Although it is one of the most-widely studied viruses, many mysteries still remain about HIV. Covering the latest advances and challenges associated with clinical application of new antiviral drugs and vaccines, this revised edition is a companion to Murad:HIV-1: Molecular Biology and Pathogenesis, 2E. Leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus.

Key Features

* The latest developments in HIV-vaccine research * New concepts in the discovery and design of novel anti-HIV drugs


Graduate students, postdoctoral fellows, and senior researchers in virology and pharmacology, as well as clinicians and clinical fellows in infectious diseases

Table of Contents

HIV Therapeutics: Past, Present, and Future HIV Drug Resistance and Viral Fitness Inhibitors of HIV-1 Reverse Transcriptase HIV-I Protease: Maturation, Enzyme Specificity, and Drug Resistance HIV-I Integrase Inhibitors: Past, Present, and Future Selection of HIV Replication Inhibitors: Chemistry and Biology Maturation or assembly inhibitor compounds against HIV-1 HIV-I Gene Therapy: Promise for the Future Assessment of HIV Vaccine Development: Past, Present, and Future CTL immunity approaches for HIV-1 vaccines humoral immunity approaches for HIV-1 vaccines. HIV-I-Associated Central Nervous System Dysfunction Molecular Mechanisms of Human Immunodeficiency Virus Type I Mother-Infact Transmission Molecular Epidemiology of HIV-I: An Example of Asia Simian Immunodeficiency Virus Infection of Monkeys as a Model System for the Study of AIDS Pathogenesis, Treatment and Prevention Animal Models for AIDS Pathogenesis SCID-hu mouse models for studying HIV-AIDS and for drug testing.


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© 2008
Academic Press
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About the serial-volume-editor

Kuan-Teh Jeang

Affiliations and Expertise

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.