Hormones and Aging

Hormones and Aging

1st Edition - February 26, 2021

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  • Editor: Gerald Litwack
  • Hardcover ISBN: 9780323855488
  • eBook ISBN: 9780323855495

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Hormones and Aging, Volume 115 in the Vitamins and Hormones series, highlights advances in the field, with this new volume presenting timely topics, including hypothalamic aging and hormones, endocannabinoids and aging-inflammation, neuroplasticity, mood and pain, the impact of hormones and bone loss across the menopause transition, and much more.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Vitamins and Hormones series
  • Includes the latest information on Hormones and Aging


Undergraduates, graduates, academics and researchers in the field of vitamins and hormones

Table of Contents

  • Preface

    Gerald Litwack

    1. Aging and the hypothalamic-pituitary-thyroid axis

    Leonidas H. Duntas

    2. Hypothalamic aging and hormones

    Zi-Jian Cai

    3. Hypothalamic gene transfer of BDNF promotes healthy aging

    Lei Cao, Seemaab Ali and Nicholas J. Queen

    4. Melatonin and healthy aging

    Daniel P. Cardinali

    5. Luteinizing hormone and the aging brain

    Megan Mey, Sabina Bhatta and Gemma Casadesus

    6. Leptin regulation of hippocampal synaptic function in health and disease

    Kirsty Hamilton and Jenni Harvey

    7. Endocannabinoids and aging—Inflammation, neuroplasticity, mood and pain

    Yongsoon Park and Bruce A. Watkins

    8. Parathyroid hormone levels and aging: Effect on balance

    Lavanya Murthy and Gustavo Duque

    9. Insulin and aging

    Mirian Ayumi Kurauti, Gabriela Moreira Soares, Carine Marmentini, Gabriela Alves Bronczek, Renato Chaves Souto Branco and Antonio Carlos Boschero

    10. Sirtuins and the prevention of immunosenescence

    Denise Lasigliè

    11. Alterations in cyclic nucleotide signaling are implicated in healthy aging and age-related pathologies of the brain

    Nicole Gorny and Michy P. Kelly

    12. Aging and FGF23-klotho system

    Makoto Kuro-O

    13. Aging and sex hormones in males

    Maria Chiara Decaroli, Sara De Vincenti and Vincenzo Rochira

    14. Sexual dimorphism, aging and immunity

    Veena Taneja

    15. Hormones and bone loss across the menopause transition

    Arun S. Karlamangla, Albert Shieh and Gail A. Greendale

    16. Relaxin abrogates genomic remodeling of the aged heart

    Guillermo Romero and Guy Salama

    17. Role of FoxO transcription factors in aging-associated cardiovascular diseases

    Sneha Mishra, Venkatraman Ravi and Nagalingam Ravi Sundaresan

    18. Ghrelin and adipokines: An overview of their physiological role, antimicrobial activity and impact on cardiovascular conditions

    Luís Perpétuo, Pierre Marie Voisin, Francisco Amado, Christophe Hirtz and Rui Vitorino

    19. Sex hormones and cognition in aging

    Caroline Gurvich, Jessica Le, Natalie Thomas, Elizabeth H. X. Thomas and Jayashri Kulkarni

    20. Role of hormones in sarcopenia

    Priego T, Martín AI, González-Hedström D, Granado M, López-Calderón A and Daniel Cardalini

    21. Sources of lumbar back pain during aging and potential therapeutic targets

    T. Peter Li, Amit Jain and Xu Cao

    22. Leydig cell aging: Molecular mechanisms and treatments

    V. Papadopoulos and B. Zirkin

    23. Adiponectin/AdipoRs signaling as a key player in testicular aging and associated-metabolic disorders

    Mayank Choubey, Ashutosh Ranjan and Amitabh Krishna

Product details

  • No. of pages: 656
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: February 26, 2021
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323855488
  • eBook ISBN: 9780323855495

About the Editor

Gerald Litwack

Gerald Litwack
Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.

Affiliations and Expertise

Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine, USA; Toluca Lake, North Hollywood, California, USA

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