COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
International Review of Cell and Molecular Biology - 1st Edition - ISBN: 9780128048047, 9780128052204

International Review of Cell and Molecular Biology, Volume 327

1st Edition

Serial Editors: Kwang Jeon Lorenzo Galluzzi
Hardcover ISBN: 9780128048047
eBook ISBN: 9780128052204
Imprint: Academic Press
Published Date: 29th September 2016
Page Count: 440
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

Chapter One: Sensing the Environment Through Sestrins: Implications for Cellular Metabolism

  • Abstract
  • Abbreviations
  • 1. Introduction
  • 2. Regulation and Function of Sestrins
  • 3. Sestrins are Sensors of Nutrient Availability and are Involved in Regulation of Metabolism
  • 4. Conclusions and Perspectives
  • Acknowledgments

Chapter Two: Metabolic Regulation of Apoptosis in Cancer

  • Abstract
  • 1. Introduction
  • 2. Overview of Apoptosis Pathways
  • 3. Regulation of Apoptosis Through Glycolytic Pathway
  • 4. p53 and Glucose Metabolism
  • 5. Regulation of Apoptosis by Lipid Metabolism
  • 6. Concluding Remarks
  • Acknowledgments

Chapter Three: A Mechanistic Approach to the Development of Gene Therapy for Chronic Pain

  • Abstract
  • 1. Introduction
  • 2. Basics of Gene Therapy
  • 3. Physiological Mechanisms of Nociception/Pain
  • 4. Chronic Neuropathic Pain
  • 5. Chronic Nociceptive or Inflammatory Pain
  • 6. Chronic Mixed Pain (Cancer), Opioid Analgesia, and Gene Therapy
  • 7. Conclusions
  • Acknowledgments

Chapter Four: Roles and Regulation of Epithelial Splicing Regulatory Proteins 1 and 2 in Epithelial–Mesenchymal Transition

  • Abstract
  • 1. Introduction
  • 2. Epithelial–Mesenchymal Transition Program
  • 3. Alternative Splicing in EMT
  • 4. ESRPs as Regulators of EMT
  • 5. Regulation of ESRP Expression and Function
  • 6. Linking ESRPs to Carcinogenesis
  • 7. Concluding Remarks

Chapter Five: Orchestrating Lymphocyte Polarity in Cognate Immune Cell–Cell Interactions

  • Abstract
  • 1. Introduction
  • 2. Membrane Microdomains and Nanoclusters Orchestrate Cell–Cell Contacts
  • 3. Centrosome as Organelle-Organizing Center
  • 4. Endoplasmic Reticulum and Golgi Apparatus
  • 5. Multivesicular Bodies in Secretion, Recycling, and Renewal of Immune Synapse Components
  • 6. Lysosomes and Autophagy: More Than Degradation
  • 7. Mitochondria: Powering Immune Synapse
  • 8. Lytic Granules: Polarizing Killing Machinery
  • 9. Asymmetric Cell Division: Versus Clonal Expansion
  • 10. Concluding Remarks
  • Acknowledgments

Chapter Six: The Process of Cornification Evolved From the Initial Keratinization in the Epidermis and Epidermal Derivatives of Vertebrates: A New Synthesis and the Case of Sauropsids

  • Abstract
  • 1. Introduction
  • 2. Keratinization and Cornification are Continuous but not Equivalent Process
  • 3. Anamniote Epidermis Keratinizes While Cornification Occurs in few Body Regions
  • 4. Formation of the Corneous Layer in Amniotes
  • 5. Increase of Protein Types in Amniote Epidermis Compared to Anamniotes
  • 6. Alpha and Beta-Keratinization Indicate Prevalence of Corneous Proteins Containing Alpha-Helix or Beta-Sheets, not of Keratins
  • 7. Differences Between IF-Alpha/Beta-Keratins and Sauropsid Beta-Keratins Indicate the Latter are Corneous Beta-Proteins
  • 8. The Process of Cornification in Sauropsids
  • 9. Evolution of the Process of Cornification in the Epidermis and Skin Appendages: A New Synthesis
  • 10. Concluding Remarks and Future Directions
  • Acknowledgements

Chapter Seven: The Calcium-Sensing Receptor in Health and Disease

  • Abstract
  • Abbreviations
  • 1. Structure and Physiological Functions of the CaSR
  • 2. Monitoring CaSR Activity in Living Cells
  • 3. CaSR in Endocrine Pathology
  • 4. CaSR in Cardiovascular Physiopathology
  • 5. CaSR in Asthma
  • 6. CaSR in Alzheimer's Disease
  • 7. CaSR in Cancer
  • Acknowledgments

Chapter Eight: Molecular Interactions Between Flowering Time and Abiotic Stress Pathways

  • Abstract
  • 1. Introduction
  • 2. Developmental and Seasonal Control of Flowering Time
  • 3. Key Molecular Regulators of Flowering Time
  • 4. Abiotic Stresses Affecting Flowering Time
  • 5. Stress-Signal Integration by Major Flowering Time Regulators
  • 6. Role of GI in Influencing Flowering Time and Circadian Clock Components
  • 7. Conclusions
  • Acknowledgments


International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology, and includes articles that address the structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth.

The series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics as authored by prominent cell and molecular biologists.

Key Features

  • Provides comprehensive reviews and current advances
  • Presents a wide range of perspectives on specific subjects
  • Valuable reference material for advanced undergraduates, graduate students, and professional scientists


Cell biologists, molecular biologists, developmental biologists, and physiologists (organ level): biomedical scientists and biochemists studying cell-cell interactions and cell variation; and evolution students and researchers


No. of pages:
© Academic Press 2016
29th September 2016
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Serial Editors

Kwang Jeon

Kwang Jeon

Kwang Jeon received his Ph.D. in cell physiology at King’s College, University of London, UK, in 1964 and taught at SUNY Buffalo and University of Tennessee. His research was concerned with the biogenesis and function of cell components in two major areas: Integration of intracellular symbionts into host cells leading to the acquisition of new cell components and cell variation; Membrane-protein recycling during endo- and exocytosis.

Affiliations and Expertise

University of Tennessee, Knoxville, TN, USA

Lorenzo Galluzzi

Lorenzo Galluzzi

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.

Affiliations and Expertise

Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA