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Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this f… Read more
LIMITED OFFER
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration.
Biochemists and those who work in genetics, molecular biology, system biology, translational research and drug discovery
1. Early Sirtuin Research 1991-2000
2. Regulation of sirtuins by systemic NAD+ biosynthesis
3. NAD modulation - biology and therapy
4. The enzymatic activity of sirtuins
5. Molecular mechanisms of Sirtuin activation and inhibition
6. Pharmacological approaches for modulating sirtuins
7. Mitochondrial Sirtuins
8. Biological Roles and Activities for Mitochondrial Sirtuins
9. The multitasking roles of the mammalian deacetylase SIRT6
10. Chromatin and nuclear signaling: SIRT7 function in the nucleolus and beyond
11. Sirtiuns and Carcinogenesis
12. Roles for sirtuins in cardiovascular biology
13. Sirtuins in Brain Biology and Disease
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