International Review of Cell and Molecular Biology

International Review of Cell and Molecular Biology

Contributors

Chapter One. Control of Actin Dynamics by Allosteric Regulation of Actin Binding Proteins

Abstract

1. Introduction

2. Vinculin

3. Ezrin, Radixin, and Moesin

4. N-WASP

5. Zyxin

6. Summary

References

Chapter Two. Dynamics and Regulation of Epithelial Adherens Junctions: Recent Discoveries and Controversies

Abstract

1. Introduction

2. Molecular Composition of Epithelial AJs

3. Regulation of AJs by Vesicle Trafficking

4. Regulation of AJs by the Cytoskeleton

5. AJs and Human Diseases

6. Conclusions

Acknowledgments

References

Chapter Three. Regulation of Cilium Length and Intraflagellar Transport

Abstract

1. Introduction

2. Cilia and Intraflagellar Transport

3. Cilium Assembly and Disassembly

4. Regulation of Cilium Length and IFT

5. Conclusions and Perspectives

References

Chapter Four. Cellular and Molecular Biology of Airway Mucins

Abstract

1. Introduction

2. Mucus, Mucins, and COPD

3. Structure of Airway Mucins

4. Mucin Secretion

5. Physiologic Role of MUC1 Mucin in the Airways

6. Concluding Remarks

Acknowledgments

References

Chapter Five. Extracellular Hsp90 (eHsp90) as the Actual Target in Clinical Trials: Intentionally or Unintentionally

Abstract

1. Introduction

2. Hsp90α versus Hsp90β

3. eHsp90, but Not Intracellular Hsp90 Chaperone: Difference in Physiology and Pathophysiology

4. eHsp90 as an Unconventional Promotility Factor

5. eHsp90 in Blood Circulation in Normal and Cancer Patients

6. Hsp90 versus eHsp90: Related but not the Same Molecule Any More

7. eHsp90: Actual Target from Day One?

8. Conclusions and Perspectives

Acknowledgments

References

Chapter Six. New Insights into the Mechanism for Chromosome Alignment in Metaphase

Abstract

1. Introduction

2. Initial Spindle Microtubule Capture by Kinetochore

3. Conversion from Lateral Binding to End-on Attachment

4. Stable End-on Kinetochore-Microtubule Attachment

5. Chromosome Congression and Oscillation at Metaphase Plate

6. Kinetochore-Microtubule Attachment Error Correction

7. Conclusions

Acknowledgments

References

Chapter Seven. New Insights into the Developmental Mechanisms of Coronary Vessels and Epicardium

Abstract

1. Introduction

2. Developmental Anatomy of Coronary Vessels

3. Signals Regulating PE Formation

4. Epicardium Formation

5. Epicardial EMT

6. Formation of Subepicardial Coronary Plexus

7. Arterial and Venous Differentiation during Coronary Vessel Development

8. Vascular Wall Development

9. Coronary Vessel Pathology

10. Concluding Remarks

Acknowledgments

References

Chapter Eight. New Insights into Roles of Tubulobulbar Complexes in Sperm Release and Turnover of Blood-Testis Barrier

Abstract

1. Introduction

2. Tubulobulbar Complex Structure

3. Functions

4. Regulation

5. Experimental Models

6. Conclusion and Future Directions

References

Chapter Nine. Role of microRNA-138 as a Potential Tumor Suppressor in Head and Neck Squamous Cell Carcinoma

Abstract

1. Introduction

2. Background

3. MicroRNA-138 Deregulation in HNSCC and its Functional Relevance

4. Biological Processes Regulated by microRNA-138

5. Conclusion

Acknowledgments

References

Index