Description

This new volume of Advances in Pharmacology explores the current state of Alzheimer's disease research and therapeutics. Chapters cover such topics as the B cell targeted therapies, Lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

Key Features

  • Explores the current state of Alzheimer's disease research and therapeutics
  • Chapters cover a variety of topics such as the B cell targeted therapies, lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin
  • With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike

Readership

Pharmacologists, immunologists, and biochemists

Table of Contents

Preface

Contributors

Chapter One. Redefining Approaches to Asthma: Developing Targeted Biologic Therapies

Abstract

1. Introduction

2. Human Asthma Biology

3. Pharmacokinetics and Pharmacodynamics of Asthma Biologics

4. Clinical Study Design for Asthma Biologics

5. Conclusion

Acknowledgments

References

Chapter Two. Protein Therapeutics Targeted at the TNF Superfamily

Abstract

1. Introduction

2. The TNF and TNF Receptor Superfamilies

3. Antibody and Receptor-Based Drugs

4. Clinical Responses to TNF Inhibitors

5. Targeting Other TNFSF Pathways

6. Conclusion

Acknowledgments

References

Chapter Three. Immunopharmacology of Lipid A Mimetics

Abstract

1. Introduction

2. LPS Receptor Complex

3. TLR4 Signaling

4. Endotoxin

5. Structure of LPS

6. Lipid A: The “Endotoxic Principle”

7. Diversity of Lipid A in Nature

8. Synthetic Lipid A

9. TRIF-Selective Signaling

10. Conclusion

References

Chapter Four. The Biology of Thymic Stromal Lymphopoietin (TSLP)

Abstract

1. Introduction

2. TSLP Signaling

3. TSLP-Responsive Cells

4. TSLP-Associated Diseases

5. Conclusion

Acknowledgments

References

Chapter Five. Eicosanoids in Metabolic Syndrome

Abstract

1. Introduction

2. Lipid Metabolism in Control of Eicosanoid Synthesis

3. Metabolism of Eicosanoids in MetS

4. Eicosanoids in Sepsis and Drug Metabolism

5. Eicosanoids and MetS Diseases

6. Therapies in the Treatment of NAFLD

7. Conclusion

Acknowledgments

References

Chapter Six. The Yin and Yang of Protein Kinase C-theta (PKCθ): A Novel Drug Target for Selective Immunosuppression

Abstract

Details

No. of pages:
352
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
eBook ISBN:
9780124051843
Print ISBN:
9780124047174

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