Immunobiology of the Macrophage

Immunobiology of the Macrophage

1st Edition - January 28, 1976

Write a review

  • Editor: David S. Nelson
  • eBook ISBN: 9781483274775

Purchase options

Purchase options
DRM-free (EPub, Mobi, PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book’s contributors—immunologists of diverse scientific and geographic backgrounds—have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed by separate chapters on topics such as the role of macrophages in making antigen more immunogenic and less tolerogenic; functional distinctions between macrophages at different sites; and the role of the macrophage in antigen recognition by T lymphocytes. Subsequent chapters examine interactions between macrophages and lymphocytes in the production of interferon and other mediators of cellular immunity; macrophage cell lines and their uses in immunobiology; and cytotoxic macrophages in allograft rejection.

Table of Contents


  • List of Contributors

    Preface

    Introduction

    1 The Role of Macrophages in Antibody Responses In Vitro

    I. Introduction

    II. Antibody Responses In Vitro

    III. Introductory Immunogenetics

    IV. Requirements for Macrophages in Antibody Responses In Vitro

    V. Functions of Macrophages in Antibody Responses In Vitro

    VI. Immunogenetic Considerations of Macrophage Functions in Antibody Responses In Vitro

    VII. Conclusions, Present State of the Art, and the Future

    VIII. Note Added in Proof

    References

    2 The Role of Macrophages in the Specific Determination of Immunogenicity and Tolerogenicity

    I. Introduction

    II. In Vitro Requirements for Cell Activation by DNP-D-GL

    III. Characteristics of an Antigen Which Does Not Require Macrophage Processing

    IV. Macrophage Roles in Cell Activation

    References

    3 Role of Macrophages in T Cell-B Cell Collaboration in Antibody Production

    I. Introduction

    II. Immunobiology of T Cell-B Cell Collaboration

    III. Role of Macrophages in T Cell-B Cell Collaboration

    IV. Mechanisms of T Cell-B Cell Collaboration

    V. T Cell-B Cell Collaboration In Vivo

    References

    4 Functional Heterogeneity of Macrophages

    I. Introduction

    II. Functional Heterogeneity of Macrophages from Different Tissues

    III. Functional Heterogeneity of Macrophages from the Same Tissue

    IV. Conclusions

    References

    5 The Role of Macrophages in the Induction of Cell-Mediated Immunity In Vivo

    I. Introduction

    II. Contribution of Macrophages to Induction of Delayed Hypersensitivity Reactions and in Priming Helper T Cells for Antibody Production

    III. Relationship of Macrophage Presentation and Processing of Antigens to Induction of Cell-Mediated Immunity

    IV. Regulation of Immunogenicity of Macrophage-Associated Antigens

    V. Summary and Conclusions

    References

    6 Macrophage Function in Antigen Recognition by T Lymphocytes

    I. Introduction

    II. Macrophages are Required for Antigen Recognition by T Lymphocytes

    III. Interaction between Macrophage and Soluble Antigen in the Immune Response

    IV. Genetic Regulation of Functional Macrophage-Lymphocyte Interaction

    V. Physical Interactions between Macrophages and Lymphocytes

    VI. Role of Macrophages in Nonantigenic Stimulation of T Lymphocytes

    VII. Model Building for the Cellular and Molecular Events in Antigen Recognition by T Lymphocytes

    References

    7 The Role of Macrophages in the Activation of T and R Lymphocytes In Vitro

    I. Introduction

    II. Mechanisms of Action of Macrophages

    III. The Role of Macrophages in Antigen-Induced Lymphocyte Proliferative Responses In Vitro

    IV. The Role of Macrophages in the Response of B and T Lymphocytes to Mitogens In Vitro

    V. The Role of Macrophages in the Activation of Lymphocytes by Allogeneic Cells (MLR)

    VI. The Role of Macrophages in the Activation of B Lymphocytes by Sheep Erythrocytes

    VII. The Role of Macrophages in the Induction of Lymphokine Synthesis by B and T Lymphocytes

    VIII. Summary and Conclusions

    References

    8 The Ability of Macrophages to Augment In Vitro Mitogen- and Antigen-Stimulated Production of Interferon and Other Mediators of Cellular Immunity by Lymphocytes

    I. Introduction

    II. The Ability of Macrophages to Augment Mitogen-Stimulated Production of Interferon by Lymphocytes

    III. The Ability of Macrophages to Augment Bacterial and Viral Antigen-Stimulated Production of Interferon by Lymphocytes

