Volume 88. HOX Genes

Preface

Chapter 1 The Bithorax Complex of Drosophila

1. Pseudoallelism and the History of the BX-C

2. The Ed Lewis Model

3. Molecular Genetics of the BX-C

4. Initiation and Maintenance Phases in BX-C Regulation

5. Initiators, Maintenance Elements, and Segment-Specific Enhancers

6. Organization of the Cis-Regulatory Regions into Chromosomal Domains

7. Chromatin Boundaries Flank the Parasegment-Specific Domains

8. Boundaries Versus Insulators and Long-Distance Interactions

9. Mixing the Old and the New

10. Colinearity in the BX-C

Chapter 2 Evolution of the Hox Gene Complex from an Evolutionary Ground State

1. Introduction

2. The Lewis Model

3. The Developmental and Evolutionary Ground State

4. Mechanisms of Epistatic Hox-Hox Interactions

5. The Evolutionary Origin of the Hox Cluster

6. Duplication and Divergence as a General Evolutionary Principle

7. Conclusion

Acknowledgments

Chapter 3 Hox Specificity

1. An Introduction to the Problem

2. Too Many Binding Sites, Not Enough Specificity

3. How Specific Do Hox Proteins Need to be?

4. Hox Cofactors

5. What Do In Vivo Hox-Binding Sites Look Like?

6. Insights into Hox Specificity from Structural Studies

7. Activity Regulation of Hox Proteins: The Role of Hox Collaborators

8. Insights into Hoxasome Function from cis‐Regulatory Element Architecture

9. Conclusions

Acknowledgments

Chapter 8 Hox Genes and Segmentation of the Vertebrate Hindbrain

1. Introduction

2. Hindbrain Segmentation

3. Expression of Hox Genes in the Hindbrain

4. Hox Gene Regulatory Networks in Hindbrain Segmentation

Acknowledgments

Chapter 5 Hox Genes in Neural Patterning and Circuit Formatio