Ir Genes and Ia Antigens

1st Edition - January 1, 1978
Editor: Hugh Mcdevitt
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 4 2 1 - 6

Ir Genes and Ia Antigens features papers that were presented at the Third Ir Gene Workshop held in Asilomar, California, December 13-16, 1976. The book is organized into seven… Read more

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Ir Genes and Ia Antigens features papers that were presented at the Third Ir Gene Workshop held in Asilomar, California, December 13-16, 1976. The book is organized into seven parts that correspond to the seven sessions held during the workshop. The first session focused on the definition of the I-E and I-C subregions, and the mapping and cellular expression of complementing Ir genes. The second session included papers on the expression of gene products of the I region. The third session covered two major areas: (1) the biochemical characterization and primary structure of la antigens; and (2) the possible carbohydrate nature of la antigenic determinant. The studies presented in the fourth session focused on the role of I-region gene products in cellular interactions. The fifth session discussed the "recognition" functions controlled by the I region of the major histocompatibility complex (MHC). The sixth session featured papers on la-containing T cell factors. Finally, the seventh session examined the properties of T-cell antigen receptors.

Participants

Preface

Session I: Serology, Genetics, and Mapping of the / Region

Chairman's Summary: Serology, Genetics, and Mapping of the / Region

Further Serological and Genetic Characterization of the I-E and I-C Subregions

Evidence for an I-E Subregion

Evidence for the Presence of an Ia Molecule Determined by Each of the Ia-3 and Ia-5 Loci

Serological Analysis of Recombinant Strain A.TFR5

Mapping the Ir-Thy-1 Locus to the K Region of the H-2 Complex

Coupled Complementation of Ir Genes 55

Responses of Inbred Mice to Poly(Glu60Ala30Tyr10), GAT10 and Poly(Glu55Lys37Leu8)—GLLEU8—Discordant Results

Functional Complementation and Polymorphism of H-2 Linked Immune Response Genes

Gene Complementation in the T-Lymphocyte Proliferation Assay: An Analysis of the Sites of Expression of the Two Gene Products

"Interaction" MLR Stimulating Determinants Expressed on F1 Cells

Session II: Selective Expression of I Region Gene Products in Functionally Distinct Immunocompetent Cell Populations

Chairman's Summary: Selected Expression of I Region Gene Products in Functionally Distinct Immunocompetent Cell Populations

Expression of la Antigens on T Cell Leukemias and Thymocytes

T Cell Reactivity of Anti-Ia Sera

Expression of an I Region Locus in Helper T Lymphocytes

Two Loci Selectively Expressed on Functionally Different T Cells

Demonstration of T Cell Specific Ia Antigens Coded for by the I-J Subregion on Idiotypic Suppressor T Cells

Expression of la Antigens on Murine Macrophages

Subpopulations of Peritoneal Macrophages Identified with Anti-Ia Sera

The Functional Expression of la Antigens on T Lymphocytes and Macrophages in the Guinea Pig

The Association between la Antigens and Fc Receptors on Murine B Lymphocytes is Probably Ligand-Induced

Ia Antigens on FcR Positive T Lymphocytes

Session III: Chemistry of Ia Antigents

Identification of Separate I Region Products by Two-Dimensional Electrophoresis

The Guinea Pig I Region—A Structural, Genetic, and Functional Analysis

Studies of the Structure of the Human Ia-Like Antigen

Immunological Studies of Human Ia-Like Antigens

Evidence that la Antigenic Specificities Are Defined by Carbohydrate

Inability to Detect la Antigens in Mouse Sera

Antigenic Structure of the la Glycoprotein Molecules

Partial Amino Acid Sequence Analyses of Ia Molecules

Session IV: The Role of I Region Genes in Cellular Interaction

Chairman's Summary: Genetic Control of Cellular Interactions

Antigen Presentation in the T-Lymphocyte Proliferation Assay: Requirement for Genetic Identity at the Major Histocompatibility Complex

The Role of la Antigens in Macrophage-T Lymphocyte Interactions

In Vitro Responses under I Region Control

IR-IA Gene Influence on Chimeric Lymphoid Cell Interactions

Three Situations in Which Helper T Cells Fail to Collaborate with H2-Nonidentical B Cells

The Role of Inhibitory T Cells in Preventing T-B Co-operation between Histoincompatible Cells

H-2 Gene Complex Regulation of Macrophage-Lymphocyte Interactions in Antibody Responses in Vitro

On the Role of la in B-T Cell Interaction

Possible Function of H-2 Coded Cell-Surface Markers: H-2 Structures Are Receptors for Differentiation Signals

Involvement of I Region Products in T-Cell Immunity against TNP-Modified Autologous Cells 379

Session V: I Region Genes and Immunocompetent Cell Activation. New I Region Functions

Chairman's Summary: Genes and Immunocompetent Cell Activation. New I Region Functions

The Requirement of la Positive Macrophages in the Primary in Vitro Humoral Response

Determinant Selection: A Macrophage-Mediated Immune Response Gene Function

Ia Antigens on T and B Lymphocyte Subpopulations

H-2 Linked Control of the Antibody and Cellular Immune Response to Nuclease at the Level of Individual Regions of the Molecule

Inhibitory Effect of Anti-la Sera on Proliferative Responses to (H,G)-A-L and (Phe,G)-A-L

The Presence of la Antigens on the Surface of Leukemic Cells is Associated with the Immunogenicity of a Tumor Specific Transplantation Antigen

H-2 Linked Regulation of Cell-Mediated Responsiveness to an AKR Tumor Associated Antigen

Session VI: T Cell Factors Bearing Ia Determinants

Chairman's Summary: T Cell Factors Bearing la Determinants

Some Properties and Functions of Antigen Specific T Cell Factors

I-Region Products and Cell Interactions: Contribution of Non H-2 Genes to Acceptor and Factor for (T,G)-A-L

Mapping Immune Response Genes in Man Using the Antigen-Specific T Cell Factor

Role of an la-Positive Allogeneic Effect Factor in B Cell Activation

Suppressive T Cell Factor and Its Acceptor Expressed on.Different Subsets of T Cells: A Possible Amplification Loop in the Suppressor System

Expression of Ir Genes in T Cells

Properties of the Purified Immunosuppressive Factor(s) Specific for L-Glutamic Acid60-L-Alanine30-L-Tyrosine10

Specific Suppressor Extract Stimulates the Production of Suppressor T Cells

H-2 and Non H-2 Gene Control of T Cell Suppression of MLR

Session VII: The Nature of Receptors for Antigens on T Cells

Chairman's Summary: The Nature of Receptors for Antigens on T-Cells

Attempts to Evaluate the Molecular Basis of the Genetic Control of the Immune Response by Antisera Directed Against Lymphoid Cell Membrane Components

Antigen Receptors on Mouse T Lymphocytes

Idiotypic Receptors on T Lymphocytes with Specificity for Foreign MHC Alloantigens

Report on Ia Nomenclature Workshop