Introduction to Enzymology

Introduction to Enzymology

1st Edition - January 1, 1957

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  • Author: Alan H. Mehler
  • eBook ISBN: 9781483258478

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Introduction to Enzymology focuses on the processes, methodologies, reactions, and approaches involved in enzyme chemistry. The book first offers information on the hydrolysis of peptides and proteins and fermentation and oxidation of major metabolic fuels. Discussions focus on oxidation of fatty acids, alternative pathways of carbohydrate metabolism, Krebs citric acid cycle, free energy and the concept of bond energy, pyruvate oxidation and acetyl coenzyme A formation, and glycolysis. The text then elaborates on the transfer of oxygen, hydrogen, and electrons and sugars and sugar derivatives. The publication takes a look at polynucleotides and their components, amino acids, and acids and acid derivatives. Topics include carbonic anhydrase, mechanism of action of pyridoxal phosphate enzymes, aromatic ring biosynthesis and metabolism of phenylalanine and tyrosine, metabolism of sulfur-containing amino acids, and oxidation of amino acids. The book is a valuable reference for chemists and researchers interested in enzymology.

Table of Contents

  • Preface

    I. Introduction

    II. Hydrolysis of Peptides and Proteins

    III. Fermentation and Oxidation of Major Metabolic Fuels


    Pyruvate Oxidation and Acetyl Coenzyme A Formation

    Free Energy and the Concept of Bond Energy

    Reactions of Coenzyme A

    The Krebs Citric Acid Cycle

    Alternative Pathways of Carbohydrate Metabolism

    Oxidation of Fatty Acids

    IV. Biological Oxidation: Tranfer of Oxygen, Hydrogen, and Electrons

    Pyridine Nucleotides

    Oxidation-Reduction Potentials



    The Hydroperoxidases: Catalase and Peroxidase

    Oxidases and Oxygenases

    V. Sugars and Sugar Derivatives


    Reactions of Uridine Nucleotides

    VI. Polynucleotides and their Components

    Nucleic Acids

    Purines and Pyrimidines

    VII. Amino Acids

    Amino Acid Decarboxylases


    Oxidation of Amino Acids

    Glutamic Acid and Amino Acids Derived from It

    Aspartic Acid, Threonine, and Lysine

    The Urea Cycle

    β-Hydroxy-α-amino Acids

    Metabolism of Sulfur-Containing Amino Acids


    Aromatic Ring Biosynthesis and Metabolism of Phenylalanine and Tyrosine


    Mechanism of Action of Pyridoxal Phosphate Enzymes

    Metabolism of Amines

    VIII. Acids and Acid Derivatives


    Carbonic Anhydrase

    IX. Organization of Structure and Function

    Integration of Biochemical Reactions

    Adaptive Enzymes and the Synthesis of Proteins

    Appendix: Abbreviations

    Subject Index

Product details

  • No. of pages: 439
  • Language: English
  • Copyright: © Academic Press 1957
  • Published: January 1, 1957
  • Imprint: Academic Press
  • eBook ISBN: 9781483258478

About the Author

Alan H. Mehler

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