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Heat Transfer and Fluid Flow in Biological Processes - 1st Edition - ISBN: 9780124080775, 9780124079007

Heat Transfer and Fluid Flow in Biological Processes

1st Edition

Editors: Sid Becker Andrey Kuznetsov
Hardcover ISBN: 9780124080775
eBook ISBN: 9780124079007
Imprint: Academic Press
Published Date: 31st December 2014
Page Count: 428
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Heat Transfer and Fluid Flow in Biological Processes covers emerging areas in fluid flow and heat transfer relevant to biosystems and medical technology. This book uses an interdisciplinary approach to provide a comprehensive prospective on biofluid mechanics and heat transfer advances and includes reviews of the most recent methods in modeling of flows in biological media, such as CFD. Written by internationally recognized researchers in the field, each chapter provides a strong introductory section that is useful to both readers currently in the field and readers interested in learning more about these areas.

Heat Transfer and Fluid Flow in Biological Processes is an indispensable reference for professors, graduate students, professionals, and clinical researchers in the fields of biology, biomedical engineering, chemistry and medicine working on applications of fluid flow, heat transfer, and transport phenomena in biomedical technology.

Key Features

  • Provides a wide range of biological and clinical applications of fluid flow and heat transfer in biomedical technology
  • Covers topics such as electrokinetic transport, electroporation of cells and tissue dialysis, inert solute transport (insulin), thermal ablation of cancerous tissue, respiratory therapies, and associated medical technologies
  • Reviews the most recent advances in modeling techniques


Graduate students, professors, and clinical researchers and professionals whose work relates to fluid flow, heat transfer, and mass transport across the biological, biomedical sciences, and engineering fields.

Table of Contents

Chapter 1: Bioheat Transfer and Thermal Heating for Tumor Treatment

  • Abstract
  • 1.1 Pennes’ and Other Bioheat Transfer Equations
  • 1.2 Blood Flow Impacts on Thermal Lesions with Pulsation and Different Velocity Profiles
  • 1.3 Thermal Relaxation Time Factor in Blood Flow During Thermal Therapy
  • 1.4 PBHTE with the Vascular Cooling Network Model
  • 1.5 Hyperthermia Treatment Planning

Chapter 2: Tissue Response to Short Pulse Laser Irradiation

  • Abstract
  • 2.1 Introduction
  • 2.2 Mathematical Formulation
  • 2.3 Experimental Methods
  • 2.4 Results and Discussion
  • 2.5 Conclusion

Chapter 3: Quantitative Models of Thermal Damage to Cells and Tissues

  • Abstract
  • 3.1 Introduction
  • 3.2 Heat Transfer in Tissue
  • 3.3 Reaction Rates and Temperature
  • 3.4 Thermal Denaturation of Proteins
  • 3.5 Cells
  • 3.6 Tissue-Level Descriptions
  • 3.7 Discussion

Chapter 4: Analytical Bioheat Transfer: Solution Development of the Pennes’ Model

  • Abstract
  • 4.1 Pennes’ Bioheat Equation in Living Tissue Analogy
  • 4.2 Solutions to the Transient Homogenous Bioheat Equation
  • 4.3 Solution Approaches to Nonhomogenous Problems
  • 4.4 Additional Considerations
  • 4.5 The Composite Bioheat Problem
  • 4.6 Summary Remarks

Chapter 5: Characterizing Respiratory Airflow and Aerosol Condensational Growth in Children and Adults Using an Imaging-CFD Approach

  • Abstract
  • 5.1 Introduction
  • 5.2 Methods
  • 5.3 Results
  • 5.4 Discussion
  • 5.5 Conclusion

Chapter 6: Transport in the Microbiome

  • Abstract
  • 6.1 Introduction
  • 6.2 The Human Microbiome
  • 6.3 Swimming Microorganisms
  • 6.4 Continuum Descriptions
  • 6.5 Discussion

Chapter 7: A Critical Review of Experimental and Modeling Research on the Leftward Flow Leading to Left-Right Symmetry Breaking in the Embryonic Node

  • Abstract
  • Acknowledgments
  • 7.1 Introduction
  • 7.2 Experimental Research on the Leftward Nodal Flow and LR Symmetry Breaking
  • 7.3 Modeling Research on the Nodal Flow
  • 7.4 Leftward Flow or Flow Recirculation?
  • 7.5 Sensing of the Flow: Mechanosensing or Chemosensing?
  • 7.6 Modeling the Effect of a Ciliated Surface by Imposing a Given Vorticity at the Edge of the Ciliated Layer
  • 7.7 Summary of Relevant Parameters Describing the Nodal Flow and Estimates of Their Values
  • 7.8 Numerical Results Obtained Assuming a Constant Vorticity at the Edge of the Ciliated Layer
  • 7.9 Conclusions

