International Review of Connective Tissue Research - 1st Edition - ISBN: 9780123637086, 9781483191706

International Review of Connective Tissue Research

1st Edition

Volume 8

Editors: David A. Hall D. S. Jackson
eBook ISBN: 9781483191706
Imprint: Academic Press
Published Date: 28th August 1979
Page Count: 318
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Description

International Review of Connective Tissue Research, Volume 8, provides an overview of the state of knowledge in connective tissue research. The details of the structure of collagen and its biosynthesis are now well established, and attention has focused on the finer details of the biochemical mechanisms involved. The knowledge achieved so far is also being applied to studies of various physiological, developmental, and pathological mechanisms involving the connective tissues. These trends are reflected in the subject covered by this volume.

The enzymes involved in the posttranslation modifications of collagen are being intensively investigated. The book deals with three of these: lysyl oxidase, the enzyme involved in the first stage of cross-link formation; and the two glycosyl transferases involved in the glycosylation of hydroxylysome residues. New collagen types are reviewed together with recent work on collagen messenger RNA. Both of these topics are important to the understanding of the control of collagen biosynthesis. The involvement of connective tissues in physiological and pathological processes is discussed in three areas. These are interaction of collagen with platelets in hemostasis; the biosynthesis of connective tissue components by smooth muscle cells; and biochemical research on the intervertebral disc, the disease of which is behind the majority of back pain problems.

Table of Contents


Contributors


Preface


Contents of Previous Volumes


Collagen-Platelet Interaction


I. Introduction


II. Types of Collagens and Their Reactivities with Platelets


III. Structural Features of Collagen in Relation to Interaction with Platelets


IV. Role of Carbohydrate Residues of Collagen


V. Binding of Collagen to Platelets


VI. Membrane-Associated Reactions in Platelets


VII. Conclusions


References


Collagen Glycosyltransferases


I. Introduction


II. Structure and Occurrence of the Hydroxylysyl-Linked Carbohydrate Units


III. Assay of Hydroxylysyl-Linked Carbohydrate Units and Hydroxylysyl Glycosyltransferase Activities


IV. Purification and Molecular Properties of the Hydroxylysyl Glycosyltransferases


V. Catalytic Properties of the Hydroxylysyl Glycosyltransferases


VI. Intracellular Sites of Hydroxylysyl Glycosylations and the Relationship of These Reactions to Other Intracellular Events of Collagen Biosynthesis


VII. Regulation of Hydroxylysyl Glycosyltransferase Activities and Extent of the Glycosylations


VIII. Relation of Galactosylhydroxylysyl Glucosyltransferase to Platelet: Collagen Aggregation


IX. Presence of Carbohydrate Units in the Peptide Extensions of Procollagen and Biosynthesis of These Units


X. Summary


References


Lysyl Oxidase


I. Introduction


II. Historical Considerations


III. Biochemical Properties


IV. Biology of Lysyl Oxidase


V. Studies with Model Systems of Collagen Cross-Linking


VI. Future Research


VII. Summary


References


Synthesis of Connective Tissue Macromolecules by Smooth Muscle


I. Introduction


II. El

Details

No. of pages:
318
Language:
English
Copyright:
© Academic Press 1979
Published:
Imprint:
Academic Press
eBook ISBN:
9781483191706

About the Editor

David A. Hall

D. S. Jackson

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