Heart Development and Regeneration

1st Edition

Editors: Nadia Rosenthal Richard Harvey
Hardcover ISBN: 9780123813329
eBook ISBN: 9780123813336
Imprint: Academic Press
Published Date: 28th May 2010
Page Count: 1136
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The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry.

Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances.

Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases.

Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration.

Key Features

Authored by world experts in heart development and disease

New research on epigenetic modifiers in cardiac development

Comprehensive coverage of stem cells and prospects for cardiac regeneration

Up-to-date research on transcriptional and proteomic circuits in cardiac disease

Full-color, detailed illustrations


Clinicians, medical researchers, students, and professors.

Table of Contents

Volume 1

1.1 Evolutionary Origins of Hearts

1.2 Development and Aging of the Drosophila Heart

1.3 Cardiac Development in the Frog

1.4 Cardiac Development in the Zebrafish

1.5 An Overview of Avian Heart Structure and Development

2.1 The Specification of Myocardial Progenitor Cells in the Ciona Tadpole

2.2 The Secondary Heart Field

2.3 Patterning and Development of the Conduction system of the Heart

3.1 The Behaviour of Cells that Form the Myocardial Compartments of the Heart
3.2 The Ballooning Model for Formation of Cardiac Chambers

3.3 Retinoids and Heart Development

3.4 A System for Describing Congenital Cardiac Malformations and Correlating Them With Abnormal Cardiac Development

4.1 Cardiac Left-Right Asymmetry

4.2 Molecular Mechanisms of Left/Right Development

4.3 Pitx2 in Cardiac Left Right Asymmetry and Human Disease

5.1 Epicardial Lineage: Origins and Fates

5.2 The Epicardial Signaling Center in Development and Disease

6.1 Molecular Regulation of Cushion Morphogenesis

6.2 Signalling Pathways in Valve Formation: Origins of Congenital Defects

7.1 Role of Cardiac Neural Crest Cells in Morphogenesis of the Heart and Great Vessels

7.2 Role of Cardiac Neural Crest in the Development of the Caudal Pharyngeal Arches, the Cardiac Outflow and Disease

8.1 Origin of the Vertebrate Endothelial Cell Lineage: Ontogeny and Phylogeny

8.2 Vascular Development

8.3 Arterio-Venous Patterning in the Vascular System

8.4 Lymphatic Vascular Development

Volume 2

1.1 NK-2 Class Homeodomain Proteins: Conserved Regulators of Cardiogenesis

1.2 GATA4 in Heart Development and Disease

1.3 Serum Response Factor and Cofactors, Roles in Cardiac Development

1.4 T-box Factors

1.5 Myocyte Enhancer Factor 2 Transcription Factors in Heart Development and Di


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About the Editor

Nadia Rosenthal

Affiliations and Expertise

European Molecular Biology Laboratory, Monterotondo (Rome), Italy

Richard Harvey

Affiliations and Expertise

Victor Chang Cardiac Research Institute, Sydney, Australia