Idiotypes and Lymphocytes

Idiotypes and Lymphocytes

1st Edition - January 1, 1981

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  • Author: Constantin Bona
  • eBook ISBN: 9780323159760

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Idiotypes and Lymphocytes reviews the progress made in the study of the idiotypes of lymphocytes, particularly the discovery that a vast spectrum of possible relationships between cells and antibodies and communications between various subsets of T- and B-lymphocytes exist within the immune system. The book explores autoanti-idiotype antibodies and the antigen-mimicking properties of anti-idiotype antibodies, along with the idiotypic determinants borne by the lymphocyte’s receptor that serve as regulatory sites. Organized into seven chapters, this volume begins with an overview of idiotypy, from its discovery to the localization of idiotypic determinants in the variable regions. This book also explains how idiotypic specificity is associated with a particular antigenic specificity of the antibody molecule, the diversity of antibodies, and the regulation of the immune response. The next chapters introduce the reader to the ontogeny of idiotypic expression, touching on topics such as the development of B cells and sequential activation of V genes, along with the variability of idiotypic specificities during immune response. The book also explores the expression of idiotypes in B-lymphocytes and of idiotypic determinants of humoral antibodies in the antigenic receptors of T cells, as well as the mechanisms that allow anti-idiotype antibodies to regulate lymphocyte functions. The final chapter looks into the therapeutic implications of the immune network, with emphasis on the effects of anti-idiotypes antibodies in autoimmune diseases. This book is an essential reading for immunologists.

Table of Contents

  • Preface

    1 Idiotypy—General Features

    I. Introduction

    II. Anti-idiotypic Sera

    III. Individual and Cross-Reactive Idiotypes

    IV. Triple Relationship between Combining Site, Hypervariable Region, and Idiotypes

    V. VH-VL Idiotypic Determinants

    VI. Polymorphism of Idiotypes

    VII. Genetics of Idiotypes

    VIII. Control of Expression of the Silent Idiotypic Repertoire

    2 Ontogeny of Expression of Idiotypes

    I. Scheme of Development of B Cells

    II. Expression of Idiotypic Determinants in Pre-B Cells

    III. Sequential Activation of V Genes

    IV. Maternal Idiotype Suppression

    V. Neonatal Idiotype Suppression

    3 Variation of Idiotypes during the Immune Response

    I. Persistance and Variation of Idiotypes during the Immune Response

    II. Inverse Fluctuation between Idiotype-Bearing Antibodies and Spontaneous Occurrence of Anti-idiotypic Antibodies

    4 Expression of Idiotypes on B Cells

    I. Expression of Idiotypes on Ig Receptor of B Cells

    II. Dependence of Expression of Idiotypes on Site of Localization of Lymphocytes within Lymphoid Tissue and B Lymphocyte Subsets

    III. Activation of Precursors of Antibody-Forming Cells by Anti-idiotypic Antibodies

    IV. T-Independent Idiotype Suppression

    V. Idiotype Suppression Mediated by Cells (B Cell Dominance)

    VI. In Vitro Idiotypic Suppression of Secretion of Ig by Leukemic Cells

    VII. Inhibition of Growth of Myeloma Cells by Anti-idiotypic Antibodies

    5 Idiotypic Determinants and T

    I. Introduction

    II. V Region Expressed on the Antigen-Binding Receptor of T Cells

    III. Idiotypic Determinants on the Effector T Cells

    IV. Idiotypic Determinants on Helper T Cells

    V. Idiotypic Determinants on Suppressor T Cells

    VI. T Cell-Mediated Idiotype Suppression of Synthesis of Antibodies

    VII. Unresponsiveness of T Cells Induced by Anti-Id Antibodies

    6 Immune Network: Regulation of Lymphocyte Functions by Anti-idiotype Antibodies

    I. Network Concept

    II. Demonstration of Formal Network

    III. From Formal Network to Functional Network

    IV. Suppressive Types of Networks

    V. Enhancing Type of Network

    7 Physiological and Pathological Implications of the Immune Network

    I. Modulation of Functions of Nonlymphoid Somatic Cells by Antibodies

    II. Mimicry of Hormone and Vitamin Properties by Anti-Id Antibodies

    III. Autoimmune Anti-Receptor Diseases

    IV. Effects of Anti-Id Antibodies in Autoimmune Diseases



Product details

  • No. of pages: 226
  • Language: English
  • Copyright: © Academic Press 1981
  • Published: January 1, 1981
  • Imprint: Academic Press
  • eBook ISBN: 9780323159760

About the Author

Constantin Bona

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