Human Hypothalamus: Basic and Clinical Aspects, Part II

Human Hypothalamus: Basic and Clinical Aspects, Part II

1st Edition - December 30, 2003

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  • Author: Dick. F. Swaab
  • Hardcover ISBN: 9780444514905

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This volume provides a comprehensive understanding of the human hypothalamus, an extremely complex structure that consists of a large number of very different functional units. It approaches the subject in a way that has not historically existed in standard neuropathological investigations of the human brain. As the hypothalamus was traditionally considered to be a neuroendocrine structure, and hence of little interest to neurologists, this volume explores new findings in the field and the value they bring to the field of neurology. New understandings of the role the hypothalamus plays in memory and attention deficits in the dementias, along with greater evidence that the hypothalamus is related to symptoms and signs in both neurological and psychological disorders provide users in the fields of neuroscience, endocrinology, pediatrics, and psychology with a comprehensive resource on which to base new research and exploration.

Key Features

* A new understanding of the role of the human hypothalamus in neurological disorders
* Clinical evidence regarding a plethora of neurological disorders and how they relate to the human hypothalamus
* A greater understanding of the direct connection between both neurological and psychological disorders and the role of the hypothalamus in these disorders


Clinical neurologists and researchers in the neurosciences

Table of Contents

  • Part II. Neuropathology of the Human Hypothalamus and Adjacent Brain Structures.

    17. Vascular supply and vascular disorders. 17.1 Blood supply to the hypothalamus and pituitary. 17.2 Vascular lesions of the hypothalamus. 17.3. Choroid plexus of the third ventricle. 18. Disorders of development and growth. 18.1 Anencephaly. 18.2 Transsphenoidal encephalocele and empty sella syndrome. 18.3 Congenital midline defects: optic nerve hypoplasia and septo-optic dysplasia (De Morsier's syndrome). 18.4 Dystopia of the neurohypophysis. 18.5 The optic chiasm. 18.6 The growth hormone axis in development and aging. 18.7 Hydrocephalus. 18.8 Septum pellucidum abnormalities. 19. Tumors. 19.1 Symptoms due to hypothalamic tumors. 19.2 Germinoma and teratoma. 19.3 Hamartoma. 19.4 Glioma. 19.5 Craniopharyngioma, Rathke's cleft cysts and xanthogranuloma. 19.6 Dermoid and epidermoid tumors. 19.7 Pineal region tumors. 19.8 Tuberous sclerosis (Bourneville-Pringle syndrome) and tumors of the hypothalamus. 19.9 Metastases. 19.10 Other tumors. 20. Hypothalamic infections. 20.1 Inflammatory conditions affecting the hypothalamus. 20.2 Encephalitis lethargica (Von Economo's encephalitis). 20.3 Acquired immunodeficiency syndrome (AIDS). 21. Neuroimmunological disorders. 21.1 Neurosarcoidosis of the hypothalamus. 21.2 Multiple sclerosis (MS) and the hypothalamus. 21.3 Langerhans' cell histiocytosis (Hand-Schüller-Christian disease; histiocytosis-X).
    21.4 Other neuroimmunological hypothalamic disorders and lesions. 22. Drinking disorders. 22.1 Pathology of the neurohypophysis. 22.2 Diabetes insipidus. 22.3 Primary polydipsia and adipsia. 22.4 Nocturnal diuresis. 22.5 Vasopressin hypersecretion in diabetes mellitus. 22.6 Inappropriate secretion of vasopressin. 22.7 Wolfram's syndrome. 23. Eating disorders. 23.1 Prader-Willi syndrome. 23.2 Anorexia nervosa and bulimia nervosa. 23.3 Other eating disorders. 24. Reproduction, olfaction and sexual behavior. 24.1 Disorders of gonadotropic hormone regulation. 24.2 Olfaction, anosmia, the vomeronasal organ (Jacobson's organ) and the embryology of LHRH neurons. 24.3 Kallmann's syndrome. 24.4 Klinefelter's syndrome or testicular dysgenesis. 24.5 Sexual differentiation of the brain and sexual behavior. 25. Hypothalamic lesions following trauma and iatrogenic disorders. 25.1 Head/brain injury. 25.2 Neuroleptic malignant syndrome. 25.3 Hypothalamic injury by radiation. 25.4 Lesion of the pituitary stalk. 26. Hypothalamic involvement in psychiatric disorders. 26.1 Psychiatric symptoms due to tumors of the third ventricle. 26.2 Attacks of laughter (gelastic epilepsy). 26.3 Ventromedial hypothalamus syndrome and the effect of lesions on aggression. 26.4 Depression and mania. 26.5 The hypothalamus in mental deficiency. 26.6 Obsessive-compulsive disorder. 26.7 Anxiety disorders. 26.8 Fatigue syndromes. 26.9 Aggressive behavior. 27. Schizophrenia and autism. 27.1 Schizophrenia. 27.2 Autism. 28. Periodic disorders. 28.1 Kleine-Levin syndrome (periodic somnolence and morbid hunger). 28.2 Spontaneous periodic fever, hypothermia, Shapiro syndrome and periodic Cushing's syndrome. 28.3 Acute intermittent porphyria. 28.4 Narcolepsy. 28.5 Epileptic seizures. 29. Neurodegenerative disorders. 29.1 Alzheimer's disease and the hypothalamus. 29.2 Dementia with argyrophilic grains. 29.3 Parkinson's disease. 29.4 Huntington's disease. 29.5 Wernicke's encephalopathy, Korsakoff's psychosis and Marchiafava-Bignami disease. 29.6 Adrenomyeloneuropathy, adrenoleukodystrophy and hypothalamic-pituitary dysfunction. 29.7 Other neurodegenerative disorders. 30. Autonomic disorders. 30.1 Temperature regulation. 30.2 Disturbed thermoregulation. 30.3 Cardiovascular regulation. 30.4 Cardiovascular disturbances. 30.5 Circumventricular organs: lamina terminalis, subfornical organ and autonomic regulation. 30.6 Micturition. 30.7 Sleep. 31. Pain and addiction. 31.1 Opioid peptides and other addictive compounds. 31.2 Pain and the hypothalamus. 31.3 Headache. 32. Miscellaneous hypothalamic syndromes. 32.1 Idiopathic hypothalamic syndrome of childhood, a paraneoplastic syndrome. 32.2 Hypothalamic atrophy, Leigh's disease and Cornelia de Lange's syndrome. 32.3 Diencephalic idiopathic gliosis. 32.4 Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome. 32.5 Agenesis of the diencephalon. 32.6 Tourette's syndrome. 33. Brain death and 'dead' neurons. References. Subject Index for Part I and Part II.

