Homology Effects offers contributions from an international panel of researchers whose aim has been both to introduce newcomers to the field of homology effects, and to bring colleagues up to date. Topic coverage includes dosage compensation, X-inactivation, imprinting, paramutation, homology-dependent gene silencing, transvection, pairing-sensitive silencing, nuclear organization of chromosomes, DNA repair, quelling, RIP, RNAi and antisense biology, homology effects in ciliates, prion biology, and a discourse on the evolution of gene duplications.
Advances in Genetics presents an eclectic mix of articles of use to all human and molecular geneticists. They are written and edited by recognized leaders in the field and make this an essential series of books for anyone in the genetics field.
Homology, the examination of similarity due to shared common ancestry, encompasses a fascinating class of phenomena in mammals, plants, insects, ciliates, nematodes, fungi, and bacteria. Homology effects concern processes that recognize homology at the level of DNA and/or RNA, as well as at the level of protein. Their collective history begins at the turn of the century and includes some of the most puzzling and extraordinary observations in biology. The volume covers phenomena that have often been considered unusual, exceptional to the rule, and "out of the ordinary" and, therefore, not for general study. However, it is now becoming clear that taken together, these phenomena represent a class of regulatory mechanisms that are widespread, as well as exceptionally powerful.
Geneticists (both basic and clinical), evolutionary biologists, molecular biologists, cell biologists, developmental biologists, and biochemists.
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- © Academic Press 2002
- 20th March 2002
- Academic Press
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Harvard Medical School, Boston, Massachusetts, U.S.A.
The Geisel School of Medicine, Dartmouth, NH, USA
@from:PRAISE FOR THE SERIES @qu:"Outstanding both in variety and in the quality of its contributions." @source:NATURE @qu:"Can be highly recommended to geneticists, and biologists in general...will prove to be of high importance for the development of the science of genetics." @source:SCIENCE @qu:"The high standards of the Advances series of Academic Press are now almost taken for granted..." @source:SCIENCE PROGRESS