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Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches aims to show that technological ingredients for inhaled medicines are in place, setting the stage for a future of inhaled drug development based in large part on in silico studies. Opportunities and challenges are addressed by a number of experts who tackle drug delivery problems from different scientific angles. Chapters discuss regional deposition in vivo via respiratory imaging and experimental in vivo assessments of deposition that can be complimented by in vitro models in combination with in silico methods, amongst other timely topics.
- Gives a concise accounting of the-state-of-the art in key areas and technologies such as medical imaging, in silico methods, and device and drug formulation
- Provides a clear description of the development, regulation and approval cycle of inhaled drugs
- Considers healthcare needs driving the field, and where inhaled drugs could have the maximum impact
Pharmaceutical scientists and engineers working on inhalation products: including researchers in basic research and development, academic researchers, industrial researchers, doctoral researchers, and senior researchers; Regulators, policy makers, and funding agencies who require an overview of the potential of the technologies involved with inhaled medicines
Section A: Introduction, medical need, current and future trends in drug and product development for inhalation drug delivery
1. Inhalation medicines: History, current and emerging medical needs
2. The optimal drug
3. Device and formulation
Section B: Understanding clinical performance
4. Understanding clinical performance of an inhaled medicine
5. Fate of the deposited dose: clinical methods to assess
6. Dose deposition pattern: In vitro measures
7. Dose Deposition pattern: In silico measures
8. Dissolution/drug release
9. Local particulate clearance
10. Permeation and transport in airways
11. Lung tissue interactions – approaching free concentrations in lung tissue target interaction
Section C: Bringing it all together – the role of in silico computational models
12. PK/ PBPK and mechanistic models:
13. In Silico Population Studies: Pulmonary imaging and simulations as an approach
14. The emerging state of the art: supporting the clinic
15. The emerging state of the art: supporting the product development, approval and regulation cycle
- No. of pages:
- © Academic Press 2021
- 1st December 2020
- Academic Press
- Paperback ISBN:
Per Backman is a Senior Inhalation Consultant at Emmace Consulting AB in Lund, Sweden
Professor Joy Conway works in Respiratory Sciences at the Centre for Health and Life Sciences in Brunel University, London, UK.
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