Idiotypes and Lymphocytes

1st Edition - January 1, 1981
Author: Constantin Bona
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 5 9 7 6 - 0

Idiotypes and Lymphocytes reviews the progress made in the study of the idiotypes of lymphocytes, particularly the discovery that a vast spectrum of possible relationships between… Read more

Purchase options

LIMITED OFFER

Save 50% on book bundles

Immediately download your ebook while waiting for your print delivery. No promo code is needed.

Institutional subscription on ScienceDirect

Request a sales quote

Idiotypes and Lymphocytes reviews the progress made in the study of the idiotypes of lymphocytes, particularly the discovery that a vast spectrum of possible relationships between cells and antibodies and communications between various subsets of T- and B-lymphocytes exist within the immune system. The book explores autoanti-idiotype antibodies and the antigen-mimicking properties of anti-idiotype antibodies, along with the idiotypic determinants borne by the lymphocyte’s receptor that serve as regulatory sites. Organized into seven chapters, this volume begins with an overview of idiotypy, from its discovery to the localization of idiotypic determinants in the variable regions. This book also explains how idiotypic specificity is associated with a particular antigenic specificity of the antibody molecule, the diversity of antibodies, and the regulation of the immune response. The next chapters introduce the reader to the ontogeny of idiotypic expression, touching on topics such as the development of B cells and sequential activation of V genes, along with the variability of idiotypic specificities during immune response. The book also explores the expression of idiotypes in B-lymphocytes and of idiotypic determinants of humoral antibodies in the antigenic receptors of T cells, as well as the mechanisms that allow anti-idiotype antibodies to regulate lymphocyte functions. The final chapter looks into the therapeutic implications of the immune network, with emphasis on the effects of anti-idiotypes antibodies in autoimmune diseases. This book is an essential reading for immunologists.

Preface

1 Idiotypy—General Features

I. Introduction

II. Anti-idiotypic Sera

III. Individual and Cross-Reactive Idiotypes

IV. Triple Relationship between Combining Site, Hypervariable Region, and Idiotypes

V. VH-VL Idiotypic Determinants

VI. Polymorphism of Idiotypes

VII. Genetics of Idiotypes

VIII. Control of Expression of the Silent Idiotypic Repertoire

2 Ontogeny of Expression of Idiotypes

I. Scheme of Development of B Cells

II. Expression of Idiotypic Determinants in Pre-B Cells

III. Sequential Activation of V Genes

IV. Maternal Idiotype Suppression

V. Neonatal Idiotype Suppression

3 Variation of Idiotypes during the Immune Response

I. Persistance and Variation of Idiotypes during the Immune Response

II. Inverse Fluctuation between Idiotype-Bearing Antibodies and Spontaneous Occurrence of Anti-idiotypic Antibodies

4 Expression of Idiotypes on B Cells

I. Expression of Idiotypes on Ig Receptor of B Cells

II. Dependence of Expression of Idiotypes on Site of Localization of Lymphocytes within Lymphoid Tissue and B Lymphocyte Subsets

III. Activation of Precursors of Antibody-Forming Cells by Anti-idiotypic Antibodies

IV. T-Independent Idiotype Suppression

V. Idiotype Suppression Mediated by Cells (B Cell Dominance)

VI. In Vitro Idiotypic Suppression of Secretion of Ig by Leukemic Cells

VII. Inhibition of Growth of Myeloma Cells by Anti-idiotypic Antibodies

5 Idiotypic Determinants and T

I. Introduction

II. V Region Expressed on the Antigen-Binding Receptor of T Cells

III. Idiotypic Determinants on the Effector T Cells

IV. Idiotypic Determinants on Helper T Cells

V. Idiotypic Determinants on Suppressor T Cells

VI. T Cell-Mediated Idiotype Suppression of Synthesis of Antibodies

VII. Unresponsiveness of T Cells Induced by Anti-Id Antibodies

6 Immune Network: Regulation of Lymphocyte Functions by Anti-idiotype Antibodies

I. Network Concept

II. Demonstration of Formal Network

III. From Formal Network to Functional Network

IV. Suppressive Types of Networks

V. Enhancing Type of Network

7 Physiological and Pathological Implications of the Immune Network

I. Modulation of Functions of Nonlymphoid Somatic Cells by Antibodies

II. Mimicry of Hormone and Vitamin Properties by Anti-Id Antibodies

III. Autoimmune Anti-Receptor Diseases

IV. Effects of Anti-Id Antibodies in Autoimmune Diseases

References

Index