HOX Genes

HOX Genes

1st Edition - July 13, 2009

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  • Editor: Olivier Pourquie
  • eBook ISBN: 9780080923123
  • Hardcover ISBN: 9780123745293

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A subgroup of homeobox genes, which play an important role in the developmental processes of a variety of multicellular organisms, Hox genes have been shown to play a critical role in vertebrate pattern formation. Hox genes can be thought of as general purpose control genes—that is, they are similar in many organisms and direct the same processes in a variety of organisms, from mouse, to fly, to human.

Key Features

* Provides researchers an overview and synthesis of the latest research findings and contemporary thought in the area

* Inclusion of chapters that discuss the evolutionary development of a wide variety of organisms

* Gives researchers and clinicians insight into how defective Hox genes trigger developmental abnormalities in embryos


Researchers in cell, developmental, and molecular biology; genetics

Table of Contents

  • Preface

    Chapter 1 The Bithorax Complex of Drosophila

    1. Pseudoallelism and the History of the BX-C

    2. The Ed Lewis Model

    3. Molecular Genetics of the BX-C

    4. Initiation and Maintenance Phases in BX-C Regulation

    5. Initiators, Maintenance Elements, and Segment-Specific Enhancers

    6. Organization of the Cis-Regulatory Regions into Chromosomal Domains

    7. Chromatin Boundaries Flank the Parasegment-Specific Domains

    8. Boundaries Versus Insulators and Long-Distance Interactions

    9. Mixing the Old and the New

    10. Colinearity in the BX-C

    Chapter 2 Evolution of the Hox Gene Complex from an Evolutionary Ground State

    1. Introduction

    2. The Lewis Model

    3. The Developmental and Evolutionary Ground State

    4. Mechanisms of Epistatic Hox-Hox Interactions

    5. The Evolutionary Origin of the Hox Cluster

    6. Duplication and Divergence as a General Evolutionary Principle

    7. Conclusion


    Chapter 3 Hox Specificity

    1. An Introduction to the Problem

    2. Too Many Binding Sites, Not Enough Specificity

    3. How Specific Do Hox Proteins Need to be?

    4. Hox Cofactors

    5. What Do In Vivo Hox-Binding Sites Look Like?

    6. Insights into Hox Specificity from Structural Studies

    7. Activity Regulation of Hox Proteins: The Role of Hox Collaborators

    8. Insights into Hoxasome Function from cis‐Regulatory Element Architecture

    9. Conclusions


    Chapter 8 Hox Genes and Segmentation of the Vertebrate Hindbrain

    1. Introduction

    2. Hindbrain Segmentation

    3. Expression of Hox Genes in the Hindbrain

    4. Hox Gene Regulatory Networks in Hindbrain Segmentation


    Chapter 5 Hox Genes in Neural Patterning and Circuit Formation in the Mouse Hindbrain

    1. Introduction

    2. Basic Anatomical Background and Cellular Mechanisms of Hindbrain Development

    3. The Impact of Segmental Patterning on Sensory Nuclei Columnar Organization and Projection Patterns

    4. Rostrocaudal Profiles and Sequential Phases of Hox Gene Expression: From Progenitor Patterning to Postmitotic Neuron Connectivity

    5. Hox Gene Function: Lessons from Mouse Knockouts


    Chapter Six Hox Networks and the Origins of Motor Neuron Diversity

    1. Introduction

    2. Spinal Motor Neuron Diversity

    3. Hox Expression in Developing Motor Neurons

    4. Hox Proteins Determine Motor Neuron Columnar Identity and Connectivity

    5. Hox Transcriptional Networks and the Specification of Motor Pool Identities

    6. Restriction and Refinement of Hox Activities During Motor Neuron Differentiation

    7. Conclusions

    Chapter 7 Establishment of Hox Vertebral Identities in the Embryonic Spine Precursors

    1. Introduction

    2. Initial Hox Gene Activation in Paraxial Mesoderm Precursors in the Epiblast

    3. Molecular Control of Temporal Colinearity

    4. Converting Temporal into Spatial Colinearity

    5. Posterior Prevalence is Required for the Establishment of Spatial Colinearity

    6. Spatial Dissociation of Segmentation and Hox Gene Activation Programs

    7. Definitive Positioning of Hox Gene Boundaries in the Somites

    8. Positioning of Hox Gene Boundaries in the Forming Segments

    9. Conclusion: Determination of the Axial Fate of Vertebral Precursors


    Chapter 8 Hox, Cdx, and Anteroposterior Patterning in the Mouse Embryo

    1. The Hox and Cdx Gene Family

    2. Similarities and Differences in the Two Expression Phases of Hox and Cdx Genes in the Mouse Embryo

    3. Hox and Cdx Gene Expression and A-P Patterning

    4. Conclusion


    Chapter 9 Hox Genes and Vertebrate Axial Pattern

    1. Introduction

    2. Hox Genes and the Axial Skeleton

    3. Hox Function in Axial Patterning

    4. Conclusions - The Nature of the Mammalian "Hox Code"

Product details

  • No. of pages: 328
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: July 13, 2009
  • Imprint: Academic Press
  • eBook ISBN: 9780080923123
  • Hardcover ISBN: 9780123745293

About the Serial Volume Editor

Olivier Pourquie

Affiliations and Expertise

Stowers Institute for Medical Research, Kansas City, MO, USA

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