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Hyaluronan - 1st Edition - ISBN: 9781855735705, 9781845693121


1st Edition

Proceedings of an International Meeting, September 2000, North East Wales Institute, UK

Editors: J F Kennedy G O Phillips P A Williams V C Hascall
eBook ISBN: 9781845693121
Hardcover ISBN: 9781855735705
Imprint: Woodhead Publishing
Published Date: 4th October 2002
Page Count: 1152
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Table of Contents

Volume 1: Chemistry, biochemistry and cell biology – Overview of the history and development of hyaluronan; Characterization and solution properties of hyaluronan; Rheological behaviour of hyaluronan; Biosynthesis and biological degradation of hyaluronan; Novel modified forms of hyaluronan; Cell surfaces and hyaluronan receptors; The action of hyaluronan in cells; Keratinocytes and hyaluronan.Volume 2: Biomedical, medical and clinical aspects – Adhesion formation and hyaluronan; Application of hyaluronan in tissue engineering; The function and use of hyaluronan in wound healing; The role of hyaluronan in tissues; The use of hyaluronan in drug delivery; Aspects of hyaluronan in joints; Clinical applications of hyaluronan.


Hyaluronan and its derivatives has developed very quickly in the last few years from a scientific novelty into an important new material for a diverse range of medical and biomaterial applications. This landmark conference focused on developments and applications in the use of hyaluronan in tissue repair and reconstruction, drug delivery systems, anti-cancer treatments and joint recovery and engineering.
The entire range of hyaluronan progress is covered in depth by the more than 135 individual papers:

Analytical chemistry
Structural elucidation and basic chemistry
Electron microscopy and atomic force microscopy
Production, purification and characterisation
Quality in production systems

Chemical modification
Derivatives and properties
Free radical modification

Physical characterisation

Aggregation phenomena
Interaction with water and solution properties

Cell biology

Control and regulation of HA synthases
Cell surface chemistry
HA cell receptors and cell signalling
Interaction with proteins and other biological ligands
Biophysical aspects
Effects on pain receptors
Role in organisation of extracellular matrix
Role in development (embryogenesis): cell movement/migration

Medical applications

Uses in cartilage and wound repair
Wound regenerative healing
Surgery and tissue engineering
Viscosupplementation / osteoarthritis
Viscoaugmentation and viscoprotection
Anti-adhesion applications
Brug delivery systems
Binding onto tumour cells and metastases

Key Features

  • Outlines the proceedings of the landmark conference which focused on key developments and applications in the use of hyaluronan in tissue repair and reconstruction, among other uses
  • The entire range of hyaluronan processes is dealt with in depth by more than 135 individual papers presented in two volumes
  • Covers analytical chemistry, chemical modification, physical characterisation, cell biology and medical applications


Academics, materials researchers, materials engineers, clinicians, and other professionals concerned with biomaterials


No. of pages:
© Woodhead Publishing 2002
4th October 2002
Woodhead Publishing
eBook ISBN:
Hardcover ISBN:

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About the Editors

J F Kennedy

John F. Kennedy is Director of the Birmingham Carbohydrate and Protein Tehcnology Group, School of Chemistry, University of Birmingham. He is Director of Chembiotech laboratories and is also Professor of Applied Chemistry at The North East Wales Institute of higher Education (NEWI). He is a Fellow of the Royal Society of Chemistry, the Institute of Management, the Institute of Food Science and Technology and the Institute of Biology. He is also editor of the journal, Carbohydrate Polymers.

Affiliations and Expertise

University of Birmingham

G O Phillips

Professor Glyn O. Phillips was Professor of Chemistry at the University of Salford and appointed as Executive Principal of the North East Wales Institute (now Wrexham Glyndwr University) in 1976. He is a Fellow of the Learned Society of Wales and was awarded an honorary degree of Doctor of Science by the University of Benin in 1990 and an honorary degree of Doctor of Laws by the University of Wales in 1999. He was awarded the A.G. Evans Medal by the University of Cardiff in 1991, the first Science and Technology Medal by the National Eisteddfod of Wales in 2004 and the Food Hydrocolloids Trust Medal in 2007. He has a broad range of scientific interests and has published more than 600 research papers in areas including radiation and free radical chemistry, radiation sterilisation, photochemistry and carbohydrate and polysaccharide chemistry. He was technical adviser to the International Atomic Energy Agency and editor of the journals, Food Hydrocolloids, Advances in Tissue Banking and International Journal of Cell and Tissue banking. He initiated the Gums and Stabilisers for the Food industry series of Conferences in 1981 and established the Phillips Hydrocolloids Research Centre at Wrexham Glyndwr University in 2003.

Affiliations and Expertise

Chairman, Phillips Hydrocolloid Research Ltd, UK

P A Williams

Peter A. Williams is Professor of Polymer and Colloid Chemistry and Director of the Centre for Water Soluble Polymers at Wrexham Glyndwr University. He was awarded the degree of Doctor of Philosophy by the University of Salford in 1982 and Doctor of Science in 2009. He is a Fellow of the Royal Society of Chemistry and a Chartered Chemist. He has over 35 years research experience in the chemical modification, physicochemical characterisation, rheological properties and interfacial behaviour of hydrocolloids. He has published over 230 research papers and edited 42 books. He is co-founder and Editor-in-Chief of the international journal Food Hydrocolloids which was launched in 1986. He has been involved in the organisation of more than 40 international conferences on behalf of the Food Hydrocolloids Trust, the Cellucon Trust the Royal Society of Chemistry and the Society of Chemical Industry. He is a past Chairman of the Society of Chemical Industry Surface and Colloids Group and past Treasurer of the Royal Society of Chemistry Colloid and Interface Science Group. He was awarded the SCI Distinguished Service award in 2007 and the Food Hydrocollloids Trust Medal in 2013.

Affiliations and Expertise

Professor of Polymer and Colloid Chemistry, and Director of the Centre for Water Soluble Polymers at Wrexham Glyndwr University

V C Hascall

Affiliations and Expertise

Lerner Research Institute, USA