Chapter 8: Fluid-Biofilm Interactions in Porous Media

  • Abstract
  • 8.1 Microbial Biofilms in Porous Media
  • 8.2 A Motivating Problem: Biofilms and the Fate of Contaminants in Soil
  • 8.3 Models of Biofilm Growth and Pattern Formation in Quiescent Fluids
  • 8.4 Computational Simulation of Fluid-Biofilm Interactions in Porous Media
  • 8.5 Mechanisms of Biological Clogging in Porous Media
  • 8.6 Summary

Chapter 9: Flow Through a Permeable Tube

  • Abstract
  • 9.1 Introduction
  • 9.2 Axisymmetric Stokes Flow
  • 9.3 Flow Through an Infinite Permeable Tube
  • 9.4 Starling’s Equation
  • 9.5 Flow Through a Tube with Finite Length
  • 9.6 Effect of Wall Slip
  • 9.7 Summary

Chapter 10: Transdermal Drug Delivery and Percutaneous Absorption: Mathematical Modeling Perspectives

  • Abstract
  • 10.1 Introduction
  • 10.2 Physiological Description and Drug Transport Models
  • 10.3 Review of Mathematical Methods
  • 10.4 Modeling TDD Through a Two-Layered System
  • 10.5 Conclusions

Chapter 11: Mechanical Stress Induced Blood Trauma

  • Abstract
  • 11.1 Introduction
  • 11.2 Mechanical Stresses Experienced by Blood
  • 11.3 Fluid Dynamic Effects on Blood Constituents
  • 11.4 Numerical Models of Damage to the Blood Constituents
  • 11.5 Summary

Chapter 12: Modeling of Blood Flow in Stented Coronary Arteries

  • Abstract
  • Acknowledgments
  • 12.1 Introduction
  • 12.2 Hemodynamic Quantities of Interest
  • 12.3 Fluid Dynamic Models of Idealized Stented Geometries
  • 12.4 Fluid Dynamic Models of Image-Based Stented Geometries
  • 12.5 Limitations of the Current CFD Models and Future Remarks
  • 12.6 Conclusions

Chapter 13: Hemodynamics in the Developing Cardiovascular System

  • Abstract
  • 13.1 Introduction
  • 13.2 The Chicken Embryo Model System
  • 13.3 Relevant Fluid Mechanic Regimes
  • 13.4 Experimental Studies
  • 13.5 Mechanotransduction
  • 13.6 Hemorheology
  • 13.7 Conclusions and Outlook


No. of pages:
© Academic Press 2015
31st December 2014
Academic Press
Hardcover ISBN:
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About the Editors

Sid Becker

Sid Becker is an Associate Professor in the Department of Mechanical Engineering at the University of Canterbury. He is an Alexander von Humboldt Fellow and is a recipient of the Royal Society of New Zealand Marsden Grant. He has held academic positions in Germany, the United States, and New Zealand. His research is primarily in computational and analytical modelling of heat and mass transfer processes in biological media. Dr. Becker is also the editor of the book Modeling of Microscale Transport in Biological Processes (2017) and co-editor of the books Heat Transfer and Fluid Flow in Biological Processes (2015), and Transport in Biological Media (2013).

Affiliations and Expertise

Associate Professor in the Department of Mechanical Engineering at the University of Canterbury

Andrey Kuznetsov

Andrey Kuznetsov

Dr. Kuznetsov is Professor at the Department of Mechanical & Aerospace Engineering at North Carolina State University. He holds a joint professorial position at the University of North Carolina’s Biomedical Engineering Department. He is a Fellow of American Society of Mechanical Engineering, an Editorial Board Member of the Proceeding of the Royal Society A, and an Associate Editor of the Journal of Porous Media. He is a recipient of the prestigious Humboldt Research Award. In 2014, Dr. Kuznetsov was elected as a Member of the Scientific Council of the International Center of Heat and Mass Transfer. He has published more than 400 journal papers, 17 book chapters, 3 books, and 100 conference papers. His works have been cited over 12,000 times: he has an h-index of 51 and an i-10 index of over 220. While his most notable early contributions are in the development of the field of porous media, Prof. Kuznetsov’s research interests in the general area of numerical modeling are extensive, including transport in living tissues, sub-cellular transport, mass transport in neurons and axons, bioheat transport, bioconvective sedimentation, fluid mechanics, flows in microgravity, and turbulence.

Affiliations and Expertise

Professor at the Department of Mechanical & Aerospace Engineering at North Carolina State University

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