Immunoglobin Genes is the first comprehensive book on the structure, function, and expression of the genes encoding antibodies in normal and neoplastic cells.
Immunologists, molecular biologists and geneticists, and cell biologists.
(Section Headings): B Cells. Organization and Rearrangement of Immunoglobulin Genes. Immunoglobulin Genes in Disease. Immunoglobulin Gene Expression. Immunoglobulin-Related Genes.
- No. of pages:
- © Academic Press 1989
- 28th January 1989
- Academic Press
- eBook ISBN:
Dr. Tasuku Honjo graduated from Kyoto University Faculty of Medicine in 1966 (M.D.). After obtaining his Ph.D. in Biochimistry (Dr. O. Hayaishi), he spent 4 years in the U.S.A. as a postdoctoral fellow first in Carnegie Institution of Washington (Dr. D. Brown), and then in NIH (Dr. P. Leder) where he initiated studies on immunoglobulin genes. He returned to Tokyo University as an assistant professor in 1974, and then moved to Osaka University School of Medicine as Professor of Genetics in 1979. He succeeded to Dr. O. Hayaishi after his retirement at the Department of Medical Chemistry in Kyoto University. He also served as Dean of Medical School (1996-2000 and 2004-2005), and Executive Member of Council for Science and Technology Policy, Cabinet Office (2006-2012). Currently, he is Professor of Department of Immunology and Genomic Medicine, Kyoto University, and also Chairman of Board of Directors, Shizuoka Prefectural University Corporation.
Dr. Honjo is well known for his discovery of activation-induced cytidine deaminase that is essential for class switch recombination and somatic hypermutation. He has established the basic conceptual framework of class switch recombination starting from discovery of DNA deletion (1978) and S regions (1980), followed by elucidation of the whole mouse immunoglobulin heavy-chain locus. His contribution further extended to cDNA cloning of IL-4 and IL-5 cytokines involved in class switching and IL-2 receptor alpha chain. Aside from class switching recombination, he discovered PD-1 (program cell death 1), a negative coreceptor at the effector phase of immune response and showed that PD-1 modulation contributes to treatments of viral infection, tumor and autoimmunity. In addition, he is known to be a discoverer of RBP-J, a nuclear protein that interacts with the intracellular domain of Notch in the nucleus. Notch/RBP-J signaling has been shown to regulate a variety of cell lineage commitment including T and B cells.
For these contributions, Dr. Honjo has received many awards, including the Noguchi Hideyo Memorial Prize for Medicine (1981), Imperial Prize, Japan Academy Prize (1996), Robert Koch Prize (2012), and Order of Culture (2013). He is an honorary member of the American Association of Immunologists. He has been honored by the Japanese Government as a person of cultural merits (2000). He has also been elected as a foreign associate of National Academy of Sciences, USA in 2001, as a member of Leopoldina, the German Academy of Natural Scientists in 2003, and as a member of Japan Academy in 2005.
Kyoto University, Japan
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA
@qu:"This book will be most useful to experienced immunologists and, as the editors point out, to molecular biologists...The timing of Immunoglobulin Genes is excellent. It summarizes the experiments and theories in a field with a solid foundation. It shoud be an important reference book." @source:--SCIENCE @qu:"This volume is well written and well presented. This book will be of great use to those just beginning a career in immunology or to those in other fields wishing to familiarize themselves with the subject." @source:--TRENDS IN BIOCHEMICAL SCIENCES @qu:"The organization of this book and the clear, concise nature of each chapter provides an excellent introduction to all aspects of immunoglobulin genes and proteins for the person beginning in this field of research or wanting to gain a further understanding of this area. For the experienced person, this book provides an overview of all areas and is a good reference for the major developments in this field." @source:--QUARTERLY REVIEW OF BIOLOGY @qu:"As a celebration of the molecular achievements in the field, Immunoglobulin Genes is a benchmark reference....This volume appears at an appropriate time, and will be valuable as a detailed resource on the classic molecular genetics of immunoglobulin." @source:--CANCER CELLS, A MONTHLY REVIEW @qu:"...an excellent reference text for anyone wishing to know more about the immunoglobulins and I would certainly recommend it." @source:--JOURNAL OF CLINICAL PATHOLOGY