Immunity to Cancer

Immunity to Cancer

1st Edition - January 28, 1985

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  • Editor: Arnold Reif
  • eBook ISBN: 9780323143561

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Description

Immunity to Cancer documents the proceedings of a conference on ""Immunity to Cancer"" held at Williamsburg, Virginia, September 10-12, 1984. This was the first open conference since the New York Academy of Sciences meeting in 1975 that attempted to address the entire range of topics encompassed by tumor immunology and immunotherapy. The papers presented in this volume were invited from experts in diverse areas of tumor immunology and closely related subjects. There was an attempt to proceed logically from a consideration of the antigenicity of tumors and the use of monoclonal antibodies to examine specific antigens, to a review of regulatory and effector mechanisms. Immunological approaches to therapy were then considered systematically, both for classical modes of immunotherapy and for the newly expanded categories of biological response modifiers or biomodulators. Also included were papers on vaccination against cancer and on the analogy between the strategies for chemotherapy and immunotherapy.

Table of Contents


  • Senior Authors

    Preface

    Acknowledgments

    Section 1 Identification and Characterization of Tumor Antigens

    Some Key Problems for Success of Classical Immunotherapy

    What are Tumor Antigens?

    Antigenicity of Simian Virus 40 Transformed Cells

    Characteristics of Tumor Antigens on Tumors Induced by Chemical Carcinogens: Some Recent Findings

    Immunobiology of RAW117 Large Cell Lymphoma

    Biochemical and Functional Profiles of Two Unique Melanoma Associated Antigens

    Identification and Characterization of Human Leukemia Associated Antigens

    Monoclonal Antibodies Against Gastro-Intestinal Tumor Associated Antigens

    Immunodiagnosis of Malignancy with Monoclonal Antibodies to Cell Surface Antigens Expressed by Non-Neoplastic Cells

    *Human Monoclonal Antibodies that Distinguish Cutaneous Melanomas from Benign Nevi in Fixed Sections

    Section 2 Immune Responses to Tumor Antigens

    Host Response to Epstein-Barr Virus Infected B Cells

    The Role of T Lymphocyte Subsets in the Rejection of 3-Methylcholanthrene Induced Rat Sarcoma Mc7

    The Humoral Immune Response to Human Cancer

    Relevance of Tumor Model Antigenicities to Human Tumor Immunology

    Intensification of Tumor Antigenicity

    Effector Cells of T Cell Lineage

    Macrophage Effector and Regulatory Functions

    Natural Killer (NK) Cells: Characteristics and Possible Role in Resistance Against Tumor Growth

    *UV Light-Induced Increase in Immunogenicity of 3LL Tumor Cells

    Section 3 Regulation of the Immune Response to Tumor Cells

    Suppressor Cells: T Cells and Macrophages

    Idiotypes and Anti-Idiotypes

    Human T-T Cell Interactions

    Lymphokines as Regulators of Tumor Cell Function

    Interferons: Cytostatic and Immunomodulatory Effects

    Possible Role of Iron Depletion as Cause of Tumor Cell Cytotoxicity Induced by Activated Macrophages

    Immunological Surveillance Revisited

    AIDS and Kaposi's Sarcoma

    *Genetics and Immunology of the P815-X2 Model

    *Shed Membrane Vesicles: A Mechanism for Tumor-Induced Immunosuppression

    *Modification of the Induction of BCGcw Suppressor Cells by Mitomycin C1

    *Immunomodulation by a Low Dose of Cyclophosphamide as the Primary Mechanism for the Cure of Mice Bearing a Large Metastatic MOPC-315 Tumor

    *An Immunotherapeutic Model for Murine Transitional Cell Carcinoma

    *Regulation of Human T Cell Responses by Gamma Interferon (IFN-γ): Studies on the Binding and Biological Effects of IFN-γ on Distinct T Cell Subpopulations

    Section 4 Immunotherapy and Biomodulators

    Biomodulation: A Classification and Overview

    Active Specific Immunotherapy with Extracted Tumor-Specific Transplantation Antigens

    Active Specific Immunotherapy as an Adjunct to the Treatment of Metastatic Solid Tumors

    Current Status of Active Non-Specific Immunotherapy

    Adoptive Cellular Immunotherapy

    Thymosins in the Treatment of Cancer

    Restorative Immunotherapy with Interleukin 2

    Staphylococcal Protein A Column: Its Mechanism of Action

    Maturational Factors in Myeloid Leukemia

    *In Vitro and in Vivo Stimulation of Murine Lymphocytes by Human Recombinant Interleukin 2

    *Chemo-Adoptive Immunotherapy of Mice with Established Carcinomas Using Interleukin-2-Propagated Lymphocytes and Crude Lymphokine Preparations

    Section 5 Immunotherapy and Immunoprophylaxis

    Modulation of Immune Functions by Interferons

    Passive Immunotherapy with Monoclonal Antibodies to Differentiation Antigens

    Antibody—Drug and Antibody—Toxin Conjugates

    Antibody—Radioisotope Conjugates for Tumor Localization and Treatment

    Vaccination Against Virally Induced Animal Tumors

    The Biology of Hepatitis B Virus and Hepatocellular Carcinoma

    Chemoimmunotherapy—Strategy Considerations

    Conference Summary

    Index




Product details

  • No. of pages: 678
  • Language: English
  • Copyright: © Academic Press 1985
  • Published: January 28, 1985
  • Imprint: Academic Press
  • eBook ISBN: 9780323143561

About the Editor

Arnold Reif

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