Immunopharmacology

Immunopharmacology

1st Edition - February 18, 2013

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  • Editor: David Webb
  • eBook ISBN: 9780124051843

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Description

This new volume of Advances in Pharmacology explores the current state of Alzheimer's disease research and therapeutics. Chapters cover such topics as the B cell targeted therapies, Lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

Key Features

  • Explores the current state of Alzheimer's disease research and therapeutics
  • Chapters cover a variety of topics such as the B cell targeted therapies, lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin
  • With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike

Readership

Pharmacologists, immunologists, and biochemists

Table of Contents

  • Preface

    Contributors

    Chapter One. Redefining Approaches to Asthma: Developing Targeted Biologic Therapies

    Abstract

    1. Introduction

    2. Human Asthma Biology

    3. Pharmacokinetics and Pharmacodynamics of Asthma Biologics

    4. Clinical Study Design for Asthma Biologics

    5. Conclusion

    Acknowledgments

    References

    Chapter Two. Protein Therapeutics Targeted at the TNF Superfamily

    Abstract

    1. Introduction

    2. The TNF and TNF Receptor Superfamilies

    3. Antibody and Receptor-Based Drugs

    4. Clinical Responses to TNF Inhibitors

    5. Targeting Other TNFSF Pathways

    6. Conclusion

    Acknowledgments

    References

    Chapter Three. Immunopharmacology of Lipid A Mimetics

    Abstract

    1. Introduction

    2. LPS Receptor Complex

    3. TLR4 Signaling

    4. Endotoxin

    5. Structure of LPS

    6. Lipid A: The “Endotoxic Principle”

    7. Diversity of Lipid A in Nature

    8. Synthetic Lipid A

    9. TRIF-Selective Signaling

    10. Conclusion

    References

    Chapter Four. The Biology of Thymic Stromal Lymphopoietin (TSLP)

    Abstract

    1. Introduction

    2. TSLP Signaling

    3. TSLP-Responsive Cells

    4. TSLP-Associated Diseases

    5. Conclusion

    Acknowledgments

    References

    Chapter Five. Eicosanoids in Metabolic Syndrome

    Abstract

    1. Introduction

    2. Lipid Metabolism in Control of Eicosanoid Synthesis

    3. Metabolism of Eicosanoids in MetS

    4. Eicosanoids in Sepsis and Drug Metabolism

    5. Eicosanoids and MetS Diseases

    6. Therapies in the Treatment of NAFLD

    7. Conclusion

    Acknowledgments

    References

    Chapter Six. The Yin and Yang of Protein Kinase C-theta (PKCθ): A Novel Drug Target for Selective Immunosuppression

    Abstract

    1. Introduction

    2. History, Structure and Expression of PKCθ

    3. Specialized Functions of PKCθ in Conventional T Cells: The Yin

    4. The Differential Role of PKCθ in Immune Responses

    5. PKCθ and the Immunological Synapse

    6. PKCθ, CD28 Costimulation, and T Cell Anergy

    7. Unique Function of PKCθ in Regulatory T Cell Development and Function: The Yang

    8. PKCθ in Human Disease

    9. Is PKCθ a Promising Drug Target?

    10. Conclusion and Future Perspectives

    Acknowledgments

    References

    Index

Product details

  • No. of pages: 352
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: February 18, 2013
  • Imprint: Academic Press
  • eBook ISBN: 9780124051843

About the Editor

David Webb

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