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Hematopoiesis
1st Edition, Volume 118 - April 27, 2016
Editor: Emery Bresnick
Language: English
Hardback ISBN:9780128033197
9 7 8 - 0 - 1 2 - 8 0 3 3 1 9 - 7
eBook ISBN:9780128033265
9 7 8 - 0 - 1 2 - 8 0 3 3 2 6 - 5
Hematopoiesis, the latest volume in the Current Topics in Developmental Biology, covers hematopoiesis, with contributions from an international board of authors. Its chapters pro…Read more
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Hematopoiesis, the latest volume in the Current Topics in Developmental Biology, covers hematopoiesis, with contributions from an international board of authors. Its chapters provide a comprehensive set of reviews covering such topics as the regulation of blood stem cell development, epigenetic mechanisms controlling erythropoiesis, and regulatory RNAs/HSCs.
Covers the area of hematopoiesis
International board of authors
Provides a comprehensive set of reviews covering such topics as regulation of blood stem cell development, epigenetic mechanisms controlling erythropoiesis, and regulatory RNAs/HSCs
Researchers in cell, developmental and molecular biology and in genetics.
Preface
Chapter One: Regulation of Blood Stem Cell Development
Abstract
1 Introduction
Chapter Two: Hematopoietic Stem Cell and Its Bone Marrow Niche
Abstract
1 Introduction
2 Evolution of the Stem Cell Niche Concept
3 Location Matters
4 Cellular Participants in the Bone Marrow Microenvironment
5 The Sympathetic Nervous System
6 HSC Mobilization from the BM Niche
7 Niche of Hematopoietic Malignancies
8 Perspectives
Chapter Three: The Hematopoietic Stem and Progenitor Cell Cistrome: GATA Factor-Dependent cis-Regulatory Mechanisms
Abstract
1 cis-Regulatory Mechanisms
2 GATA Factor Interactions with DNA and Chromatin
3 Components of Scl/TAL1 and GATA Factor Complexes at E-box–GATA Elements
4 HSPC Cistrome
5 Perspective
Chapter Four: ETS Transcription Factor ETV2/ER71/Etsrp in Hematopoietic and Vascular Development
Abstract
1 Introduction
2 Etv2 Is Transiently Expressed in the Hemangiogenic Progenitors
3 ETV2 Is Sufficient to Induce Hematopoietic and Endothelial Cell Formation
4 Nonredundant and Transient Role of ETV2 in Hematopoietic and Endothelial Cell Formation
5 ETV2, VEGF, and FLK1 in Hematopoietic and Endothelial Cell Formation
6 ETV2 Regulates Hemangiogenic versus Cardiac Mesoderm Outcome
7 ETS Hierarchy and ETS Switching Mechanisms in Hematopoietic and Vascular Development
8 ETV2 in Definitive Hematopoietic Program and Function
9 Regulation of Etv2 Expression
10 Closing Thoughts and Future Directions
Acknowledgments
Chapter Five: Taking the Leap: Runx1 in the Formation of Blood from Endothelium
Abstract
1 The Three Waves of Blood Cell Formation
2 The Role of Runx1 in the Formation of Embryonic Progenitors and HSCs
3 The Temporal Requirement for Runx1 in Hemogenic Endothelium
4 Downstream Runx1 Targets That Execute the Endothelial to Hematopoietic Cell Transition