International Review of Cell and Molecular Biology - 1st Edition - ISBN: 9780128048047, 9780128052204

International Review of Cell and Molecular Biology, Volume 327

1st Edition

Serial Editors: Kwang Jeon Lorenzo Galluzzi
eBook ISBN: 9780128052204
Hardcover ISBN: 9780128048047
Imprint: Academic Press
Published Date: 29th September 2016
Page Count: 440
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Table of Contents

  • Contributors
    • Dedication
      • Chapter One: Sensing the Environment Through Sestrins: Implications for Cellular Metabolism
        • Abstract
        • Abbreviations
        • 1. Introduction
        • 2. Regulation and Function of Sestrins
        • 3. Sestrins are Sensors of Nutrient Availability and are Involved in Regulation of Metabolism
        • 4. Conclusions and Perspectives
        • Acknowledgments
      • Chapter Two: Metabolic Regulation of Apoptosis in Cancer
        • Abstract
        • 1. Introduction
        • 2. Overview of Apoptosis Pathways
        • 3. Regulation of Apoptosis Through Glycolytic Pathway
        • 4. p53 and Glucose Metabolism
        • 5. Regulation of Apoptosis by Lipid Metabolism
        • 6. Concluding Remarks
        • Acknowledgments
      • Chapter Three: A Mechanistic Approach to the Development of Gene Therapy for Chronic Pain
        • Abstract
        • 1. Introduction
        • 2. Basics of Gene Therapy
        • 3. Physiological Mechanisms of Nociception/Pain
        • 4. Chronic Neuropathic Pain
        • 5. Chronic Nociceptive or Inflammatory Pain
        • 6. Chronic Mixed Pain (Cancer), Opioid Analgesia, and Gene Therapy
        • 7. Conclusions
        • Acknowledgments
      • Chapter Four: Roles and Regulation of Epithelial Splicing Regulatory Proteins 1 and 2 in Epithelial–Mesenchymal Transition
        • Abstract
        • 1. Introduction
        • 2. Epithelial–Mesenchymal Transition Program
        • 3. Alternative Splicing in EMT
        • 4. ESRPs as Regulators of EMT
        • 5. Regulation of ESRP Expression and Function
        • 6. Linking ESRPs to Carcinogenesis
        • 7. Concluding Remarks
      • Chapter Five: Orchestrating Lymphocyte Polarity in Cognate Immune Cell–Cell Interactions
        • Abstract
        • 1. Introduction
        • 2. Membrane Microdomains and Nanoclusters Orchestrate Cell–Cell Contacts
        • 3. Centrosome as Organelle-Organizing Center
        • 4. Endoplasmic Reticulum and Golgi Apparatus
        • 5. Multivesicular Bodies in Secretion, Recycling, and Renewal of Immune Synapse Components
        • 6. Lysosomes and Autophagy: More Than Degradation
        • 7. Mitochondria: Powering Immune Synapse
        • 8. Lytic Granules: Polarizing Killing Machinery
        • 9. Asymmetric Cell Division: Versus Clonal Expansion
        • 10. Concluding Remarks
        • Acknowledgments
      • Chapter Six: The Process of Cornification Evolved From the Initial Keratinization in the Epidermis and Epidermal Derivatives of Vertebrates: A New Synthesis and the Case of Sauropsids
        • Abstract
        • 1. Introduction
        • 2. Keratinization and Cornification are Continuous but not Equivalent Process
        • 3. Anamniote Epidermis Keratinizes While Cornification Occurs in few Body Regions
        • 4. Formation of the Corneous Layer in Amniotes
        • 5. Increase of Protein Types in Amniote Epidermis Compared to Anamniotes
        • 6. Alpha and Beta-Keratinization Indicate Prevalence of Corneous Proteins Containing Alpha-Helix or Beta-Sheets, not of Keratins
        • 7. Differences Between IF-Alpha/Beta-Keratins and Sauropsid Beta-Keratins Indicate the Latter are Corneous Beta-Proteins
        • 8. The Process of Cornification in Sauropsids
        • 9. Evolution of the Process of Cornification in the Epidermis and Skin Appendages: A New Synthesis
        • 10. Concluding Remarks and Future Directions
        • Acknowledgements
      • Chapter Seven: The Calcium-Sensing Receptor in Health and Disease
        • Abstract
        • Abbreviations
        • 1. Structure and Physiological Functions of the CaSR
        • 2. Monitoring CaSR Activity in Living Cells
        • 3. CaSR in Endocrine Pathology
        • 4. CaSR in Cardiovascular Physiopathology
        • 5. CaSR in Asthma
        • 6. CaSR in Alzheimer's Disease
        • 7. CaSR in Cancer
        • Acknowledgments
      • Chapter Eight: Molecular Interactions Between Flowering Time and Abiotic Stress Pathways
        • Abstract
        • 1. Introduction
        • 2. Developmental and Seasonal Control of Flowering Time
        • 3. Key Molecular Regulators of Flowering Time
        • 4. Abiotic Stresses Affecting Flowering Time
        • 5. Stress-Signal Integration by Major Flowering Time Regulators
        • 6. Role of GI in Influencing Flowering Time and Circadian Clock Components
        • 7. Conclusions
        • Acknowledgments
      • Index


        International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology, and includes articles that address the structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth.

        The series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics as authored by prominent cell and molecular biologists.

        Key Features

        • Provides comprehensive reviews and current advances
        • Presents a wide range of perspectives on specific subjects
        • Valuable reference material for advanced undergraduates, graduate students, and professional scientists


        Cell biologists, molecular biologists, developmental biologists, and physiologists (organ level): biomedical scientists and biochemists studying cell-cell interactions and cell variation; and evolution students and researchers


        No. of pages:
        © Academic Press 2016
        Academic Press
        eBook ISBN:
        Hardcover ISBN:

        Ratings and Reviews

        About the Serial Editors

        Kwang Jeon Serial Editor

        Kwang Jeon received his Ph.D. in cell physiology at King’s College, University of London, UK, in 1964 and taught at SUNY Buffalo and University of Tennessee. His research was concerned with the biogenesis and function of cell components in two major areas: Integration of intracellular symbionts into host cells leading to the acquisition of new cell components and cell variation; Membrane-protein recycling during endo- and exocytosis.

        Affiliations and Expertise

        University of Tennessee, Knoxville, TN, USA

        Lorenzo Galluzzi Serial Editor

        Lorenzo Galluzzi received his Ph.D. in 2008 from the University of Paris Sud/Paris XI (France), and now works as a research manager in the laboratory of Guido Kroemer. He is particularly fascinated by several aspects of mitochondrial cell death, autophagy, cancer cell metabolism and tumour immunology. He has published more than 270 articles in peer-reviewed scientific journals, and is currently the 6th and youngest of the 30 most-cited European cell biologists (relative to the period 2007-2013).

        Affiliations and Expertise

        Department of Radiation Oncology, Weill Cornell Medical College, NY, USA