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Inhaled Medicines - 1st Edition - ISBN: 9780128149744

Inhaled Medicines

1st Edition

Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches

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Editors: Stavros Kassinos Per Backman Joy Conway Anthony Hickey
Paperback ISBN: 9780128149744
Imprint: Academic Press
Published Date: 1st December 2020
Page Count: 550
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Description

Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches aims to show that technological ingredients for inhaled medicines are in place, setting the stage for a future of inhaled drug development based in large part on in silico studies. Opportunities and challenges are addressed by a number of experts who tackle drug delivery problems from different scientific angles. Chapters discuss regional deposition in vivo via respiratory imaging and experimental in vivo assessments of deposition that can be complimented by in vitro models in combination with in silico methods, amongst other timely topics.

Key Features

  • Gives a concise accounting of the-state-of-the art in key areas and technologies such as medical imaging, in silico methods, and device and drug formulation
  • Provides a clear description of the development, regulation and approval cycle of inhaled drugs
  • Considers healthcare needs driving the field, and where inhaled drugs could have the maximum impact

Readership

Pharmaceutical scientists and engineers working on inhalation products: including researchers in basic research and development, academic researchers, industrial researchers, doctoral researchers, and senior researchers; Regulators, policy makers, and funding agencies who require an overview of the potential of the technologies involved with inhaled medicines

Table of Contents

Section A: Introduction, medical need, current and future trends in drug and product development for inhalation drug delivery
1. Inhalation medicines: History, current and emerging medical needs
2. The optimal drug
3. Device and formulation

Section B: Understanding clinical performance
4. Understanding clinical performance of an inhaled medicine
5. Fate of the deposited dose: clinical methods to assess
6. Dose deposition pattern: In vitro measures
7. Dose Deposition pattern: In silico measures
8. Dissolution/drug release 
9. Local particulate clearance
10. Permeation and transport in airways 
11. Lung tissue interactions – approaching free concentrations in lung tissue target interaction

Section C: Bringing it all together – the role of in silico computational models
12. PK/ PBPK and mechanistic models:
13. In Silico Population Studies: Pulmonary imaging and simulations as an approach
14. The emerging state of the art: supporting the clinic
15. The emerging state of the art: supporting the product development, approval and regulation cycle

Details

No. of pages:
550
Language:
English
Copyright:
© Academic Press 2021
Published:
1st December 2020
Imprint:
Academic Press
Paperback ISBN:
9780128149744

About the Editors

Stavros Kassinos

Stavros Kassinos is Professor, Computational Sciences Laboratory, University of Cyprus and Computational Science Leader at the University of Cyprus. His research interests center on turbulence and the simulation and modelling of complex physical systems. The overall goal of his research is the understanding of fundamental processes in complex fluid flows and the application of this understanding to the development of new simulation methods in engineering applications. Areas of interest include transport and dispersion in turbulent flows, biological flows with emphasis on inhalation drug delivery, MHD turbulent and laminar flows, and environmental flows. He has been the chair of COST Action MP1404 – “SimInhale”, which has inspired this book. He has served as visiting faculty in the Department of Radiology of the Stanford School of Medicine. Previously, he has worked in the Mechanical Engineering Department at Stanford University as a Postdoctoral Fellow, and as Senior Research Staff at the Stanford/NASA-Ames Center for Turbulence Research (CTR). He held a joint appointment at the Center for Integrated Turbulence Simulations (CITS) at Stanford University. He also holds a Ph.D. from Stanford University.Stavros Kassinos is Professor, Computational Sciences Laboratory, University of Cyprus and Computational Science Leader at the University of Cyprus. His research interests center on turbulence and the simulation and modelling of complex physical systems. The overall goal of his research is the understanding of fundamental processes in complex fluid flows and the application of this understanding to the development of new simulation methods in engineering applications. Areas of interest include transport and dispersion in turbulent flows, biological flows with emphasis on inhalation drug delivery, MHD turbulent and laminar flows, and environmental flows. He has been the chair of COST Action MP1404 – “SimInhale”, which has inspired this book. He has served as visiting faculty in the Department of Radiology of the Stanford School of Medicine. Previously, he has worked in the Mechanical Engineering Department at Stanford University as a Postdoctoral Fellow, and as Senior Research Staff at the Stanford/NASA-Ames Center for Turbulence Research (CTR). He held a joint appointment at the Center for Integrated Turbulence Simulations (CITS) at Stanford University. He also holds a Ph.D. from Stanford University.

Affiliations and Expertise

Professor, Computational Sciences Laboratory (UCY-CompSci), Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus

Per Backman

Per Backman is a Senior Inhalation Consultant at Emmace Consulting AB in Lund, Sweden

Affiliations and Expertise

Senior Inhalation Consultant, Emmace Consulting AB, Lund, Sweden

Joy Conway

Professor Joy Conway works in Respiratory Sciences at the Centre for Health and Life Sciences in Brunel University, London, UK.

Affiliations and Expertise

Professor, Respiratory Sciences, Centre for Health and Life Sciences, Brunel University, London, UK

Anthony Hickey

Dr. Hickey is Distinguished RTI Fellow, at the Research Triangle Institute and Director of the UNC Catalyst for Rare Diseases of the Eshelman School of Pharmacy He obtained Ph.D. and D.Sc. degrees in pharmaceutical sciences from Aston University, Birmingham, UK. He is a Fellow of the Royal Society of Biology, the American Association of Pharmaceutical Scientists, the American Association for the Advancement of Science and the Royal Society of Medicine. He received the Research Achievement Award of the Particulate Presentations and Design Division of the Powder Technology Society of Japan, the Distinguished Scientist Award of the American Association of Indian Pharmaceutical Scientists; the David W Grant Award in Physical Pharmacy of the American Association of Pharmaceutical Scientists; Thomas T Mercer Joint Prize for Excellence in Inhaled Medicines and Pharmaceutical Aerosols of the American Association for Aerosol Research and the International Society for Aerosols in Medicine and the Ralph Shangraw Memorial Award for Excipient and Excipient Technology of the International Pharmaceutical Excipient Consortium Foundation. He is founder (and formerly President and CEO) of Cirrus Pharmaceuticals, Inc., acquired by Kemwell Pharma; founder (formerly CSO, 2002-2007) of Oriel Therapeutics, Inc, acquired by Sandoz and founder and CEO of Astartein, Inc.; member of the Pharmaceutical Dosage Forms Expert Committee of the United States Pharmacopeia and formerly Chair of the Aerosols Expert Committee of the USP. Dr. Hickey conducts multidisciplinary research programs in the field of pulmonary drug and vaccine delivery for the treatment and prevention of a variety of diseases and oversees research in target and candidate therapeutic agent identification for rare and neglected diseases.

Affiliations and Expertise

Distinguished Fellow, Engineered Systems, RTI International, Research Triangle Park, NC, USA

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