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Immunity to Cancer - 1st Edition - ISBN: 9780125862707, 9780323143561

Immunity to Cancer

1st Edition

Editor: Arnold Reif
eBook ISBN: 9780323143561
Imprint: Academic Press
Published Date: 28th January 1985
Page Count: 678
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Immunity to Cancer documents the proceedings of a conference on ""Immunity to Cancer"" held at Williamsburg, Virginia, September 10-12, 1984. This was the first open conference since the New York Academy of Sciences meeting in 1975 that attempted to address the entire range of topics encompassed by tumor immunology and immunotherapy. The papers presented in this volume were invited from experts in diverse areas of tumor immunology and closely related subjects. There was an attempt to proceed logically from a consideration of the antigenicity of tumors and the use of monoclonal antibodies to examine specific antigens, to a review of regulatory and effector mechanisms. Immunological approaches to therapy were then considered systematically, both for classical modes of immunotherapy and for the newly expanded categories of biological response modifiers or biomodulators. Also included were papers on vaccination against cancer and on the analogy between the strategies for chemotherapy and immunotherapy.

Table of Contents

Senior Authors



Section 1 Identification and Characterization of Tumor Antigens

Some Key Problems for Success of Classical Immunotherapy

What are Tumor Antigens?

Antigenicity of Simian Virus 40 Transformed Cells

Characteristics of Tumor Antigens on Tumors Induced by Chemical Carcinogens: Some Recent Findings

Immunobiology of RAW117 Large Cell Lymphoma

Biochemical and Functional Profiles of Two Unique Melanoma Associated Antigens

Identification and Characterization of Human Leukemia Associated Antigens

Monoclonal Antibodies Against Gastro-Intestinal Tumor Associated Antigens

Immunodiagnosis of Malignancy with Monoclonal Antibodies to Cell Surface Antigens Expressed by Non-Neoplastic Cells

*Human Monoclonal Antibodies that Distinguish Cutaneous Melanomas from Benign Nevi in Fixed Sections

Section 2 Immune Responses to Tumor Antigens

Host Response to Epstein-Barr Virus Infected B Cells

The Role of T Lymphocyte Subsets in the Rejection of 3-Methylcholanthrene Induced Rat Sarcoma Mc7

The Humoral Immune Response to Human Cancer

Relevance of Tumor Model Antigenicities to Human Tumor Immunology

Intensification of Tumor Antigenicity

Effector Cells of T Cell Lineage

Macrophage Effector and Regulatory Functions

Natural Killer (NK) Cells: Characteristics and Possible Role in Resistance Against Tumor Growth

*UV Light-Induced Increase in Immunogenicity of 3LL Tumor Cells

Section 3 Regulation of the Immune Response to Tumor Cells

Suppressor Cells: T Cells and Macrophages

Idiotypes and Anti-Idiotypes

Human T-T Cell Interactions

Lymphokines as Regulators of Tumor Cell Function

Interferons: Cytostatic and Immunomodulatory Effects

Possible Role of Iron Depletion as Cause of Tumor Cell Cytotoxicity Induced by Activated Macrophages

Immunological Surveillance Revisited

AIDS and Kaposi's Sarcoma

*Genetics and Immunology of the P815-X2 Model

*Shed Membrane Vesicles: A Mechanism for Tumor-Induced Immunosuppression

*Modification of the Induction of BCGcw Suppressor Cells by Mitomycin C1

*Immunomodulation by a Low Dose of Cyclophosphamide as the Primary Mechanism for the Cure of Mice Bearing a Large Metastatic MOPC-315 Tumor

*An Immunotherapeutic Model for Murine Transitional Cell Carcinoma

*Regulation of Human T Cell Responses by Gamma Interferon (IFN-γ): Studies on the Binding and Biological Effects of IFN-γ on Distinct T Cell Subpopulations

Section 4 Immunotherapy and Biomodulators

Biomodulation: A Classification and Overview

Active Specific Immunotherapy with Extracted Tumor-Specific Transplantation Antigens

Active Specific Immunotherapy as an Adjunct to the Treatment of Metastatic Solid Tumors

Current Status of Active Non-Specific Immunotherapy

Adoptive Cellular Immunotherapy

Thymosins in the Treatment of Cancer

Restorative Immunotherapy with Interleukin 2

Staphylococcal Protein A Column: Its Mechanism of Action

Maturational Factors in Myeloid Leukemia

*In Vitro and in Vivo Stimulation of Murine Lymphocytes by Human Recombinant Interleukin 2

*Chemo-Adoptive Immunotherapy of Mice with Established Carcinomas Using Interleukin-2-Propagated Lymphocytes and Crude Lymphokine Preparations

Section 5 Immunotherapy and Immunoprophylaxis

Modulation of Immune Functions by Interferons

Passive Immunotherapy with Monoclonal Antibodies to Differentiation Antigens

Antibody—Drug and Antibody—Toxin Conjugates

Antibody—Radioisotope Conjugates for Tumor Localization and Treatment

Vaccination Against Virally Induced Animal Tumors

The Biology of Hepatitis B Virus and Hepatocellular Carcinoma

Chemoimmunotherapy—Strategy Considerations

Conference Summary



No. of pages:
© Academic Press 1985
28th January 1985
Academic Press
eBook ISBN:

About the Editor

Arnold Reif

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