The International Summer School of Brain Research, on which this book is based, was organized by the Netherlands Institute for Brain research (NIBR), which has a rich history dating back to the beginning of the century.

The focus of interest in this present volume of Progress in Brain Research are the few thousand neurons at the base of the hypothalamus that form the biological clock. Attention is focused on the mechanisms underlying the generation of circadian rhythmicity within our biological clock, which is still far from understood. Contributions originating from many disciplines give updates on the latest theories on the molecular and electrophysiological basis of the pacemaker mechanism, and the various approaches used in different species. Attention is also paid to the way the signal of the biological clock is transferred to the rest of the central nervous system. New data on the role of the suprachiasmatic nucleus and its impact on the functioning of the human being is presented. Altogether an excellent volume which will further the understanding of this elusive material.

Table of Contents

List of Contributors. Preface. Acknowledgements. Section I. Molecular and Cellular Mechanisms of Circadian Pacemakers. The sixth C.U. Ariëns Kappers lecture. 1. The biological clock: it's all in the genes (J.S. Takahashi). 2. The genetic and molecular dissection of a prototypic circadian system (J.C. Dunlap et al). 3. The Drosophila genes timeless and period collaborate to promote cycles of gene expression composing a circadian pacemaker (M.W. Young). 4. Excitatory and inhibitory amino acids and synaptic transmission in the suprachiasmatic nucleus (A.N. van den Pol, G.J. Strecker, F.E. Dudek). 5. Astrocytes in the mammalian circadian clock: putative roles (J. Servière, M. Lavialle). 6. Circadian rhythms of neuropeptides in the suprachiasmatic nucleus (S.-I.T. Inouye). Section II. Entrainment of the Circadian Timing System. 7. Circadian rhythm generation, expression and entrainment in a molluscan model system (G.D. Block et al.). 8. Entrainment pathways and the functional organization of the circadian system (R.Y. Moore). 9. Regulation of entrainment pathways by the suprachiasmatic circadian clock: sensitivities to second messengers (M.U. Gillette). 10. Light entrainment and activation of signal transduction pathways in the SCN (J.M. Kornhauser et al.). 11. Entrainment of the circadian clock (M.H. Hastings et al.). 12. Light entrainment of the mammalian biological clock (J.H. Meijer et al.). 13. Regulation and integration in the mammalian circadian system (M.R. Ralph et al.). 14. The role of melatonin and light in the human circadian system (A.J. Lewy, R.L. Sack). 15. Perinatal development of human circadian rhythms (M. Mirmiran, S. Lunshof). Section III. Hypothalamic Integration of Circadian Rhythms. 16. The anatomical basis for the expression of circadian rhythms: the efferent projections of the suprachiasmatic nucleus (R.M. Buijs). 17. Electrophysiology of suprachiasmatic nuc


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© 1996
Elsevier Science
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About the editors

R.M. Buijs

Affiliations and Expertise

Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands

A. Kalsbeek

Affiliations and Expertise

The Netherlands Institute for Brain Research, Amsterdam, The Netherlands

M. Mirmiran

Affiliations and Expertise

Netherlands Institute for Brain Research

C.M.A. Pennartz

Affiliations and Expertise

Netherlands Institute for Brain Research, Amsterdam, The Netherlands