Imidazole-Based Drug Discovery

Imidazole-Based Drug Discovery

1st Edition - December 2, 2021

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  • Author: Shikha Agarwal
  • eBook ISBN: 9780323903639
  • Paperback ISBN: 9780323854795

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Description

Imidazole-Based Drug Discovery covers all categories of imidazole and its derivatives, synthesis, pharmacological applications and drug-based studies. Imidazole scaffolds act as a channel between organic synthesis and medicinal chemistry and compel researchers to explore new drug candidates. This book provides detailed coverage of several greener synthetic protocols and pharmacological applications of imidazole derivatives that are useful to researchers working on designing more promising clinical lead compounds with this scaffold. It also includes information on past decades of research on the synthesis and biological applications of imidazole derivatives. This is an ideal resource for researchers in organic chemistry both in academic and industrial settings, as well as postgraduates in chemistry and medicinal chemistry.

Key Features

  • Reviews the most current developments and future perspectives of imidazole on different disease therapies to achieve the ultimate goal of disease eradication
  • Discusses the role of imidazole in contemporary science, technological innovation, drug development, critical challenges and future research directions
  • Covers emerging trends on different eco-benign pathways to synthesize imidazole derivatives for the development of simpler synthetic protocols

Readership

Researchers in organic chemistry both in academic and industrial settings, postgraduates in chemistry and medicinal chemistry. Researchers in pharmaceutical industries, chemical and pesticide industries

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • Contributors
  • About the authors
  • Preface
  • Acknowledgments
  • Chapter 1: Imidazole and its derivatives: Introduction and synthetic aspects
  • Abstract
  • 1: Introduction
  • 2: Synthesis of substituted imidazoles
  • 3: Imidazole hybrids
  • 4: Benzimidazole
  • 5: Conclusion
  • Conflict of interest
  • Acknowledgments
  • Funding source
  • References
  • Chapter 2: Biological profile of imidazole-based compounds as anticancer agents
  • Abstract
  • 1: Introduction
  • 2: Imidazole-based heterocycles
  • 3: Conclusion and future challenges
  • References
  • Chapter 3: Recent advancements on imidazole containing heterocycles as antitubercular agents
  • Abstract
  • 1: Introduction
  • 2: Imidazole-based heterocycles
  • 3: Conclusion
  • References
  • Chapter 4: Imidazole derivatives: Impact and prospects in antiviral drug discovery
  • Abstract
  • 1: Introduction
  • 2: Imidazole derivatives and their action against different viruses
  • 3: Conclusion
  • References
  • Chapter 5: Imidazole heterocycles: Therapeutically potent lead compounds as antimicrobials
  • Abstract
  • 1: Introduction
  • 2: Imidazole-based antimicrobial compounds
  • 3: Conclusion and future perspectives
  • References
  • Chapter 6: Imidazole containing heterocycles as antioxidants
  • Abstract
  • 1: Introduction
  • 2: Imidazole-based antioxidant compounds
  • 3: Conclusion and future perspectives
  • References
  • Chapter 7: Miscellaneous biological activity profile of imidazole-based compounds: An aspirational goal for medicinal chemistry
  • Abstract
  • 1: Introduction
  • 2: Imidazole-based bioactive compounds
  • 3: Conclusion and future perspectives
  • References
  • Chapter 8: Imidazole-based drugs and drug discovery: Present and future perspectives
  • Abstract
  • 1: Introduction
  • 2: Imidazole-based market available drugs
  • 3: Pharmacokinetics and pharmacodynamic profiles of a drug
  • 4: Synergy between imidazole-based compounds and drug development
  • 5: Conclusion and future prospects
  • References
  • Further reading
  • Index

Product details

  • No. of pages: 372
  • Language: English
  • Copyright: © Elsevier 2021
  • Published: December 2, 2021
  • Imprint: Elsevier
  • eBook ISBN: 9780323903639
  • Paperback ISBN: 9780323854795

About the Author

Shikha Agarwal

Dr. Shikha Agarwal has been Assistant Professor in the Department of Chemistry, Mohanlal Sukhadia University, Udaipur since 2012. She received the Gold Medal in MSc Chemistry in 2006 from the University of Rajasthan, Jaipur, and was a recipient of JRF and SRF from CSIR, New Delhi and qualified GATE-2006 in the 98th percentile. She was awarded a PhD from the University of Rajasthan, Jaipur in 2011. Dr. Agarwal has published more than 50 research articles in various national and international journals, and has published several books and contributed chapters. Her research interests are in synthetic organic chemistry, green chemistry, catalysis, and combinatorial and medicinal chemistry.

Affiliations and Expertise

Department of Chemistry, University College of Science, Mohanlal Sukhadia University, Rajasthan, Udaipur, India

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