Human Microbiota in Health and Disease - 1st Edition - ISBN: 9780128146491

Human Microbiota in Health and Disease

1st Edition

From Pathogenesis to Therapy

Authors: Bryan Tungland
Paperback ISBN: 9780128146491
Imprint: Academic Press
Published Date: 1st July 2018
Page Count: 680
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Human Gut Microbiota in Health and Disease: From Pathogenesis to Therapy is a comprehensive discussion on all the aspects associated with the early colonization of gut microbiota, its development and maintenance, and its symbiotic relationship with the host in promoting health. Chapters illustrate the complex mechanisms and metabolic signaling pathways related to how the gut microbiota maintain proper regulation of glucose, lipid and energy homeostasis and immune response, all while mediating inflammatory processes involved in the etiology of many chronic disease conditions.

With today's common use of pharmaceutical medicine in treating symptoms and frequent overuse of antibiotics in chronic disease within mainstream medical practice, our understanding of the etiological mechanisms of dysbiosis-induced chronic disease and natural approaches to prevention and potential cures for these diseases is of vital importance to overall human health.

Key Features

  • Details the complex relationship between human microbiota in the gut, oral cavity and skin as well as their colonization, development and impact of factors that influence the relationship
  • Illustrates the mechanisms associated with dysbiosis-associated inflammation and its role in the onset and progression in chronic disease
  • Provides the primary mechanisms and comprehensive scientific evidence for the use of dietary modification and pro- and prebiotics in preventing chronic disease


Biomedical researchers who focus on understanding the complex mechanisms and metabolic signalling pathways related to how the gut microbiota maintain proper regulation; gastroenterologists and professionals of the functional foods industry

Table of Contents

1. Gut Microbiota, Early Colonization and Factors in its Development that Influence Health
2. Microbiota Short Chain Fatty Acid (Scfa) Production and Host Metabolism
3. Gut Microbiota Influence Bile Acid Metabolism to Effect Lipid and Glucose Metabolism, Energy Homeostasis and Inflammation
4. Role of Gut Microbiota in Immune Homeostasis
5. Direct Physiological Effects on Local Gi Function and Indirect Systemic Effects of Prebiotic Fructan Treatment and Its Role in Disease Prevention and Therapy
6. Immune and Physiological Impairment and Intestinal-Based Diseases Associated with Gut Dysbiosis: Natural Therapeutic Use of Pre- and Probiotics
7. Overview of Nondigestible Oligo- and Polysaccharides (Dietary Fiber): Prebiotics
8. Prebiotic Fructans
9. Dysbiosis of the Microbiota: Therapeutic Strategies Utilizing Dietary Modification, Pro- and Prebiotics and Fecal Microbial Transplant Therapies in Promoting Normal Balance and Local Gi Functions
10. Oral Dysbiosis and Periodontal Disease: Impaired Systemic Physiology and Metabolic Diseases, Effects of Various Therapeutic Strategies
11. Intestinal Dysbiosis in Obesity, Metabolic Syndrome and Related Metabolic Diseases: Therapeutic Strategies Utilizing Pro- and Prebiotics
12. Gut Microbiota in Brain Development and Disorders of the CNS: Therapeutic Strategies Involving Dietary Modification and Pro- and Prebiotic Intervention
13. The Gut-Brain-Skin Axis and Role of Intestinal Dysbiosis in Acne Vulgaris: Therapeutic Effects of Pro- and Prebiotic Use
14. Microbiota: Role of Dysbiosis in Urogential Infections


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© Academic Press 2018
Academic Press
Paperback ISBN:

About the Author

Bryan Tungland

Dr. Tungland is a bacteriologist/microbiologist and chemist with more than 35 years of experience in food and food ingredient research and development. He specializes in effects of dietary modification and pr0 and prebiotic use in maintaining human health. He has authored or co-authored over 50 articles in peer- and non-peer reviewed journals and trades, and contributed 6 peer-reviewed book chapters on many scientific topics. He holds several patents in areas of food ingredient and process technology application, such as reducing sugar in frozen desserts, production of bioplastics and agrochemical time-release delivery, and technology associated with reducing blood glucose response in flour-containing processed foods. He is the sole proprietor in food and health and wellness consulting company, Tungland and Associates, LLC.

Affiliations and Expertise

President, CEO Tungland and Associates, LLC

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