Product details

  • No. of pages: 616
  • Language: English
  • Copyright: © Elsevier 2003
  • Published: December 30, 2003
  • Imprint: Elsevier
  • Hardcover ISBN: 9780444514905

About the Author

Dick. F. Swaab

Dick Swaab (1944) earned his medical and doctoral degrees at the University of Amsterdam, where he became involved in brain research during his third year of medical school. He was Director of the Netherlands Institute for Brain Research from 1978 to 2005. Since 1979 he is Professor of Neurobiology at the Medical Faculty, University of Amsterdam.

In 1985, Dr. Swaab founded the Netherlands Brain Bank (NBB) to serve as a source of clinically and neuropathologically well-documented research tissue. Since its founding, the Brain Bank has provided samples from more than 4,000 autopsies to 500 research groups in 25 countries. He was director of the NBB until 2005.

He is Leader Research team Neuropsychiatric Disorders, Neth. Inst for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences (KNAW). Swaab is also appointed for 2011-2017 Chao Kuang Piu Chair of Zhejiang University, Hangzhou, P.R. China.

His major research interests focus on, sexual differentiation of the human brain in relation to gender identity and sexual orientation, aging of the brain, Alzheimer’s disease, the neurobiological basis of depression, suicide and eating disorders. He has published over 540 papers in SCI journals, authored more than 200 chapters in books, and edited more than 60 books. Swaab mentored 84 PhD students from which 16 are now full professor. He is “Companion in the Order of the Dutch Lion”, bestowed by her Royal Majesty Queen Beatrix of the Netherlands. In 2008 Swaab obtained the Academy medal for his role in national and international neuroscience.

Dick Swaab is author of the 2 volume monograph The Human Hypothalamus that appeared in the Handbook of Clinical Neurology series, Elsevier, Amsterdam (1000 pp) and the Dutch best seller We are our Brains (450.000 copies sold), that is translated in 14 languages. A children's version of the book (You are your brains) has also appeared in Dutch in 2013 and Russian (2014). Swaab's H-factor is 76.

Affiliations and Expertise

Netherlands Institute for Brain Research, University of Amsterdam, Amsterdam, The Netherlands

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