Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells

Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells provides a complete overview of this important research area that is perfect for both newcomers and expert researchers in the field. Through concise chapters written and edited by esteemed experts, this book brings together a comprehensive treatment of the area previously only available through scattered, lengthy review articles in the literature. Advanced topics of research are covered, with particular focus on recent advances in the biological applications of transition metal complexes, including inorganic medicine, enzyme inhibitors, antiparasital agents, and biological imaging reagents.

• Geared toward researchers and students who seek an introductory overview of the field, as well as researchers working in advanced areas
• Focuses on the interactions of inorganic and organometallic transition metal complexes with biological molecules and live cells
• Foscuses on the fundamentals and their potential therapeutic and diagnostic applications
• Covers recent biological applications of transition metal complexes, such as anticancer drugs, enzyme inhibitors, bioconjugation agents, chemical biology tools, and bioimaging reagents

Inorganic chemistry, medicinal chemistry, and drug development researchers; secondarily advanced chemistry and biology students

Chapter One. Luminescent Zinc Complexes as Bioprobes for Imaging Molecular Events in Live Cells

• 1. Introduction
• 2. General Considerations
• 3. Luminescent Zinc Complexes as Bioprobes
• 4. Conclusion and Outlook

Chapter Two. Cellular Uptake and Sensing Capability of Transition Metal Peptide Conjugates

• 1. Introduction
• 2. Transition Metal Complexes for Cell Imaging and Sensing
• 3. Cell-Penetrating Peptides
• 4. Mechanism of CPP Uptake
• 5. CPP Modified Transition Metal Luminophores for Sensing and Imaging
• 6. Signal Peptide-Modified Transition Metal Luminophores
• 7. Conclusions and Future Outlook

Chapter Three. Luminescent Rhenium(I) and Iridium(III) Complexes for Intracellular Labeling, Sensing, and Photodynamic Therapy Applications

• 1. Introduction
• 2. Intracellular Labels
• 3. Intracellular Sensors
• 4. Ratiometric Sensors
• 5. Photodynamic Therapy
• 6. Conclusion

Chapter Four. Organoruthenium(II)-Arene Complexes: Structural Building Blocks for Anticancer Drug Discovery

• 1. Introduction
• 2. Accessing the Ruthenium(II)-Arene Scaffold
• 3. Ru(II)-Arene Drug Candidates Under Investigation
• 4. Cytotoxic Ru(II)-Arene Complexes via Classical Approaches
• 5. Nonclassical Ru(II)-Arene Complexes by Rational Design
• 6. Nonclassical Ru(II)-Arene Complexes From Classical Approaches
• 7. Conclusion

Chapter Five. Medicinal Chemistry of Metal N-Heterocyclic Carbene (NHC) Complexes

• 1. Introduction
• 2. Metal NHC Complexes With Classical N–C–N Carbene Ligands
• 3. Metal NHC Complexes With “Nonclassical” NHC Ligands and Heterobimetallic Metal NHC Complexes
• 4. Metal NHC Complexes With Biologically Active, Biogenic, or Targeting Ligands
• 5. Conclusions

Chapter Six. Metal Complexes as Delivery Systems for CO, NO, and H2S to Explore the Signaling Network of Small-Molecule Messengers

• 1. Introduction
• 2. Enzymatic Generation of CO, NO, and H2S
• 3. Delivery Systems for CO, NO, and H2S
• 4. Molecular Probes for Small-Molecule Messengers
• 5. Cellular Target Structures of CO, NO, and H2S
• 6. Summary

Chapter Seven. Antimicrobial Metallodrugs

• 1. Introduction
• 2. Redox-Active Metal Complexes
• 3. Complexes With Reactive Metal Centers
• 4. Complexes That Release Carbon Monoxide
• 5. Metal Centers as Structural Templates
• 6. Outlook

Chapter Eight. Carbon Nanotubes and Related Nanohybrids Incorporating Inorganic Transition Metal Compounds and Radioactive Species as Synthetic Scaffolds for Nanomedicine Design

• 1. Introduction
• 2. Positron Emission Tomography–Single-Photon Emission Computed Tomography Metal Complex Bioconjugates
• 3. Potential Application of Carbon Nanomaterial Nanohybrids Incorporating Inorganic Transition Metal Complexes in Biomedical Applications
• 4. Conclusions and Future Prospects

Chapter Nine. Immobilized Metal Affinity Chromatography (IMAC) for Metalloproteomics and Phosphoproteomics

• 1. Introduction
• 2. Principles and Design of Immobilized Metal Affinity Chromatography Columns
• 3. Immobilized Metal Affinity Chromatography for Metalloproteomic Study
• 4. Immobilized Metal Affinity Chromatography for the Analysis of Protein Phosphorylation
• 5. Novel Polymer-Based Metal Ion Affinity Capture: Alternative to Immobilized Metal Affinity Chromatography
• 6. Conclusion

Chapter Ten. The Analysis of Therapeutic Metal Complexes and Their Biomolecular Interactions

• 1. Introduction
• 2. Metallodrug Binding to Blood Serum Proteins
• 3. Tissue Distribution and Cellular Accumulation
• 4. Cellular Targets
• 5. Conclusions