Immunobiology of the Complement System

Immunobiology of the Complement System

An Introduction for Research and Clinical Medicine

1st Edition - October 16, 1986

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  • Editor: Gordon D. Ross
  • eBook ISBN: 9781483276397

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Immunobiology of the Complement System: An Introduction for Research and Clinical Medicine provides an introduction to the complement system. The intention was to create a primer that would provide the basic knowledge of complement required for either research or clinical medicine in diseases involving the complement system. The book begins with a historical background of complement research; it introduces certain key investigators from the past who have made important contributions. Separate chapters on the basic aspects of complement function are followed by chapters on the molecular genetics of complement and the role of complement in different diseases. Key topics discussed include the activation of complement via the classical pathway and the alternative pathway; complement mediators of inflammation; opsonization and membrane complement receptors; assembly and functions of the terminal components; and complement-dependent mechanisms of virus neutralization. This book has been written primarily for students and scientists who have not been specifically trained in complement research.

Table of Contents

  • Preface

    Introduction and History of Complement Research

    I. The Complement System

    II. History of Research on Complement

    III. Role of Complement in Infections and Autoimmune Disease

    References of Historical Interest

    1 The Classical Pathway

    I. Introduction

    II. Activation Cascade

    III. Regulatory Factors

    IV. Summary of Amplification Factors


    2 The Alternative Pathway

    I. Introduction

    II. The Proteins

    III. The Activation Process

    IV. Regulation of Alternative Pathway Activation by Membrane-Associated Proteins

    V. Biological Effects of Alternative Pathway Activation


    3 Complement Mediators of Inflammation

    I. Introduction

    II. Production of the Anaphylatoxins

    III. Control Mechanisms

    IV. Physiochemical Characterization of the Human Anaphylatoxins

    V. Biological Activities of the Anaphylatoxins

    VI. The C5a Receptor

    VII. Summary


    4 Opsonization and Membrane Complement Receptors

    I. Introduction

    II. Opsonization

    III. Membrane Complement Receptors

    IV. Methods for Detection of Opsonic Complement Fragments and Complement Receptors


    5 Assembly and Functions of the Terminal Components

    I. Introduction

    II. Assembly of the MAC

    III. Functional Effects of the MAC on Target Membranes

    IV. Escape Mechanisms from MAC Attack

    V. Pathophysiological Significance of the Membrane Attack Sequence

    VI. Protection of Host Cells from Attack by MAC

    VII. Perspectives


    6 Complement-Dependent Mechanisms of Virus Neutralization

    I. Introduction

    II. Immunity to Viruses and Virus-Infected Cells

    III. Complement Activation by Viruses and Virus-Infected Cells

    IV. Antibody- and Complement-Dependent Viral Neutralization

    V. Effects of Antibody and Complement on Virus-Infected Cells

    VI. Conclusions


    7 Genetics and Synthesis of Components of the Complement System

    I. Introduction

    II. Genetic Variants: Polymorphism of the Complement Proteins

    III. Structure and Organization of Complement Genes

    IV. Expression of Complement Genes

    V. Complement Deficiencies

    VI. Conclusions


    8 Role of Complement in Infectious Diseases

    I. Introduction

    II. Microbial Antigens Capable of Activating Complement

    III. Localization of Antibody and Complement Components on Microorganisms

    IV. Complement-Mediated Lysis of Bacteria

    V. Role of Antibody and Complement in Bloodstream Clearance of Microorganisms

    VI. Noncomplement and Nonantibody Factors Interacting with Complement in Host Defense

    VII. Role of Complement in the Pathogenesis of Infectious Disease

    VIII. Conclusions


    9 Complement and the Rheumatic Diseases

    I. Introduction

    II. Systemic Lupus Erythematosus

    III. Rheumatoid Arthritis and Related Arthritides

    IV. Cryoglobulins

    V. Vasculitic Syndromes

    VI. Laboratory Evaluation


    10 Role of Complement in Hemolytic Anemia and Thrombocytopenia

    I. Red Cell Injury

    II. Diseases Involving Complement-Mediated Injury of Inherently Normal Erythrocytes: Immune Hemolytic Disorders

    III. Diseases Involving Complement-Mediated Injury of Inherently Defective Erythrocytes

    IV. Platelet Injury


    11 Genetic Deficiency Diseases of the Complement System

    I. Introduction

    II. Complement Deficiency States in Laboratory Animals

    III. Complement Deficiency in Man

    IV. Association of Complement Deficiency with Disease

    V. Summary



Product details

  • No. of pages: 286
  • Language: English
  • Copyright: © Academic Press 1986
  • Published: October 16, 1986
  • Imprint: Academic Press
  • eBook ISBN: 9781483276397

About the Editor

Gordon D. Ross

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