Inorganic Controlled Release Technology

Inorganic Controlled Release Technology

Materials and Concepts for Advanced Drug Formulation

1st Edition - August 24, 2015

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  • Authors: Xiang Zhang, Mark Cresswell
  • Hardcover ISBN: 9780080999913
  • eBook ISBN: 9780081000069

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Inorganic Controlled Release Technology: Materials and Concepts for Advanced Drug Formulation provides a practical guide to the use and applications of inorganic controlled release technology (iCRT) for drug delivery and other healthcare applications, focusing on newly developed inorganic materials such as bioresorbable glasses and bioceramics. The use of these materials is introduced for a wide range of applications that cover inorganic drug delivery systems for new drug development and the reformulation of existing drugs. The book describes basic concepts, principles, and industrial practices by discussing materials chemistry, physics, nano/microstructure, formulation, materials processing, and case studies, as well as the evaluation and characterization of iCRT systems commonly investigated during industrial R&D.

Key Features

  • Provides the first book on inorganic controlled release technology (iCRT), covering key aspects from chemistry, physics, synthetic methods, formulation design, characterization and evaluation
  • Includes several industry-related case studies to provide practical guidance on how to use iCRT as an alternative to organic polymers systems for both future drug developments and other active ingredient applications
  • Demonstrates how iCRT offers an unmet business need for improved, controlled release of actives versus traditional CRT systems, which are known to have difficulty with the controlled delivery of both poorly and highly water soluble drug compounds


Pharmaceutical scientists, formulation specialists, engineers, doctors, clinicians, managers and later year undergraduates and postgraduates working in the pharmaceutical, cosmetic, veterinary and agricultural sectors.

Table of Contents

    • About the Author
    • Preface
    • Acknowledgments
    • Key Features
    • Chapter 1: Materials for Inorganic Controlled Release Technology
      • Abstract
      • 1.1 Introduction
      • 1.2 Comparison between Organic and Inorganic CRT
      • 1.3 Materials Chemistry and Processing Technology
      • 1.4 Materials Physics and Drug-Loaded Micro/Nanostructure
    • Chapter 2: Materials Fundamentals of Drug Controlled Release
      • Abstract
      • 2.1 Introduction of Materials Nanostructure
      • 2.2 API Distribution Within Inorganic Matrices
      • 2.3 Basic Understanding of Potential Molecular Interactions
      • 2.4 Theory and Practical Modelling of Drug Controlled Release Kinetics
    • Chapter 3: Materials Characterization of Inorganic Controlled Release
      • Abstract
      • 3.1 Introduction
      • 3.2 Chemical Analysis
      • 3.3 Physical Property Analysis
      • 3.4 Microscopy
      • 3.5 Technology for Evaluation of API and Inorganic CRT Carrying System
    • Chapter 4: Silica-Based Amorphous Drug Delivery Systems
      • Abstract
      • 4.1 Introduction
      • 4.2 Sol-Gel Chemistry and Processing
      • 4.3 Ordered Mesoporous Silica
      • 4.4 Non-Ordered Porous Silica for Controlled Release
      • 4.5 Porous Silica for Improved Efficacy and Tolerability of Topically Administered Active Compounds
    • Chapter 5: Mesoporous Bioactive Glass-Based Controlled Release Systems
      • Abstract
      • 5.1 Introduction
      • 5.2 General Synthesis Methods for Mesoporous Bioactive Glasses
      • 5.3 Mesoporous Glass-Based 3D Scaffold Structures
      • 5.4 The Role of MBG Surface Functionalization for Controlling Active Release
      • 5.5 Case Studies
      • 5.6 Conclusions and Future Context
    • Chapter 6: Calcium Phosphate Materials for Controlled Release Systems
      • Abstract
      • 6.1 Calcium Phosphate Materials and Their Properties
      • 6.2 Calcium Phosphate Cements
      • 6.3 Calcium Phosphate Foams for Drug Delivery
      • 6.4 Drug Release from Calcium Phosphate Coatings
    • Chapter 7: Alternative Inorganic Systems for Controlled Release Applications
      • Abstract
      • 7.1 Introduction
      • 7.2 Clays
      • 7.3 Alternative Mesoporous Inorganic CRT Materials
      • 7.4 Nanoparticle Delivery Systems
    • Chapter 8: Future Development of iCRT
      • Abstract
      • 8.1 Overview
      • 8.2 Design and Development of Inorganic CRT Systems
      • 8.3 Regulation and Relevant Issues
      • 8.4 Summary
    • Index

Product details

  • No. of pages: 264
  • Language: English
  • Copyright: © Butterworth-Heinemann 2015
  • Published: August 24, 2015
  • Imprint: Butterworth-Heinemann
  • Hardcover ISBN: 9780080999913
  • eBook ISBN: 9780081000069

About the Authors

Xiang Zhang

Dr Xiang Zhang, the Royal Society Industry Fellow at University of Cambridge, is a materials scientist and one of the leading biomaterials and medical devices experts in the world with 33 years combined experience, 17 years in academia and 16 years in industry. He places particular emphasis on carrying out fundamental but applied research as he believes that this in depth fundamental understanding of specific scientific issues is the key to the design and development of successful medical products for industry to benefit society. Dr Zhang undertook his PhD and postdoctoral research at Cranfield University where he studied materials physics and nano-fracture mechanics of organic and inorganic hybrid materials and developed new materials for ICI the largest chemical manufacturer in Britain at that time. He was awarded an industrial fellowship at the University of Cambridge in 1995. His industry experience was gained at Abbott in 1999, where, as Principal Scientist, his work covered almost all aspects of medical materials and devices from R&D and manufacturing. Further industrial experiences were gained with Cambridge NanoTech and Lucideon as Consultant Director and Principal Consultant respectively, working for worldwide clients to provide materials solutions for pharmaceutical companies and research institutes.

Affiliations and Expertise

Royal Society Industry Fellow, University of Cambridge and Principal Consultant, Lucideon, Stoke-on-Trent, UK

Mark Cresswell

Dr Mark Cresswell is a Senior Scientist at Lucideon and has been instrumental in developing Lucideon’s iCRT (inorganic Controlled Release Technologies) research programme. His research covers a wide spectrum of the chemical sciences which has enabled him to become an expert in his field. In addition to the inorganic chemistry discussed in this iCRT book, he has good experience in organic synthetic chemistry. This includes the development of new synthetic routes for solution-phase-based peptide synthesis and the use of a diastereoselective Pictet-Spengler reaction to generate optically pure tetrahydro-β-carbolines. This methodology was then applied to the asymmetric synthesis of medicinally useful indole alkaloids. Dr Cresswell was awarded an MChem in Chemistry with Medicinal Chemistry from the University of Manchester and his PhD from Keele University. At Lucideon Dr Cresswell is responsible for the development of innovative new materials for healthcare applications with a focus on the application of novel inorganic-based drug delivery systems. Particular research interests are the use of novel sol-gel processing to prepare silicate and phosphate derived porous drug delivery systems and the design of new glasses with controlled dissolution properties.

Affiliations and Expertise

Development Scientist, Healthcare, Lucideon, Stoke-on-Trent, UK

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