Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques

Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques

Kidney, Lung, Heart, Intestine and Mesenteric Lymph Node

1st Edition - July 1, 2022

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  • Author: George Parker
  • Hardcover ISBN: 9780323913935

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Description

Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques: Kidney, Lung, Heart, Intestine and Mesenteric Lymph Node provides a thoroughly illustrated review of the tissue damage and reparative changes associated with standardized irradiation doses in rhesus macaques. In addition to time-sequenced, routinely stained histologic sections, the book presents results of numerous histochemical, immunohistochemical and chromogenic in-situ stains that provide insights into the pathogenesis of radiation-associated tissue injury and repair. This book is compiled and written by a board-certified veterinary pathologist with more than 40 years of experience in the interpretation of experimentally induced tissue alterations in laboratory animals. This is an important resource for researchers in the field of animal science radiation injury, including radiation oncologists and individuals involved in disaster preparedness related to accidental or deliberate radiation exposure in large populations.

Key Features

  • Addresses the chronological sequence of tissue alterations following defined radiation doses in rhesus macaques
  • Provides photo-documentation of a broad range of histochemical and immunohistochemical stains that illustrate tissue damage and reparative changes following irradiation
  • Presents insights into the involvement of various signaling and effector molecules in the development of radiation-associated injury

Readership

Researchers in nonhuman primate radiation (animal science and animal oncology). Radiation oncologists seeking translatable research for humans

Table of Contents

  • Chapter 1: Kidney 
    Routine histology stain-  
    Hematoxylin & eosin 
    Histochemical stains- 
    Periodic acid-Schiff/hematoxylin 
    Phosphotungstic acid/hematoxylin 
    Chromotrope-aniline blue  
    Masson’s trichrome 
    Immunohistochemical stains- 
    von Willebrand factor 
    Collagen 1 
    Alpha smooth muscle actin 
    Connective tissue growth factor 
    CD3 
    CD20 
    CD31 
    CD38 
    CD68 
    CD163 
    Myeloperoxidase 
    Tryptase 
    Galectin-3 
    Pro-renin receptor 

    Chapter 2: Lung 
    Routine histology stain-  
    Hematoxylin & eosin 
    Histochemical stains- 
    Masson’s trichrome 
    Toluidine blue 
    Immunohistochemical stains- 
    Collagen 1 
    Alpha smooth muscle actin 
    Connective tissue growth factor 
    CD31  
    CD163 
    CD206 
    Myeloperoxidase 
    Tryptase 
    Galectin-3 
    Transforming growth factor-beta 
    Caspase 3 

    Chapter 3: Heart 
    Routine histology stain-  
    Hematoxylin & eosin  
    Histochemical stains- 
    Masson’s trichrome 
    Immunohistochemical stains- 
    Caspase 3 
    Galectin-3 
    Alpha smooth muscle actin 

    Chapter 4: Jejunum 
    Routine histology stain-  
    Hematoxylin & eosin  
    Histochemical stains- 
    Masson’s trichrome 
    Alcian blue/periodic acid-Schiff 
    Immunohistochemical stains- 
    MxA 
    Ki67 
    Connective tissue growth factor 
    Collagen 1 
    CD13 
    CD163 
    Lipopolysaccharide 

    Chapter 5: Colon 
    Routine histology stain-  
    Hematoxylin & eosin  
    Histochemical stains- 
    Masson’s trichrome 
    Alcian blue/periodic acid-Schiff 
    Immunohistochemical stains 
    Ki67 
    Collagen 1 
    Connective tissue growth factor 
    CD163 
    Lipopolysaccharide 

    Chapter 6: Mesenteric lymph node 
    Routine histology stain-  
    Hematoxylin & eosin  
    Histochemical stains- 
    Masson’s trichrome  
    Immunohistochemical stains- 
    Collagen 1 
    Myeloperoxidase 
    MxA 
    Lipopolysaccharide 
    Transforming growth factor-beta 
    Tryptase 
    CD163 

Product details

  • No. of pages: 616
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: July 1, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323913935

About the Author

George Parker

Dr. George Parker currently serves as Senior Scientific Director, Global Pathology, at Charles River Laboratories. He received the Doctor of Veterinary Medicine (DVM) degree from the Auburn University College of Veterinary Medicine, completed a veterinary pathology residency at the Armed Forces Institute of Pathology, and received a PhD degree in immunology from Rutgers University. He is a diplomate of the American College of Veterinary Pathologists as well as the American Board of Toxicology, and a Fellow of the International Academy of Toxicologic Pathology. He has more than 30 years of experience as a toxicologic pathologist and has served as study pathologist on several hundred drug and chemical safety studies. He has published numerous book chapters and peer-reviewed journal articles that have been focused primarily on toxicologic pathology.

Affiliations and Expertise

Senior Scientific Director, Global Pathology, Charles River Laboratories, Durham, NC, USA

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