Humoral Factors in Host Defense

Humoral Factors in Host Defense

1st Edition - January 1, 1983

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  • Editor: Yuichi Yamamura
  • eBook ISBN: 9780323153119

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Humoral Factors in Host Defense contains the proceedings of the First Takeda Science Foundation Symposium on Bioscience, held on October 28-30, 1982, in Kyoto, Japan. The symposium focused on the humoral factors regulating immune responses, with emphasis on T cell-derived immunoregulatory molecules; molecular mechanisms of interferons; factors involved in differentiation and activation of immunocytes; and the use of the molecular genetics approach to host defense factors. Organized into four parts encompassing 22 chapters, this volume begins with an overview of interleukin-2 and T cell-replacing factors, along with their immunological functions and biochemical features. It then discusses antigen-specific T cell factors; immunoregulatory molecules from human monoclonal T cells; physiological and pathological roles of lymphokines; regulation of the immune system by monoclonal T cell peptides; production of a glycosylated human protein by recombinant DNA technology; and molecular genetics of immunoglobulin genes and the major histocompatibility antigen. Geneticists and biologists will find this book extremely useful.

Table of Contents

  • Contributors



    T Cell-Derived Immunoregulatory Molecules

    1. Immunological Functions and Biochemical Characterizations of IL-2 and T Cell-Replacing Factors

    Immunological Function and Biological Characterization of T Cell-Replacing Factor and Its Acceptor Site(s) on B Cells

    The Hormonal Basis for T Cell Growth

    B Cell Activation

    2. Antigen Specific T Cell Factors

    Control of the Immune System by Monoclonal T Cell Peptides

    An Antigen-Specific Suppressor Ô Cell Factor Composed of Two Distinct Polypeptide Chains

    3. Immunoregulatory Molecules from Human Monoclonal T Cells

    Immunoregulation of Human B Lymphocyte Function by Products of Hybridized and Cloned T Cells

    Regulation of Proliferation and Differentiation of B Lymphocytes by T Cell-Derived Immunoregulatory Molecules


    1. Interferon Genes

    Production of a Glycosylated Human Protein by Recombinant DNA Technology

    Expression of the Human Interferon-âé Gene in Heterologous Host Cells

    2. Molecular Mechanisms of Interferon Action

    Interferon Action and the Role of 2-5A

    Interferon Action: (A) Interferons as Inducers of mRNA and Protein Synthesis (B) Cross-Linking of Mouse-Beta Interferon to Cell Surface Receptors

    3. Purification and Molecular Properties

    Characterization of Mouse Interferon Molecules

    The Human Interferons: Their Purification and Sequence, Cloning and Expression in Bacteria, and Biological Properties

    Factors Involved in Differentiation and Activation of Immunocytes

    Physiological and Pathological Roles of Lymphokines

    The Function and Regulation of Macrophages Bearing I-Region-Associated Molecules

    A Current View of Interleukin I

    Characterization of Three Human Migration Inhibitory Factors (MIF) and Their Specific Production by Different Antigens

    Lymphokine-Producing Human T Cell Hybridomas

    Molecular Genetic Approach to Host Defense Factors

    1. Molecular Genetics of Immunoglobulin Genes

    Immunoglobulin Lambda Genes: Structure, Evolution, and Expression

    Human Immunoglobulin Genes

    2. Molecular Genetics of Major Histocompatibility Antigen

    Class II Genes of the Major Histocompatibility Complex in Mice

    HLA-DR Region Proteins and Genes


Product details

  • No. of pages: 382
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: January 1, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9780323153119

About the Editor

Yuichi Yamamura

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