Inflammation and Immunity in Depression - 1st Edition - ISBN: 9780128110737

Inflammation and Immunity in Depression

1st Edition

Basic Science and Clinical Applications

Editors: Bernhard Baune
Paperback ISBN: 9780128110737
Imprint: Academic Press
Published Date: 1st June 2018
Page Count: 304
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Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder.

Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression.

Key Features

  • Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry
  • Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system
  • Explores translational potential of targeting immune dysfunction for clinical interventions


Advanced students and researchers in neuroscience, neuroimmunology, psychoneuroimmunology, affective neuroscience, psychiatry, and psychology, as well as clinicians treating depression and depressive disorder

Table of Contents

1. Introduction
2. Immunological foundations relevant to depression
3. Neuroinflammation in a model of cytokine-induced depression
4. Inflammation in medical-depression comorbidities
5. Neurobiological functions of T cells
6. The role of T-cells in depression
7. Neuroinflammation in post-mortem studies of depression
8. Microglia in depression
9. Animal models of inflammation in depression
10. Epigenetic changes in the immune systems following early life stress
11. The role of the innate immune system in neurodegeneration
12. Inflammation genetics of depression
13. Microglia and neurobiological effects of inflammation in the brain
14. Stress, inflammation and structural brain changes in depression
15. Structural Neuroimaging of inflammation in depression
16. The nerve-gut-inflammation interaction in depression
17. Stress, inflammation and the social brain in depression
18. Epidemiological evidence for the long-term relationship between childhood maltreatment and adult depression
19. Biological embedding of childhood maltreatment in adult depression
20. Inflammation and old age depression
21. Inflammation in clinical depression
22. Role of inflammation in subtypes of depression, recurrent depression and treatment resistant depression
23. The neuroprogression model of depression
24. Inflammation in bipolar depression
25. Neuroprotection and neuroinflammation in depression
26. Sleep disturbance on inflammation and depression risk
27. Clinical anti-inflammatory treatments of depression
28. Efficacy of anti-inflammatory treatments in depression
29. TNF-targeted treatment for depression: does it work, for whom and why?
30. Effects of physical exercise on inflammation in depression
31. Future directions


No. of pages:
© Academic Press 2018
Academic Press
Paperback ISBN:

About the Editor

Bernhard Baune

Professor Baune is Chair of Psychiatry and Head of the Discipline of Psychiatry at the University of Adelaide, Australia, and is a specialist psychiatrist internationally recognized for his work in the field of depression. He was the first researcher to link inflammation genetics with brain function (fMRI) and clinical treatment response, and has done significant work on the role of inflammatory and immunological genetic and non-genetic markers in various psychiatric conditions. He is the author of more than 260 peer-reviewed publications in such journals as The New England Journal of Medicine and The Lancet, and is the editor of the forthcoming book Cardiovascular Diseases in Depression (Springer).

Affiliations and Expertise

Professor and Chair of Psychiatry, Discipline of Psychiatry, School of Medicine, University of Adelaide, Australia

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