iPSCs - State of the Science

iPSCs - State of the Science

1st Edition - January 9, 2022

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  • Editor: Alexander Birbrair
  • eBook ISBN: 9780323856454
  • Paperback ISBN: 9780323857673

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iPSCs - State of the Science, Volume Sixteen, the latest release in the Advances in Stem Cell Biology series, is an expansive collection of information and new discoveries in the field. This volume addresses the importance of induced pluripotent stems cells and how can they be derived from different sources. It addresses advances in research in induced pluripotent stem cells from alternate sources, such as spermatogonial stem cells, ovarian tissue, cancer cells, and many other sources. It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors.

Key Features

  • Provides an overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics
  • Covers iPSCs derived from amniotic fluid, oral tissue derived iPSCs, muse cells, postmortem tissue, and much more
  • Contributed by world-renowned experts in the field


Researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation. Graduate and undergraduate students in the above fields

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Advances in Stem Cell Biology
  • Copyright
  • Dedication
  • List of contributors
  • About the editor
  • Preface
  • Chapter 1. Revealing nervous and cardiac system interactions by iPSC-Based platforms
  • Development and physiology of the cardiovascular system
  • Innervations of the heart
  • Cardiac–nervous system interactions: relevance to cardiac disorders
  • Cardiac and peripheral nervous system studies before pluripotent stem cells
  • Induced pluripotent stem cells (iPSCs)
  • New approaches to explore cardiac–nervous system interactions
  • Future perspectives
  • Limitations
  • Chapter 2. Human iPSC models of cardiac electrophysiology and arrhythmia
  • Abbreviations
  • Introduction
  • Disorders of impulse formation
  • Disorders of impulse conduction
  • Design considerations for in vitro models of arrhythmia
  • Expanded applications of human-induced pluripotent stem cell–derived cardiomyocyte models
  • Summary
  • Chapter 3. Human iPSCs for modeling of hepatobiliary development and drug discovery
  • Introduction
  • Key signals in induced pluripotent stem cell hepatobiliary differentiation
  • Modeling hepatotoxicity and liver diseases
  • The present and future of drug discovery
  • Chapter 4. The application of iPSC-derived kidney organoids and genome editing in kidney disease modeling
  • Introduction
  • Kidney
  • Kidney organoids
  • Kidney disease modeling
  • Genome editing technologies
  • Genetic kidney disease model with genome editing
  • Challenges of kidney disease modeling with genome editing
  • Chapter 5. Toward the in vitro understanding of iPSC nucleoskeletal and cytoskeletal biology, and their relevance for organoid development
  • Introduction
  • Chapter 6. Induced pluripotent stem cell models for mitochondrial disorders
  • Introduction
  • Mitochondrial genetics
  • Mitochondrial biochemistry
  • Mitochondrial diseases
  • Human stem cell models
  • Metabolic switching and cell fate decisions during early development
  • Differentiation potential and therapeutic potential for human-induced pluripotent stem cells
  • Concluding remarks
  • Chapter 7. Induced pluripotent stem cells for studying genetic autonomic disorders
  • Overview
  • Introduction
  • Autonomic nervous system disorders modeled with human pluripotent stem cells
  • Future directions and technical challenges
  • Chapter 8. Applications of iPSCs in Gaucher Disease and other rare sphingolipidoses
  • Summary
  • Introduction: from multisystemic lysosomal diseases to induced pluripotent cells
  • Overview of induced pluripotent stem cells as models of Gaucher disease
  • Overview of induced pluripotent stem cells as regenerative medicine tools
  • Future trends and directions of induced pluripotent stem cells in Gaucher disease and beyond
  • Conclusion
  • Chapter 9. Application of CRISPR/Cas system in iPSC-based disease model of hereditary deafness
  • Introduction
  • Induced pluripotent stem cells model of hereditary deafness
  • Application of CRISPR/Cas9 in induced pluripotent stem cells for hearing loss disease modeling
  • Future perspectives
  • Chapter 10. Progress and possibilities for patient-derived iPSCs and genetically engineered stem cells in cancer modeling and targeted therapies
  • Introduction
  • Cancer modeling with patient-derived induced pluripotent stem cells
  • Engineered disease trait pluripotent stem cell models
  • Applications of pluripotent stem cells
  • Conclusion
  • Index

Product details

  • No. of pages: 316
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: January 9, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780323856454
  • Paperback ISBN: 9780323857673

About the Editor

Alexander Birbrair

Dr. Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.

Affiliations and Expertise

Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil Department of Radiology, Columbia University Medical Center, Medical Center, USA

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