Immunology of Endometriosis

Immunology of Endometriosis

Pathogenesis and Management

1st Edition - December 1, 2021

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  • Editor: Kaori Koga
  • Paperback ISBN: 9780128206614
  • eBook ISBN: 9780128209059

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Immunology of Endometriosis: Etiology and Management, a volume in the Reproductive Immunology series, provides updates on one of most common gynecological diseases, including basic science concepts and their clinical applications related to endometriosis immunology. Various immunological factors are believed to play roles in the pathogenesis of endometriosis, providing potential targets for the disease. Endometriosis is now considered to be a disease of both endocrine and immune dysregulation. However, recognition of the direct involvement of two major physiological mechanisms brings about a change of focus which might represent an interesting advance in the understanding of this disease and new focus for further research.

Key Features

  • Provides detailed immunological background to help readers understand etiology and management of endometriosis
  • Evaluates various immunological factors that are involved in the pathogenesis of endometriosis
  • Presents a detailed evaluation of the knowledge related to each immune cell type in endometriosis


Medical and research. Researchers, Clinicians and trainees working in the field of endometriosis

Table of Contents

  • 1. B lymphocytes
    L.G.C. Riccio and M.S. Abrão
    2. Macrophages in endometriosis: they came, they saw, they conquered
    Kavita Panir, Mary Louise Hull, and Erin Greaves
    3. Dendritic cells
    Gentaro Izumi
    4. Immune factors in the pathogenesis and the potential therapeutic target of endometriosis 1e4 neutrophils
    Masashi Takamura
    5. Role of Th1, Th2, Th17, and regulatory T cells in endometriosis
    Khaleque N. Khan, Akira Fujishita, Yukiko Tanaka, and Jo Kitawaki
    6. Auto-immunity and endometriosis: evidence, mechanism and therapeutic potential
    Tao Zhang, Tin-Chiu Li, and Chi-Chiu Wang
    7. Role of estrogen and estrogen-related factors in endometriosis
    Taisuke Mori and Jo Kitawaki
    8. Immune factors in the pathogenesis and the potential therapeutic target of endometriosis
    Wan-Ning Li, Meng Hsing Wu, and Shaw-Jenq Tsai
    9. The roles and functions of macrophages in endometriosis
    Miaomiao Ji, Xue Jiao, Sun-Wei Guo, and Guoyun Wang
    10. The role of immune factors in endometriosis-related conditions, 2-1 pain
    Fabio Barra, Giulio Evangelisti, Carolina Scala, and Simone Ferrero
    11. Immune phenotypes and mediators affecting endometrial function in women with endometriosis
    Linda C. Giudice and Julia Vallve Juanico
    12. The role of immune factors in endometriosis-related conditions, 2e3 ovarian dysfunction
    Michio Kitajima
    13. The role of immune-related redox biology in malignant transformation of endometriosis
    Hiroshi Kobayashi
    14. Pregnancy complications
    Louis Marcellin, Pietro Santulli, and Charles Chapron
    15. Prevalent innate and adaptive immune mechanisms in endometriosis
    Ryan M. Marks, Harshavardhan Lingegowda, Alison McCallion, Anushka Nair, and Chandrakant Tayade
    16. Novel therapeutic strategy: antiinflammatory reagents
    Hiroaki Komatsu, Fuminori Taniguchi, and Tasuku Harada
    17. Gut microbiota and endometriosis
    Osamu Yoshino, Yosuke Ono, and Takehiro Hiraoka
    18. Immunosuppression and immunotherapy in endometriosis: review of pathophysiology, recent development and future perspectives
    Ying He, Kennes Sze Wan Hung, Hui Xu, and Chi Chiu Wang
    19. Novel diagnostic strategies for endometriosis
    Mathew Leonardi, Jodie Avery, and M. Louise Hull

Product details

  • No. of pages: 348
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: December 1, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780128206614
  • eBook ISBN: 9780128209059

About the Editor

Kaori Koga

Kaori Koga, M.D., Ph.D. is a physician-scientist and an Associate Professor of the Department of Obstetrics and Gynecology, School of Medicine at the University of Tokyo, Japan. Dr. Koga received her M.D. degree from Chiba University, Chiba, Japan, and her Ph.D. degree from the University of Tokyo. She undertook post-doctoral fellowships in the Uterine Biology Group (Prof. Lois Salamonsen’s laboratory) at Prince Henry’s Institute, Melbourne, Australia in 2006, and the Reproductive Immunology Unit (Prof. Gil Mor’s laboratory) at the Department of Obstetrics, Gynecology and Reproductive Sciences in Yale University in 2006–2008. Dr. Koga's keen interest lies in Reproductive Immunology, with particular focus on endometriosis and infertility. As a gynecological clinician, Dr. Koga has treated many patients with endometriosis and has performed Minimally Invasive Surgery and Aassisted Reproductive Technology. Dr. Koga has received numerous national and international awards, including Kanzawa Award from the Kanzawa Medical Research Foundation in 2018 and Guston Award from the American Society for Reproductive Immunology (ASRI) in 2008. She is a member of the ASRI, the International Society for Immunology of Reproduction (ISIR) as well as of the European Society of Human Reproduction and Embryology (ESHRE), and an ambassador of the World Endometriosis Society (WES). Dr Koga is an Associate Editor of Human Reproduction Open (2021–) and serves on the editorial boards of the American Journal of Reproductive Immunology, and the Journal of Reproductive Immunology.

Affiliations and Expertise

Associate Professor of the Department of Obstetrics and Gynecology, School of Medicine at the University of Tokyo, Japan

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