Human Gonadotropins

Human Gonadotropins

1st Edition - July 1, 2022

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  • Authors: Laurence Cole, Stephen Butler
  • Paperback ISBN: 9780128216767

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Description

Human Gonadotropins is a must-have reference for basic science researchers looking to maximize their knowledge in this specific field of study. Luteinizing hormone, follicle-stimulating hormone, and human chorionic gonadotropin are essential for reproduction and outlined in detail in this work, covering topics ranging from antibodies and immunoassays, to commercial products and standards, genetics, and receptors and intermediaries for gonadotropins. Dr. Laurence Cole has been recognized for his outstanding research throughout his illustrious career. He has received awards from the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research. This detailed resource compiles all the recent research together into one volume, with one consistent voice.

Key Features

  • Covers the evolution, structure, synthesis, and functions of gonadotropins in meticulous detail
  • Includes sections on Degradation, Antibodies and Immunoassays, Commercial Products and Standards, and Receptors and Intermediaries
  • Details a section on Reproduction and Cancer, covering gestational trophoblastic diseases, ovarian cystic disorders, and hCG and cancer

Readership

Biomedical scientists and graduate students dealing with any of the human gonadotropins

Table of Contents

  • A. Evolution
    1. Evolution of Aa, GAH, FSH and LH
    2. Evolution of CG and Development of Humans

    B. Structure of the Gonadotropins
    3. Structure FSH Peptide/arbohydrate/3D Construction
    4. Structure LH Peptide/Carbohydrate/3D Construction
    5. Structure hCG Peptide/Carbohydrate/3D Construction
    6. Multiple forms of hCG Peptide/Carbohydrate/3D Construction

    C. Synthesis of the Gonadotropins
    7. Synthesis of the Gonadotropins

    D. Functions of the Gonadotropins
    8. Functions of Gonadotropin Releasing Hormone and Inhibin
    9. Function of FSH
    10. Function of LH
    11. Function of Hormone hCG
    12. Function of Hyperglycosylated hCG and Extravillous Cytotrophoblast hCG

    E. Degradation of the Gonadotropins
    13. Degradation hCG

    F. Antibodies and Immunoassays for the Gonadotropins
    14. Antibodies and Immunoassays for hCG

    G. Commercial products and standards for Gonadotropins
    15. Commercial Products and Standards for FSH
    16. Commercial Products and Standards for LH
    17. Commercial Products and Standards for hCG

    H. The Genetics of Gonadotropins
    18. The genetics of FSH
    19. The genetics of hCG and LH

    I. Sex Steroid Hormones
    20. Estrogens and Progestogens
    21. Male Steroidogenesis

    J. Female Reproduction
    22. Female reproduction: Follicle Formation and Follicle Selection
    23. Female reproduction: Ovulation and Luteinization
    24. Fertilization and Blastocyst Formation
    25. Illicit use of hCG in Dietary Programs and to Promote Anabolism

    K. Male Reproduction
    26. Male Reproduction: sperm formation
    27. Sperm Activation

    L. Adrenarche and Menarche
    28. Adrenarche and Menarche in Girls
    29. Adrenarche and Puberty in Boys

    M. Menstrual Cycle hCG
    30. Pituitary Sulfated hCG
    31. Hyperglycosylated hCG and Extravillous Cytotrophoblast hCG

    N. Pregnancy
    32. hCG and Pregnancy Tests
    33. False-positive hCG Pregnancy Tests
    34. hCG and Pregnancy
    35. Implantation and Pregnancy Failure
    36. Deep Implantation, hCG and Gestational Hypertension, Preeclampsia

    O. Roles of Gonadotropins in Reproduction and Cancer
    37. hCG and Gestational Trophoblastic Diseases
    38. The Human Brain: Sexuality
    39. Ovarian Cystic Disorders
    40. hCG and Choriocarcinoma
    41. hCG and Cancer

    P. Receptors and intermediaries for Gonadotropins
    42. Hyperglycosylated hCG, Extravillous Cytotrophoblast hCG and TGFß Receptor 2
    43. Receptor and Intermediators for FSH
    44. Receptor and Intermediaries for LH and the Hormone hCG

Product details

  • No. of pages: 264
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: July 1, 2022
  • Imprint: Elsevier
  • Paperback ISBN: 9780128216767

About the Authors

Laurence Cole

Dr. Cole has served on the journal editorial board from 1994-2001 as the Editor of "Trophoblast Disease Update". He has written more than 100 articles on hCG structure, physiology and immunoassay and on clinical applications of hCG or hCG-related molecules. He has a 1.17 FWCI in the Medicine category of SciVal where he has published throughout the various disciplines and maintains an average of 12.6 citations per article from 2009-2014. He has experience with international, single, and institutional collaboration. Awards and recognition for Dr. Cole include the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research.

Affiliations and Expertise

Director, USA hCG Reference Service, Santa Fe, New Mexico, USA

Stephen Butler

Dr. Butler attained his PhD from the University of London and after a Post-Doctoral Fellowship at Yale University School of Medicine he became an Assistant Professor at the University of New Mexico with the USA hCG Reference Service. Steve returned to the UK and, following positions at Queen Mary University of London and London Metropolitan University he spent seven years at Middlesex University as Reader (Associate Professor) in Biomedical Diagnostics. Dr Butler has been a Director for medical diagnostics companies and and is now a consultant biomedical diagnostics expert with a particular interest in diagnostics and therapeutics relating to hCG in pregnancy and cancer. He has published over 80 peer reviewed scientific articles, reviews, letters, patents, abstracts and book chapters in the field of molecular diagnostics. He is a global opinion leader on the structure and function of human chorionic gonadotropin (hCG) and its role as a diagnostic marker in fertility, pregnancy and cancer.

Affiliations and Expertise

Medical Diagnostics and Biomedical Research Consultant at SAB Scientific Consultancy,Bedfordshire, UK

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