Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs.

The first edition described the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions.

The second edition will include coverage of the many new discoveries that have been made in the last five years: hCG analogues may be the actual driving signal of all human cancers. The editor estimates that 40% of the out of date material will be excluded and replaced with 40% of the exciting new findings. The book will also have a much clearer pregnancy and cancer focus.

Key Features

  • It provides comprehensive information on hCG from basic science to clinical medicine
  • The second edition will include coverage of the many new discoveries that have been made in the last five years
  • Updated material with new findings in the field


Researchers in reproductive medicine, oncology, and endocrinology

Table of Contents

  • List of Contributors
  • About the Editors
    • Laurence A. Cole, PhD
    • Stephen A. Butler, PhD
  • Preface
    • References
  • Abbreviations
  • List of Tables
  • List of Figures
  • Part A: Introduction
    • 1. The expanding world of hCG
      • References
    • 2. History and introduction to human chorionic gonadotropin, a group of five independent growth factors
      • 2.1 History
      • 2.2 The pregnancy test
      • 2.3 Introduction to hCG
      • References
  • Part B: Synthesis, Structure and Function
    • 3. The molecular genetics of hCG
      • 3.1 The LH/hCG gene cluster
      • 3.2 Control of hCG gene expression: hCGα
      • 3.3 Control of hCG gene expression: hCGβ
      • 3.4 Summary
      • References
    • 4. Structure, synthesis, and secretion of hCG and hyperglycosylated hCG
      • 4.1 Amino acid sequence of hCG
      • 4.2 Carbohydrate structure of hCG
      • 4.3 hCG primary structure
      • 4.4 hCG secondary structure
      • 4.5 hCG tertiary structure
      • 4.6 hCG quaternary structure
      • 4.7 Combination of hCG subunits
      • 4.8 Synthesis and secretion of hCG
      • References
    • 5. Three-dimensional structures of hCG and hyperglycosylated hCG
      • 5.1 X-ray crystallography
      • 5.2 Refining this model
      • References
    • 6. Structures of hCG free α-subunit and free β-subunit
      • 6.1 Free α-subunit
      • 6.2 Free β-subunit
      • References
    • 7. Glycobiology of hCG
      • 7.1 Characteristic features of the sugar chains of glycoproteins
      • 7.2 Biosynthetic pathways of sugar chains of glycoproteins to form characteristic features
      • 7.3 The hCG sugar chains from urine of pregnant women and placenta
      • 7.4 Characteristic featur


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© 2015
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