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Section 1: Imaging Applications in Atypical Parkinsonism
1. PET Molecular Imaging in Atypical Parkinsonism
Zheyu Xu, Javier Arbizu and Nicola Pavese
2. SPECT Molecular Imaging in Atypical Parkinsonism
Joachim Brumberg and Ioannis U. Isaias
3. Structural Imaging in Atypical Parkinsonism
Beatrice Heim, Florian Krismer and Klaus Seppi
4. Functional MRI in Atypical Parkinsonisms
Federica Agosta, Elisabetta Sarasso and Massimo Filippi
Section 2: Imaging Applications in Familial Movement Disorders
5. PET Molecular Imaging in Familial Parkinson's Disease
Michele Matarazzo, Daryl Wile, Melissa Mackenzie and A. Jon Stoessl
6. SPECT Molecular Imaging in Familial Parkinson's Disease
Andrea Varrone and Maria Teresa Pellecchia
7. Structural and Functional MRI in Familial Parkinson’s Disease
8. Molecular Imaging in Huntington's Disease
Heather Wilson and Marios Politis
9. Structural Magnetic Resonance Imaging in Huntington’s Disease
Heather Wilson, George Dervenoulas and Marios Politis
10. Functional Magnetic Resonance Imaging in Huntington’s Disease
Sarah Gregory and Rachael I. Scahill
Imaging in Movement Disorders: Imaging in Atypical Parkinsonism and Familial Movement Disorders, Volume 142, addresses the use of imaging modalities across the spectrum of movement disorders and dementias. Over the last decades, advances in neuroimaging tools have played a pivotal role in expanding our understanding of disease aetiology and pathophysiology, identifying biomarkers to monitor disease progression, aiding differential diagnosis and in the identification of novel targets for therapeutic intervention. This updated volume covers PET Molecular Imaging in Atypical Parkinsonism, SPECT Molecular Imaging in Atypical Parkinsonism, Structural MRI in Atypical Parkinsonism, Functional MRI in Atypical Parkinsonism, and more.
- Offers a complete review of the applications of neuroimaging tools in Atypical Parkinsonism, familial Parkinson’s disease and Huntington’s disease
- Discusses the role of neuroimaging modalities, including SPECT, PET, and structural and functional MRI
- Includes sections on potential clinical applications and future directions
Specialists in Movement Disorders, Trainees in Movement Disorders, Neurologists, Researchers, Neuroimaging and Neuroscience Scientists, Medical Students, Universities
- No. of pages:
- © Academic Press 2018
- 9th November 2018
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
Professor Marios Politis (MD MSc DIC PhD FRCP FEAN) is a Professor of Neurology & Neuroimaging, Consultant Neurologist, and the Director of Neurodegeneration Imaging Group at King’s College London and King’s College Hospital. He is a Visiting Professor at University of Exeter Medical School. His research involves the use of molecular (PET), functional (fMRI) and structural imaging as a method of investigating aetiology, pathophysiology, and effects and complications of novel therapies in Neurodegenerative disorders. His high-quality research has led to a body of scientific work investigating the pathophysiology of movement disorders such as Parkinson’s and Huntington’s disease and to publications in high impact scientific journals including Nature, Lancet, and Science journals, and also in the Journal of Clinical Investigation, Annals of Neurology, Brain, Neurology and JAMA Neurology. Professor Politis is a recipient of fellowships from and grant project awards from the Michael J Fox Foundation for Parkinson’s research, CHDI Foundation, Medical Research Council, European Union, Lily and Edmond J. Safra Foundation, Parkinson’s UK, National Institute of Health Research UK, Biomedical Research Centre UK and Alzheimer’s Disease Association UK. Professor Politis graduated in Medicine from the University of Athens, Greece, and he obtained an MSc and the Diploma of Imperial College in Integrative Neuroscience. He holds a PhD in Clinical Neuroscience from Imperial College London. He has previously worked as a clinical research fellow at University College London (UCL) and Imperial College London. He is a former Research Investigator of Hammersmith’s’ Cyclotron PET Unit. Before moving to King’s College London, he was an Academic Principal Investigator in the Neurology Imaging Unit at Imperial College London. He has significant industry experience by serving as a clinical investigator, consultant and principal investigator in several collaborations with industrial partners and pharma including a number of clinical trials. He has achieved a high number of awards and distinctions including the Movement Disorder Society Award for Outstanding and Innovative Clinical Research in 2012. In 2010, his PET imaging work in transplantation of foetal ventral mesencephalic tissue in Parkinson’s Disease patients was classed as one of the most important research achievements of MRC-funded research. He has received for four years in a row (2013-2016) the IMPETus award for innovative and outstanding PET molecular imaging research. In 2015, he received the PET Investigator Award from the Society of Nuclear Medicine and Molecular Imaging. In 2016, he was elected as Fellow of the European Academy of Neurology for outstanding contribution in neurodegenerative research. In 2017, he received the Jon Stolk Award in Movement Disorders from the American Academy of Neurology, and was elected Fellow of Royal College of Physicians. Professor Politis serves in the Scientific Advisory Board for the Movement Disorders Society, World Congress on Controversies in Neurology, the International Congress on Vascular Dementia, the International Congress on Non-Motor Dysfunctions in Parkinson's Disease and Related Disorders, Neurodegenerative Disease Research European Union Imaging committee, the Norwegian funding for Dementia, the Michael J Fox Foundation neuroinflammation consortium for Parkinson’s disease, the Alzheimer’s Research UK Network, and the Scientific Oversight Panel of the State University of New York. Professor Politis is a scientific advisor to the French National Research Agency (ANR), Medical Research Council (MRC) UK, Alzheimer’s Research UK, Parkinson’s UK, European Union, Canada Foundation for Innovation, Israel Science Foundation, Swiss National Science Foundation, National Research Foundation (NRF) in Korea, Research Grants Council (RGC) in Hong Kong, Austrian Science Fund, Geneva University Hospitals Research Fund, Michael J Fox Foundation (MJFF) for Parkinson’s research, and a scientific advisory board member of the Network of European CNS Transplantation and Restoration (NECTAR), and was previously member of the European Parkinson’s transplantation trial development group (TRANSEURO). He is an active member of American Academy of Neurology, Movement Disorder Society, British Neuroscience Association, MJFF neuroinflammation consortium, Neurodegenerative Disease Research (JPND) Imaging committee, MDS Neuroimaging Study Group, MDS Non-Motor Study Group, and a Fellow of Royal Society of Medicine. Professor Politis is an Associate Editor for Frontiers in Neurology and Nature Parkinson’s Journal. At King’s College London, he teaches undergraduate and postgraduate students Neurology, Neuroimaging and Neuroscience.
Director, Neurodegeneration Imaging Group, Professor in Neurology and Neuroimaging, Consultant Neurologist, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London and King’s Health Partners
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