Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques

Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques

Kidney, Lung, Heart, Intestine and Mesenteric Lymph Node

1st Edition - July 29, 2022

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  • Author: George Parker
  • eBook ISBN: 9780323913980
  • Hardcover ISBN: 9780323913935

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Description

Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques: Kidney, Lung, Heart, Intestine and Mesenteric Lymph Node provides a thoroughly illustrated review of the tissue damage and reparative changes associated with standardized irradiation doses in rhesus macaques. In addition to time-sequenced, routinely stained histologic sections, the book presents results of numerous histochemical, immunohistochemical and chromogenic in-situ stains that provide insights into the pathogenesis of radiation-associated tissue injury and repair. This book is compiled and written by a board-certified veterinary pathologist with more than 40 years of experience in the interpretation of experimentally induced tissue alterations in laboratory animals. This is an important resource for researchers in the field of animal science radiation injury, including radiation oncologists and individuals involved in disaster preparedness related to accidental or deliberate radiation exposure in large populations.

Key Features

  • Addresses the chronological sequence of tissue alterations following defined radiation doses in rhesus macaques
  • Provides photo-documentation of a broad range of histochemical and immunohistochemical stains that illustrate tissue damage and reparative changes following irradiation
  • Presents insights into the involvement of various signaling and effector molecules in the development of radiation-associated injury

Readership

Researchers in nonhuman primate radiation (animal science and animal oncology). Radiation oncologists seeking translatable research for humans

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Foreword
  • Preface
  • Overview of studies
  • Irradiation protocol
  • Animal cage-side observations
  • Medical management
  • Dexamethasone treatment, nonsedated respiratory rate
  • Euthanasia
  • Necropsy and histology procedures
  • Acknowledgments
  • Funding
  • Further reading
  • Chapter 1. Radiation-associated changes in the kidney of rhesus macaques
  • Abstract
  • Overview
  • Staining and figures list
  • Detailed microscopic observations
  • References
  • Chapter 2. Radiation-associated changes in the lung of rhesus macaques
  • Abstract
  • Overview
  • Staining and figures list
  • Detailed microscopic observations
  • References
  • Chapter 3. Radiation-associated changes in the heart of rhesus macaques
  • Abstract
  • Overview
  • Stains and related figures
  • Detailed microscopic observations
  • References
  • Chapter 4. Radiation-associated changes in the jejunum of rhesus macaques
  • Abstract
  • Overview
  • Staining and figures list
  • Detailed microscopic observations
  • Chapter 5. Radiation-associated changes in the colon of rhesus macaques
  • Abstract
  • Overview
  • Staining and figure lists
  • Detailed colon observations
  • Chapter 6. Radiation-associated changes in the mesenteric lymph node of rhesus macaques
  • Abstract
  • Overview
  • Staining and figures list
  • Detailed microscopic observations
  • Index

Product details

  • No. of pages: 292
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: July 29, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780323913980
  • Hardcover ISBN: 9780323913935

About the Author

George Parker

Dr. George Parker currently serves as Senior Scientific Director, Global Pathology, at Charles River Laboratories. He received the Doctor of Veterinary Medicine (DVM) degree from the Auburn University College of Veterinary Medicine, completed a veterinary pathology residency at the Armed Forces Institute of Pathology, and received a PhD degree in immunology from Rutgers University. He is a diplomate of the American College of Veterinary Pathologists as well as the American Board of Toxicology, and a Fellow of the International Academy of Toxicologic Pathology. He has more than 30 years of experience as a toxicologic pathologist and has served as study pathologist on several hundred drug and chemical safety studies. He has published numerous book chapters and peer-reviewed journal articles that have been focused primarily on toxicologic pathology.

Affiliations and Expertise

Senior Scientific Director, Global Pathology, Charles River Laboratories, Durham, NC, USA

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