    IV. Macrophages and Their Relationship to the Production of Other Mediators of Cellular Immunity by Lymphocytes 219

    V. Macrophages and Their Role in Affecting the Production of Viral-Induced Interferon by Leukocytes

    VI. Summary

    References

    9 Nonspecific Immunoregulation by Macrophages and Their Products

    I. Introduction

    II. Potentiation of Lymphoid Cell Responses

    III. Inhibition of Lymphoid Cell Responses

    IV. Mode of Action of Macrophages in Depressing Lymphocyte Responses

    V. Significance of Lymphoid Cell Stimulation and Inhibition by Macrophages and Their Products

    References

    10 Macrophage Membranes

    I. Introduction

    II. Probes of Macrophage Surface Organization

    III. Random Mobility of Macrophage Surface Proteins

    IV. Organized Movement of Macrophage Surface Elements

    V. Control of Translational Movements of Receptors and Transport Proteins within the Plane of the Membrane

    VI. Summary

    References

    11 Macrophage Cell Lines and Their Uses in Immunobiology

    I. Introduction

    II. Growth of Primary Macrophages In Vitro

    III. Permanent Lines with Properties of Macrophages

    IV. Conclusion

    References

    12 Monocyte Kinetics and Their Changes in Infection

    I. Introduction

    II. Theoretical and Methodological Background

    III. Cell Kinetics of the Monocytes

    IV. Cell Kinetics of Monocytes in Infection

    V. Concluding Remarks

    References

    13 Chemotaxis of Macrophages

    I. Introduction

    II. Methods for Quantifying Macrophage Chemotaxis

    III. Humoral Factors Chemotactic for Macrophages

    IV. Lymphocyte-Derived Chemotactic Factors

    V. Chemotactic Factors from Bacteria

    VI. Factors Which Alter Monocyte Chemotactic Function

    VII. Abnormalities of Monocyte Chemotaxis in Human Diseases

    VIII. Summary and Conclusions

    References

    14 Cellular and Molecular Aspects of Chemotaxis of Macrophages and Monocytes

    I. Introduction

    II. Locomotion of Different Types of Macrophage

    III. Modes of Macrophage Migration

    IV. Recognition of Chemotactic Factors at the Cell Membrane

    V. Intracellular Events following Interaction of the Chemotactic Factor with the Cell Membrane

    VI. Differential Effects of Bacterial Toxins on Locomotion of Neutrophils and Macrophages

    VII. Recognition in Chemotaxis, Phagocytosis, and Other Macrophage Functions

    VIII. Antigen-Specific Chemotaxis

    IX. Conclusions

    References

    15 Lymphocyte-Macrophage Interactions and Macrophage Activation in the Expression of Antimicrobial Immunity In Vivo

    I. Introduction

    II. Generation of Effector T Cells

    III. Mechanisms of T Cell and Macrophage-Mediated Immunity to Infection

    IV. Conclusions

    References

    16 Macrophage Activation by Lymphocyte Mediators and Studies on the Interaction of Macrophage Inhibitory Factor (MIF) with Its Target Cell

    I. Introduction

    II. Macrophage Activation by Lymphocyte Mediators

    III. Interaction of MIF with the Macrophage

    IV. Biologically Active Substances Produced by Macrophages

    V. Conclusion

    References

    17 Secretion of Macrophage Enzymes in Relation to the Pathogenesis of Chronic Inflammation

    I. Introduction

    II. The Origin and Turnover of Cells in Sites of Chronic Inflammation

    III. In Vitro Studies on the Role of Macrophages in Chronic Inflammation

    IV. What is the Contribution of Hydrolytic Enzyme Secretion to Chronic Inflammation?

    V. Other Products of Macrophages

    VI. Interactions and Modulating Factors

    References

    18 Induction of Macrophage-Mediated Cytotoxicity

    I. Introduction

    II. Macrophage-Mediated Cytotoxicity in Allograft Rejection

    III. Cytotoxic Macrophages in Syngeneic Tumor Systems

    IV. Macrophage-Mediated Cytotoxicity Induced by Infection with Various

    Microorganisms

    V. In Vitro Induction of Macrophage-Mediated Cytotoxicity

    VI. Summary and Implications

    References

    19 Cytostatic and Cytocidal Effects of Activated Macrophages

    I. Introduction

    II. Nomenclature

    III. Cytostatic Effects of Activated Macrophages

    IV. Cytocidal Effects of Macrophages

    V. The Biologic Relevance of the In Vitro Findings

    VI. Critical Outlook

    References

    20 Macrophages and the Destruction of Syngeneic Virus-Induced Tumors

    I. Introduction

    II. Antigenicity of Cells Transformed by Oncogenic Viruses

    III. Immune Response of Syngeneic Host to Virus-Induced Tumors

    IV. Role of Macrophages in Rejection of Virus-Induced Tumors

    V. Steps in the Development of Cell-Mediated Immunity and the Mechanisms of Rejection of DNA Virus-Induced Tumors

    References

    21 Mechanisms of Extracellular Killing of Nucleated Mammalian Cells by Macrophages

    I. Introduction

    II. Specific Macrophage Cytotoxicity

    III. Nonspecific Macrophage Cytotoxicity

    IV. Cytotoxic Macrophages and the Tumor Bearing Host

    V. In Vivo Significance of the Nonspecifically Cytotoxic Macrophage

    VI. Role of Macrophages in Surveillance

    VII. Conclusion

    References

    22 Immunotherapeutic Approaches to Tumors Involving the Skin

    I. Introduction

    II. Clinical Investigations

    III. A Primitive Surveillance Mechanism?

    IV. Summary

    References

    23 Macrophages and Their Disorders in Man

    I. Metabolism

    II. Functions

    III. Disorders of the Monocyte-Macrophage System

    IV. Summary and Future Perspectives

    References

    24 Macrophages: Perspectives and Prospects

    Text

    Index

Product details

  • No. of pages: 652
  • Language: English
  • Copyright: © Academic Press 1976
  • Published: January 28, 1976
  • Imprint: Academic Press
  • eBook ISBN: 9781483274775

About the Editor

David S. Nelson

Ratings and Reviews

Write a review

There are currently no reviews for "Immunobiology of the Macrophage"