Idiotypes documents the proceedings of an International Conference on Idiotypes held in Oklahoma City, Oklahoma, at the Oklahoma Medical Research Foundation, October 20-23, 1985. The aims of the conference were to gather active investigators in the study of idiotypes; to assess progress in the field; and to explore directions for future research.
The papers presented at the conference cover a wide range of subjects. Several papers deal with defining protein and DNA sequences which determine idiotypes. Evidence points to germ line genes encoding the V region structures which underlie idiotypy. Another subtheme which concerns several contributions is the occurrence of dominant idiotypes in induced immune responses (e.g., arsonate and lysozyme) and autoimmunity (e.g., thyroglobulin and rheumatoid factors). The presence of such dominant idiotypes is discussed from several viewpoints, but the recurrent theme is that such dominance is a manifestation of a selection process inherent in the idiotypic network. Two papers deal with idiotypic structures in T cells: on the one hand, identifying idiotypes on T helper cells and, on the other, I-J and Iat related structures which tightly govern cellular interactions in the evolution of an immune response. Network interactions through autoanti-idiotypic responses are shown to be associated with the effects on the specificity of both induced and naturally occurring immune responses. Autoanti-idiotypic responses are also shown to be correlated with the regulation of the anti-DNA response in human systemic lupus erythematosus. These data pointed to a role of the idiotype network in immune regulation.
Preface I. Structure-Function Relationships in Idiotypes The GAT System: A Possible Germ Line Idiotypic Network The Germ Line VH and DH Gene Segments Encoding the Ars A Family of Anti-Arsonate Antibodies Generation of Antibody Diversity in the PC-Specific Immune Response to Proteus morganii II. Auto-Anti-Idiotypes and Regulation of the Immune Response Regulation of Antibody Clones in Rabbits by Auto-Anti-Idiotype A Regulatory Idiotype on Autoantibodies Idiotype Network Regulation: Analysis of Mechanisms Using a Plasmacytoma Model Regulation of Anti-DNA Antibodies by Anti-Idiotypic Antibodies in Sera of Families of Lupus Patients III. Internal Images and the Immune Network From Idiotypes to Idiotypic Networks Idiotypy of β-Adrenergic Ligand Binding Antibodies and Receptors The Auto-Anti-Idiotypic Route to Anti-Receptor Antibodies On the Mechanism of Internal Image Vaccines IV. Regulation, Restrictive Elements, and the Repertoire A Tale of Two Idiotypes: Different Predominant Idiotypes in the Primary and Secondary Responses to Hen Eggwhite Lysozyme The Influence of VH and Vk Polymorphism on the Expression of the Selected and Preimmune Repertoire Idiotypic Immunoregulation: Interclonal Connections Based on a Special Category of Idiotypes The Immune Circuit: Somatic Generation of Epitopes Involved in the Mutual Recognition by Different Subsets of T Cells Idiotype Sharing between B and T Lymphocytes Reflects Autonomous Self-Responses within the Immune System V. Idiotypes on Autoantibodies Origins of Anti-DNA Antibodies Idiotypic Analysis of Murine Monoclonal Anti-Sm Antibodies Idiotype Regulation and Rheumatoid Factors VI. A Comparison of Network Theory and Associative Recognition Idiotype Network Views of Immune Regulation: For Whom the Bell Tolls Index
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- © Academic Press 1986
- 28th January 1986
- Academic Press
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