the chemical development of heterocyclic nuclei, from single to multitargeting molecules
  • Provides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multitargeting agents
  • Outlines current trends and future developments in multitarget molecule design for the treatment of various diseases


Organic, heterocyclic, computational and medicinal chemists working in both academia and industry, as well as drug discovery researchers in related fields

Table of Contents

  • 1. Multitargeting heterocycles – An improved and rational chemical probes for multifactorial diseases
    2. Benzimidazole: Journey from a single targeting to a multitargeting nucleus
    3. Acridines: A relatively lesser explored heterocycle for multifactorial diseases
    4. Flavone: An important scaffold for medicinal chemistry
    5. Thiazolidine-2,4-dione: a potential weapon for targeting multiple pathological conditions
    6. Oxindole: A nucleus enriched with multi-targeting potential against complex disorders
    7. Thiazine: A Versatile Heterocyclic Scaffold for Multifactorial Diseases
    8. Indole: As multi-target directed ligands in medicinal chemistry
    9. Triazoles: Multidimensional 5-membered nucleus for designing multitargeting agents
    10. Benzoxazolinone: A scaffold with diverse pharmacological significance

Product details

  • No. of pages: 436
  • Language: English
  • Copyright: © Elsevier 2018
  • Published: June 11, 2018
  • Imprint: Elsevier
  • Paperback ISBN: 9780081020838
  • eBook ISBN: 9780081021057

About the Author

Om Silakari

Dr. Om Silakari is an assistant professor in the Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India. He received his Ph.D. degree from Dr. Hari Singh Gour University, India and has been teaching and researching in this area for over 10 years. His research areas include computer-assisted drug designing (CADD) of new anti-inflammatory, antidiabetic and anticancer targets, and the synthesis of new lead molecules. In addition to supervising multiple M. Pharm. and PhD students, he has authored two books and published over 60 papers in international journals. Dr Silakari is an active reviewer for many international journals, has been awarded funding for several research projects, and regularly delivers talks at both national and international conferences.

Affiliations and Expertise

Assistant Professor, Department of Pharmaceutical Sciences and Drug Research, Punjab University, India

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