Insecticides

Insecticides

Action and Metabolism

1st Edition - January 1, 1967

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  • Author: R. D. O'Brien
  • eBook ISBN: 9781483270685

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Description

Insecticides: Action and Metabolism provides a comprehensive review of the action of insecticides and a survey of their metabolism. This book discusses the toxicology of insecticides. Organized into 17 chapters, this book begins with an overview of the mechanisms whereby toxicants exert their effects. This text then discusses the insecticidal action of organophosphates, which is described as the toxic organic compounds containing phosphorus. Other chapters consider the mode of action of organophosphates by inhibiting cholinesterase with consequent disruption of nervous activity caused by accumulation of acetylcholine at nerve endings. This book discusses as well the erratic patterns of selective toxicity to insects of the carbamates. The final chapter deals with the real hazard to human health as well as the effects upon wild life of insecticides and chlorinated pesticides. This book is a valuable resource for organic and agricultural chemists, as well as biologists, agriculturists, neurophysiologists, environmental scientists, and research workers.

Table of Contents


  • Preface

    Chapter 1 Introduction

    Toxicology

    Modes of Killing

    The Causal Chain Leading to Death

    Background Chemistry

    Electronic Interpretations

    Background Neurobiology

    References

    Chapter 2 Physical Toxicants

    Indifferent Narcotics

    The Cutoff Point

    The ρ-σ-π Analysis

    References

    Chapter 3 Organophosphates: Chemistry and Inhibitory Activity

    Nomenclature

    Nonenzymic Reactions

    Reaction with Cholinesterase

    References

    Chapter 4 Organophosphates: Action, Therapy, and Metabolism

    Mode of Action

    Therapy

    Metabolism

    References

    Chapter 5 Carbamates

    Toxicity

    Mode of Action

    Mechanism of Cholinesterase Inhibition

    Metabolism

    Synergism

    References

    Chapter 6 DDT and Related Compounds

    Structure and Chemistry

    DDT Analogs

    Toxicity

    Mechanism of Action

    Metabolism of DDT

    References

    Chapter 7 Cyclodienes

    Toxicity

    Mode of Action

    Metabolism

    References

    Chapter 8 Nicotinoids

    Toxicity

    Mechanism of Action

    Metabolism

    References

    Chapter 9 Rotenoids

    Mode of Action

    Metabolism

    References

    Chapter 10 Pyrethroids

    Mode of Action

    Metabolism

    References

    Chapter 11 Fluorine Compounds

    Fluoro-organics

    Sodium Fluoride

    References

    Chapter 12 Lindane and Other Hexachlorocyclohexanes

    Toxicity

    Mode of Action

    Metabolism

    References

    Chapter 13 Various Compounds

    Arsenicals

    Silica Aerogels

    Ryanodine

    DNOC and Dinex

    References

    Chapter 14 Synergism, Antagonism, and Other Interactions

    Inductive Effects

    Noninductive Effects

    References

    Chapter 15 Resistance

    DDT Resistance

    Cyclodiene Resistance

    Lindane Resistance

    Organophosphate Resistance

    Carbamate Resistance

    Conclusion

    References

    Chapter 16 Selectivity; Penetration

    General Principles

    Contact of Toxicant and Organism

    Penetration into the Organism

    Metabolism

    Penetration to the Target

    Disposal (Storage and Excretion)

    Attack upon the Target

    Consequences of a Successful Attack upon the Target

    References

    Chapter 17 Insecticides and Environmental Health

    Problems of Human Health

    Effects upon Wildlife

    References

    Author Index

    Subject Index




Product details

  • No. of pages: 344
  • Language: English
  • Copyright: © Academic Press 1967
  • Published: January 1, 1967
  • Imprint: Academic Press
  • eBook ISBN: 9781483270685

About the Author

R. D. O'Brien

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