Heart Failure with Preserved Ejection Fraction, An Issue of Heart Failure Clinics

1st Edition, Volume 17-3 - June 4, 2021
Editors: Geu-Ru Hong, Mani Vannan
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 3 5 3 8 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 3 5 3 9 - 8

This issue of Heart Failure Clinics, guest edited by Geu-Ru Hong, will cover key topics in Heart Failure with Preserved Ejection Fraction. This issue is one of four selected each… Read more

Heart Failure with Preserved Ejection Fraction, An Issue of Heart Failure Clinics

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This issue of Heart Failure Clinics, guest edited by Geu-Ru Hong, will cover key topics in Heart Failure with Preserved Ejection Fraction. This issue is one of four selected each year by our series consulting editor, Dr. Eduardo Bossone. Topics discussed in this issue will include: Current Trends and Outcomes of Heart Failure with Preserved Ejection Fraction, Pathogenesis and Phenotypes of Heart Failure with Preserved Ejection Fraction,
Hypertension and Heart Failure with Preserved Ejection Fraction, Obesity in Heart Failure with Preserved Ejection Fraction, Noninvasive Hemodynamic Evaluation at rest in Heart Failure with Preserved Ejection Fraction, Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction and response to therapy, among others.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Current Prevalence, Incidence, and Outcomes of Heart Failure with Preserved Ejection Fraction
Key points
Introduction
Diagnosis
Prevalence
Incidence
Risk factors and comorbidities
Quality of life and hospitalization
Mortality
Further studies
Summary
Clinics care points
Disclosure
Pathophysiology of Heart Failure with Preserved Ejection Fraction
Key points
Introduction
Terminology: diastolic dysfunction versus diastolic HF versus heart failure with preserved ejection fraction
Pathophysiology: diastolic dysfunction versus nondiastolic abnormalities versus noncardiac abnormalities in heart failure with preserved ejection fraction
Diastolic dysfunction in heart failure with preserved ejection fraction
Cellular and molecular mechanisms of diastolic dysfunction
Nondiastolic cardiac abnormalities in heart failure with preserved ejection fraction
Noncardiac abnormalities in heart failure with preserved ejection fraction
Summary
Clinics care points
Hypertension and Heart Failure with Preserved Ejection Fraction
Key points
Introduction
Pathophysiological mechanisms linking hypertension and heart failure with preserved ejection fraction
Treatment of hypertension in heart failure with preserved ejection fraction
Clinics care points
Obesity and Heart Failure with Preserved Ejection Fraction
Key points
Heart failure with preserved ejection fraction phenotypes
The heart failure with preserved ejection fraction obesity phenotype
Pathophysiology of obese heart failure with preserved ejection fraction
Diagnosis of heart failure with preserved ejection fraction with obesity
Clinical outcomes of heart failure with preserved ejection fraction patients with obesity and the obesity paradox
Targeted treatment of the obese heart failure with preserved ejection fraction phenotype
Summary
Clinics care points
Renal Dysfunction and Heart Failure with Preserved Ejection Fraction
Key points
Introduction
Chronic kidney disease and worsening renal failure
Clinical features
The heart’s effect on the kidney
Chronotropic incompetence
Endothelium
Inflammation
Biomarkers in renal dysfunction and heart failure with preserved ejection fraction
Hemodynamic factors
Renal parameters in heart failure with preserved ejection fraction
Cardiac morphology in renal dysfunction and heart failure with preserved ejection fraction
Renin-angiotensin-aldosterone system inhibition and renal function in heart failure with preserved ejection fraction
Sodium glucose cotransporter-2 inhibitors
CONNECT and RECONNECXT
Summary
Clinics care points
Sleep Disorder and Heart Failure with Preserved Ejection Fraction
Key points
Introduction
Summary
Clinics care points
Disclosure
Atrial Fibrillation and Heart Failure with Preserved Ejection Fraction: Two Chronic Troublemakers
Key points
Introduction
Definitions of heart failure with preserved ejection fraction and atrial fibrillation
Mechanistic interaction between atrial fibrillation and heart failure with preserved ejection fraction
