Introduction to Molecular Biology - 1st Edition - ISBN: 9780121325503, 9780323145596

Introduction to Molecular Biology

1st Edition

Authors: S Bresler
eBook ISBN: 9780323145596
Imprint: Academic Press
Published Date: 1st January 1971
Page Count: 572
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Introduction to Molecular Biology focuses on the principles of polymer physics and chemistry and their applications to fundamental phenomena in biological sciences. It examines the structure, synthesis, and function of nucleic acids and proteins, as well as the physicochemical techniques necessary in determining the macromolecular structure, the kinetics and mechanism of enzyme action, the genetics of bacteria and their viruses, and the genetic code. It also considers the importance of precise quantitative analysis in biochemistry and biophysics, the architecture and function of biological macromolecules, and the unique mechanisms that regulate the cell's biological activity. Organized into five chapters, this book begins with an overview of proteins and their functional activity, from contractility and enzymatic catalysis to immunological activity, formation of selectively permeable membranes, and reversible binding and transport. It explains how such functions are related to molecular interactions and therefore fall within the purview of molecular biology. The book then proceeds with a discussion on the chemical structure of proteins and nucleic acids, the physicochemical techniques in measuring molecular size and shape, the mechanism of enzymatic reactions, the functions of DNA and RNA, and the mechanism of phase transition in polynucleotides. This book is intended for both biologists and non-biologists who want to be acquainted with the advances made in molecular biology, molecular genetics, and molecular biophysics during the 1950s and 1960s.

Table of Contents

Preface Introduction I. Protein Structure

1. Introduction 2. The Chemical Structure of Proteins 3. Analysis of Amino Acid Composition 4. Determination of Amino Acid Sequence in the Protein Chain 5. The Types of Macromolecular Structure 6. Synthetic Polypeptides as Model Proteins 7. Secondary Structure of Polypeptides and Proteins 8. Optical Properties of Polypeptides and Proteins 9. Theory of the Order-Disorder Transition 10. Tertiary Structure of Proteins 11. X-Ray Structure Analysis of Proteins 12. Physicochemical Techniques for Measuring Molecular Size and Shape 13. Purification and Identification of Proteins References

II. Protein Function

1. Introduction 2. Enzymatic Catalysis 3. Kinetics of Enzymatic Catalysis 4. The Mechanism of Enzymatic Reactions 5. Allosteric Regulation of Enzymatic Activity 6. Active Transport 7. The Mechanochemical Function of Proteins References

III. Nucleic Acid Structure

1. Introduction 2. Chemical Structure of the Nucleic Acids 3. Macromolecular Structure of DNA 4. Thermodynamics and the Mechanism of Phase Transition in Polynucleotides 5. Synthesis and Properties of Model Polynucleotides 6. Enzymatic Synthesis of Nucleic Acids 7. The Synthesis of Unusual Nucleic Acids 8. The Use of Isotopes in Studies on DNA Replication 9. Molecular Heterogeneity, Reversible Denaturation, and the Formation of Molecular Hybrids 10. Macromolecular Structure of RNA References

IV. DNA Function

1. Introduction 2. Bacterial Genetics 3. Mutation and Mutagenesis 4. Selection of Bacterial Mutants 5. The Luria-Delbruck Fluctuation Experiment 6. Sex in Bacteria; Conjugation 7. Replication of the Bacterial-Chromosome during Vegetative Growth and during Conjugation 8. Mechanism of Recombination 9. Genetic Mappi


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© Academic Press 1971
Academic Press
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About the Author

S Bresler

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