Volume 4A: List of Contributors. Preface (R.A. Haworth and R.A. Altschuld). Part I Contractile Function. Structural and Functional Properties of the Hypertrophied and Failing Heart (R. Jacob, R.W. Gulch, and G. Kissling). The Role of Myocardial Force-Frequency Relation in left Ventricular Function and Progression of Human Heart Failure (L.A. Mulieri and N.R. Alpert). Calcium Homeostasis in Human Heart Failure (U. Schmidt, R.J. Hajjar, M. Carles, and J.K. Gwathmey). Adrenergic Regulation (S.E. Harding and A.R.W. Money-Kyrle). Part II Energy Supply. Energetics of the Normal and Failing Human Heart: Focus on the Creatine Kinase Reaction (J.S. Ingwall). ATP and Cytochrome C Oxidase in the Failing Human Heart (R.C. Starling, R. Liebes, D. Medeiros, and R.A. Altschuld). Phosphorylation Potential and Free Energy of ATP (H. Kammermeier). Altered Oxygen Availability and the Role of Nitric Oxide in the Development of Heart Failure (S.K. Laycock, X. Zhang, N. Seyedi, G. Zhao, R.D. Bernstein, and T.H. Hintze). Volume 4B: List of Contributors. Preface (R.A. Haworth and R.A. Altschuld). Metabolic and Mitochondrial Chages in the Failure Condition of Myocardial Hibernation: Present Understanding, Existing Controversies, and FUture Genetic Approaches (A.J. Liedtke). Part III Energy Demand. Human Heart Failure: Excitation-Contaction Coupling ECC (N.R. Alpert and L.A. Mulieri). Myocardial Oxygen Consumption in Heart Failure (M.R. Wolff). Part IV Etiology of Failure. Cardiovascular Aging in Health (M. Boluyt and E.G. Lakatta). Pathophosiology of the Renin-Angiotensin System in Heart Failure: Molecular Control through Encocrine, Paracrine, and Autocrine Pathways (D.E. Dostal and K.M. Baker). The Molecular Basis of Cardiomyopathies due to Genetic Deficiencies of Mitochondrial Proteins (A.W. Strauss and D.P. Kelly). Part V Therapeutics. Treatment of Heart Failure (C.V. Leier). Index.