Inflammation and Immunity in Depression - 1st Edition - ISBN: 9780128110737, 9780128110744

Inflammation and Immunity in Depression

1st Edition

Basic Science and Clinical Applications

Editors: Bernhard Baune
eBook ISBN: 9780128110744
Paperback ISBN: 9780128110737
Imprint: Academic Press
Published Date: 26th May 2018
Page Count: 636
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Description

Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder.

Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression.

Key Features

  • Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry
  • Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system
  • Explores translational potential of targeting immune dysfunction for clinical interventions

Readership

Advanced students and researchers in neuroscience, neuroimmunology, psychoneuroimmunology, affective neuroscience, psychiatry, and psychology, as well as clinicians treating depression and depressive disorder

Table of Contents

7. The Roles of T Cells in Clinical Depression
CATHERINE TOBEN, BERNHARD T. BAUNE
8. Do Chemokines Have a Role in the Pathophysiology of Depression?
GAURAV SINGHAL, BERNHARD T. BAUNE
9. Inflammasomes Action as an Important Mechanism in Experimental and Clinical Depression
GAURAV SINGHAL, BERNHARD T. BAUNE
10. Pathways Driving Neuroprogression in Depression: The Role of Immune Activation
GIOVANNI ORIOLO, IRIA GRANDE, ROCI´O MARTIN-SANTOS, EDUARD VIETA, ANDR
11. Gene Expression of Inflammation Markers in Depression
LILIANA G. CIOBANU, BERNHARD T. BAUNE
12. Neuroimmunopharmacology at the Interface of Inflammation and Pharmacology Relevant to Depression
JOSHUA HOLMES, FRANCES CORRIGAN, MARK HUTCHINSON
13. The Gut-Brain-Microbe Interaction: Relevance in Inflammation and Depression
NATALIE PARLETTA
14. Childhood Trauma and Adulthood Immune Activation
MARIA A. NETTIS, VALERIA MONDELLI
15. Stress, Maltreatment, Inflammation, and Functional Brain Changes in Depression
KELLY DOOLIN, LEONARDO TOZZI, JOHANN STEINER, THOMAS FRODL
16. Structural Neuroimaging of Maltreatment and Inflammation in Depression
RONNY REDLICH, NILS OPEL, KATHARINA F FÖRSTER, JENNIFER ENGELEN, UDO DANNLOWSKI
17. Biological Embedding of Childhood Maltreatment in Adult Depression
MAGDALENE C. JAWAHAR, BERNHARD T. BAUNE
18. Epigenetic Changes in the Immune Systems Following Early-Life Stress
CHRIS MURGATROYD
19. Mechanisms Linking Depression, Immune System and Epigenetics During Aging
STEVEN BRADBURN
20. Role of Inflammation in Neuropsychiatric Comorbidity of Obesity: Experimental and Clinical Evidence
C
21. Inflammation and Depression in Patients With Autoimmune Disease, Diabetes, and Obesity
JONATHAN M. GREGORY, MICHAEL MAK, ROGER S. MCINTYRE
22. Does Inflammation Link Clinical Depression and Coronary Artery Disease?
SILKE J JÖRGENS, VOLKER AROLT
23. Inflammation Genetics of Depression
MICHAEL MUSKER, JULIO LICINIO, MA-LI WONG
24. Adolescent-Onset Depressive Disorders and Inflammation
IAN HICKIE, JOANNE CARPENTER, ELIZABETH SCOTT
25. Inflammation in Bipolar Disorder
JOSHUA D. ROSENBLAT, JONATHAN M. GREGORY, SOPHIE FLOR-HENRY, ROGER S. MCINTYRE
26. Depression Subtypes and Inflammation: Atypical Rather Than Melancholic Depression Is Linked With Immunometabolic Dysregulations
FEMKE LAMERS, YURI MILANESCHI, BRENDA W.J.H. PENNINX
27. Inflammation as a Marker of Clinical Response to Treatment: A Focus on Treatment-Resistant Depression
REBECCA STRAWBRIDGE, ALLAN H. YOUNG, ANTHONY J. CLEARE
28. Clinical Trials of Anti-Inflammatory Treatments of Major Depression?
NORBERT MÜLLER
29. Alcohol, Inflammation, and Depression: The Gut-Brain Axis
ABIGAIL R. CANNON, ADAM M. HAMMER, MASHKOOR A. CHOUDHRY
30. Efficacy of Anti-Inflammatory Treatment in Depression
OLE KÖHLER-FORSBERG, MICHAEL ERIKSEN BENROS
31. Modulation of Inflammation by Antidepressants
BERNHARD T. BAUNE
32. The Biological Underpinnings of Mood Disorders Interact With Early Trauma, Sexual Abuse and Neuroticism: Implications for Psychiatric Classification and Treatment
GEORGE ANDERSON, MICHAEL MAES
33. Is There Still Hope for Treating Depression With Antiinflammatories?
BERNHARD T. BAUNE
34. Effects of Physical Exercise on Inflammation in Depression
HARRIS A. EYRE, KATARINA ARANDJELOVIC, DAVID A MERRILL, AJEET B SINGH, HELEN LAVRETSKY
35. Future Perspectives on Immune-Related Treatments
BERNHARD T. BAUNE

Details

No. of pages:
636
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
eBook ISBN:
9780128110744
Paperback ISBN:
9780128110737

About the Editor

Bernhard Baune

Professor Baune is Chair of Psychiatry and Head of the Discipline of Psychiatry at the University of Adelaide, Australia, and is a specialist psychiatrist internationally recognized for his work in the field of depression. He was the first researcher to link inflammation genetics with brain function (fMRI) and clinical treatment response, and has done significant work on the role of inflammatory and immunological genetic and non-genetic markers in various psychiatric conditions. He is the author of more than 420 peer-reviewed publications in such journals as The New England Journal of Medicine, The Lancet, Nat Genetics, JAMA Psychiatry and Mol Psychiatry.

Affiliations and Expertise

Professor and Chair of Psychiatry, Discipline of Psychiatry, School of Medicine, University of Adelaide, Australia

Ratings and Reviews