Diagnosis of heart failure with preserved ejection fraction in atrial fibrillation
Outcomes of heart failure with preserved ejection fraction in atrial fibrillation
Future perspectives
Summary
Clinics care points
Valvular Disease and Heart Failure with Preserved Ejection Fraction
Key points
Introduction
Primary heart failure with preserved ejection fraction and secondary valvular heart disease
Primary valvular heart disease and secondary heart failure with preserved ejection fraction
Summary
Clinics care points
Exercise Intolerance in Heart Failure with Preserved Ejection Fraction
Key points
Introduction
Exercise intolerance in heart failure with preserved ejection fraction
Effects of exercise training in heart failure with preserved ejection fraction
Exercise tolerance differences between heart failure with preserved ejection fraction and heart failure with reduced ejection fraction
Clinical implications and future perspectives
Summary
Disclosure
Clinics care points
Invasive Hemodynamics in Heart Failure with Preserved Ejection Fraction: Importance of Detecting Pulmonary Vascular Remodeling and Right Heart Function
Key points
Introduction
Hemodynamics using left heart catheterization
Role of atrial remodeling and failure
Right ventricular hemodynamics
Pulmonary artery compliance and pulmonary vascular resistance
Pulmonary vascular resistance and precapillary pulmonary vascular resistance in heart failure with preserved ejection fraction
Future directions
Summary
Clinics care points
Noninvasive Hemodynamic Evaluation at Rest in Heart Failure with Preserved Ejection Fraction
Key points
Introduction
Systolic pulmonary artery pressure and pulmonary hypertension
Prevalence of pulmonary hypertension in heart failure with preserved ejection fraction by echocardiography
Novel measures in pulmonary hypertension and heart failure with preserved ejection fraction
Central venous pressure
Right ventricle structure and function
Systolic left ventricle function and heart failure with preserved ejection fraction
Systolic function by Doppler echocardiography
Diastolic dysfunction
Tissue Doppler imaging and left atrial filling pressures
Diagnosis of diastolic dysfunction
Prevalence of diastolic dysfunction in heart failure with preserved ejection fraction
atrial strain in heart failure with preserved ejection fraction
Left heart cardiac chambers
Diagnostic algorithms of heart failure with preserved ejection fraction
Summary
Clinics care points
Stress Testing in Heart Failure with Preserved Ejection Fraction
Key points
Introduction
The rationale for stress testing to diagnose heart failure with preserved ejection fraction
Application of appropriate stress methods
Alternative methods to supine bicycle stress echocardiography
Stress testing for diagnosing heart failure with preserved ejection fraction in consensus recommendations
The protocol of diastolic stress echocardiography
Interpretation of main parameters from diastolic stress echocardiography
Summary
Clinics care points
Conflict of interest
Comprehensive Assessment of Heart Failure with Preserved Ejection Fraction Using Cardiac MRI
Key points
Introduction
Heart failure with preserved ejection fraction imaging
Novel methods and future directions
Summary
Clinics care points
Current Status of Pharmacologic and Nonpharmacologic Therapy in Heart Failure with Preserved Ejection Fraction
Key points
Introduction
Diverse pathophysiology of heart failure with preserved ejection fraction and its phenotype
Efforts to increase the accuracy of heart failure with preserved ejection fraction diagnosis
Pharmacologic and nonpharmacologic treatment
Summary
Clinics care points
Clinical Phenogroups in Heart Failure with Preserved Ejection Fraction
Key points
Introduction
Summary
Clinics care points
Sources of Funding
Phenomapping Heart Failure with Preserved Ejection Fraction Using Machine Learning Cluster Analysis: Prognostic and Therapeutic Implications
Key points
Introduction
Pathophysiology of heart failure with preserved ejection fraction
Phenomapping in heart failure with preserved ejection fraction
Phenogroups in heart failure with preserved ejection fraction
Pathophysiology and treatment across the proposed heart failure with preserved ejection fraction phenogroups
Summary
Clinics care points

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Geu-Ru Hong

Mani Vannan