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History of Risk Assessment in Toxicology - 1st Edition - ISBN: 9780128095324, 9780128095430

History of Risk Assessment in Toxicology

1st Edition

Editor: Sol Bobst
eBook ISBN: 9780128095430
Paperback ISBN: 9780128095324
Imprint: Academic Press
Published Date: 20th September 2017
Page Count: 50
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Table of Contents

1. Prehistory of Risk Assessment, case studies in Hazard Identification, Exposure Characterization, and Risk Characterization
2. Risk Assessment in the 20th Century Part I: Early lessons in Food Safety
3. Risk Assessment in the 20th Century Part II: The History of OSHA: Early lessons in Chemical Safety
4. Risk Assessment in the 20th Century Part III: The U.S. Environmental Protection Agency: Early lessons: pollution and environmental disasters
5. Risk Assessment goes Global: Review of the spread of risk assessment practices in North America, Europe, and Asia
6. Risk Assessment in the 21st Century: New Technologies and techniques


History of Risk Assessment in Toxicology guides the reader through the historical narrative of the evolution of risk assessment thinking in human and environmental practices. Risk assessment concepts are used in many different professional practice areas. In the health and environmental practices of risk assessment, the critical issue is often what chemical concentration in air, water, food, or a solid substance is acceptable, or considered not to result in any adverse effect.

The book reviews examples from early scientific and health studies to showcase the foundations of risk assessment. The book also explores the development of risk assessment as practiced by major regulatory bodies such as the US Food and Drug Administration (FDA), the Occupational Safety & Health Administration (OSHA), and the US Environmental Protection Agency (EPA) to reveal how risk assessment has evolved in the 20th and 21st centuries.

Modern technology has created opportunities in silicon in vitro, computational modeling, omics, and big data techniques to assess the toxicity of chemicals, while traditional approaches to risk assessment are being challenged with new and innovative approaches. Finally, current issues being debated and tested in risk assessment are outlined with possible future avenues suggested.

Key Features

  • Presents the first dedicated history on the evolution of risk assessment in toxicology
  • Reviews the development of major US and EU regulatory bodies
  • Provides a context to current debates surrounding the future of risk assessment
  • Reviews examples from early scientific and health studies to showcase the foundations of risk assessment


Toxicologists, epidemiologists, risk assessors, and regulators and societal decision makers. Secondary markets include environmental health researchers and practitioners and the risk science community


No. of pages:
© Academic Press 2017
20th September 2017
Academic Press
eBook ISBN:
Paperback ISBN:

Ratings and Reviews

About the Editor

Sol Bobst

Dr. Sol Bobst, PhD, DABT has participated in several risk assessment reviews. He is a ten year member of the Society of Toxicology and the past president of the Ethical, Legal, and Social Issues specialty section. He graduated Magna Cum Laude, University Honors with a Bachelor’s Degree in Chemistry from Drake University in Des Moines, IA. His Doctoral degree is from the University of Texas Health Science Center at Houston, Texas, and he holds a board certification from the American Board of Toxicology.

Affiliations and Expertise

Sr Regulatory Compliance and Toxicology Advisor, ToxSci Advisors